Entecavir Monohydrate CAS 209216-23-9 falegaosimea API Tulaga maualuga Fa'ama'i Hepatitis B.
Tuuina atu a le Faumea ma le Mamalu Maualuga ma le Tulaga Lelei
Igoa vaila'au: Entecavir Monohydrate
CAS: 209216-23-9
Fa'aaogaina ile togafitiga ole Fa'ama'i Hepatitis B
API Tulaga Maualuga, Gaosiga Fa'apisinisi
Igoa Vailaau | Entecavir Monohydrate |
Synonyms | Entecavir Hydrate;9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine Monohydrate |
Numera CAS | 209216-23-9 |
CAT Numera | RF-API79 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
Fuafua mole | C12H17N5O4 |
Molecular Weight | 295.3 |
Lisi Lisi | >220℃ |
Malosi | 1.81 |
Tulaga Va'a | La'uina i lalo ole vevela ole ambient |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'epa'e po'o le Toeitiiti Pa'epa'e Pa'u tioata |
Solubility | Solufua Saoloto i le Dimethylformamide, Solu Teisi i le Vai, Ethanol ma Methanol |
Faailoaina IR | Ole alaleo ole fa'ata'ita'iga e fetaui ma le tulaga fa'asino |
Fa'ailoga HPLC | O le taimi fa'atumauina o le fa'ata'ita'iga fa'ata'ita'iga e fetaui ma le tulaga fa'asino |
Suavai (e KF) | 5.5%~6.5% |
Fa'asinomaga Fa'ailo | +24.0° i le +30.0° (DMF: MeOH=1:1 C=1%) (i luga o mea e leai ni vai) |
Toega i luga o le mumu | ≤0.10% |
Mea Fa'atatau | |
Furoentecavir | ≤0.10% |
Entecavir 1-Epimer | ≤0.10% |
Entecavir 3-Epimer | ≤0.10% |
8-Methyoxy Entecavir | ≤0.10% |
Entecavir 4-Epimer | ≤0.10% |
8-Hydroxy Entecavir | ≤0.10% |
4-Dimethylsilyl Entecavir | ≤0.10% |
Entecavir Related Compound A | ≤0.10% |
So'o se mea le mama e le o ta'ua | ≤0.10% |
Aofa'i Fa'aleaga | ≤0.30% |
Solvents totoe | |
Methanol | ≤600ppm |
Dichloromethane | ≤300ppm |
Ethyl Acetate | ≤1000ppm |
Tetrahydrofuran | ≤720ppm |
Toluene | ≤890ppm |
Benzyl Chloride | ≤1000ppm |
Benzyl Alcohol | ≤1000ppm |
Tapulaa Microbial | |
Faitauga Aerobic Aofa'i | ≤100cfu/g |
Faafefete ma Molds | ≤10cfu/g |
Escherichia Coli | E le tatau ona iloa |
Metala mamafa | ≤10ppm |
Su'ega | 98.0% ~ 102.0% (HPLC; i luga o le anhydrous faavae) |
Lapo'a La'au | 95% o vaega e tatau ona i totonu ole 125um |
Tulaga Su'ega | Atina'e Atina'e;United States Pharmacopoeia (USP) Standard |
Fa'aoga | Antiviral vailaʻau faʻaaogaina i le togafitiga o Faʻamaʻi Hepatitis B |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
![1](https://www.ruifuchemical.com/uploads/15.jpg)
![](https://www.ruifuchemical.com/uploads/23.jpg)
O le Entecavir Monohydrate (CAS 209216-23-9) ose vaila'au fa'ama'i fa'ama'i e fa'aaogaina i le togafitia o fa'ama'i pipisi o le Hepatitis B Virus (HBV).Entecavir Monohydrate o se nucleoside analog (sili atu faapitoa, o se guanine analogue) e taofia ai le faʻaliliuina o le faʻaliliuga, DNA replication ma transcription i le vira.Ose ituaiga fou ole cyclopentyl acyl guanosine anti-Hepatitis B fa'ama'i fa'ama'i ma ona a'afiaga fa'afoma'i e tutusa ma le Entecavir.O lo'o fa'aogaina ile falema'i ile togafitiga ole Hepatitis B fa'ama'i matutua o lo'o iai fa'asologa fa'ama'i viral, fa'ateleina le serum transaminase ALT po'o manu'a gaogao na fa'aalia mai le fa'asologa o le ate.Entecavir Monohydrate o se inhibitor malosi ma filifilia o le HBV, faʻatasi ai ma le EC50 o le 3.75 nM i le HepG2 cell.O le Entecavir o se fa'ailoga fa'aliliuga fa'aliliu.E puipuia ai le Fa'ama'i Hepatitis B (HBV) mai le fa'ateleina ma fa'aitiitia le aofa'i o siama i totonu o le tino.
-
Entecavir Monohydrate CAS 209216-23-9 API Facto...
-
Entecavir CAS 142217-69-4 API Falegaosimea Maualuga Maualuga...
-
Ganciclovir CAS 82410-32-0 API BW 759 GCV Antiv...
-
Acyclovir CAS 59277-89-3 API Faleoloa Antiviral ...
-
Tiopronin CAS 1953-02-2 API Falegaosi Mea Maualuluga...
-
Sorafenib Tosylate CAS 475207-59-1 Mama ≥99.0...
-
Eflornithine Hydrochloride Monohydrate CAS 9602...
-
Darunavir Ethanolate CAS 635728-49-3 Mama ≥99...
-
Darifenacin Hydrobromide Darifenacin HBr CAS 13...
-
Dantrolene Sodium Salt Hydrate CAS 14663-23-1 A...
-
Daptomycin CAS 103060-53-3 Mama ≥95.0% API Fa...
-
Citicoline Sodium Salt Hydrate CAS 33818-15-4 A...
-
Cefotaxime Sodium Salt CAS 64485-93-4 Su'ega ≥91...
-
Cholestyramine CAS 11041-12-6 USP API Faleoloa H...
-
Cinchonidine CAS 485-71-2 Su'ega 98.5%~101.0% AP...