Ganciclovir CAS 82410-32-0 API BW 759 GCV Antiviral CMV Inhibitor Tulaga Maualuluga
Tuuina atu a le Faumea ma le Mamalu Maualuga ma le Tulaga Lelei
Igoa vaila'au: Ganciclovir
CAS: 82410-32-0
Antiviral Agent mo Togafitiga o le Cytomegalovirus (CMV) Infection
API Tulaga Maualuga, Gaosiga Fa'apisinisi
Igoa Vailaau | Ganciclovir |
Synonyms | GCV;BW 759;9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine;2-Amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-tasi;2'-Nor-2'-Deoxyguanosine |
Numera CAS | 82410-32-0 |
CAT Numera | RF-API82 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
Fuafua mole | C9H13N5O4 |
Molecular Weight | 255.23 |
Lisi Lisi | 250℃ |
Teuga vevela | 2-8 ℃ |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'epa'e i le Pa'u Pa'epa'e Pa'epa'e |
Solubility | E matua solu i le vai |
Fa'ailoaga | Ultraviolet absorption, infrared absorption |
Ma'imau ile Fa'amago | ≤6.0% |
Toega i luga o le mumu | ≤0.10% |
Mea Fa'atatau | Ganciclovir Related Compound A ≤0.50% |
Tapulaa o Guanine | ≤0.50% |
Solvents totoe (GC) | Ethanol ≤5000ppm |
Metala mamafa | ≤10ppm |
Fa'asa'o Fa'asa'o | 516-548 ile 252nm |
Endotoxins siama | ≤0.84EU/mg |
Su'ega | 98.0%~102.0% (Titration) |
Tulaga Su'ega | Atina'e Atina'e;United States Pharmacopoeia (USP) Standard |
Fa'aoga | API, CMV Inhibitor |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
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Ganciclovir (CAS 82410-32-0) o loʻo i totonu o vailaʻau faʻamaʻi nucleoside, o se ituaiga o mea e maua mai i le guanosine.O le Ganciclovir ose vaila'au fa'ama'i fa'amatua e fa'ailoa mo fa'ama'i pipisi o le cytomegalovirus (CMV) e mata'utia ai le va'ai po'o le ola i tagata mama'i fa'aletonu.E iai le alaleo lautele, maualuga le lelei o a'afiaga i le herpes virus ma o le vaila'au muamua-filifiliga mo le togafitiga o le cytomegalovirus fa'ama'i ma le malosi malosi i le hepatitis B virus ma le adenovirus fa'apea fo'i.O le homologue o le acyclovir (ACV) ma lona aafiaga antiviral e tutusa ma, ae sili atu le malosi nai lo le aciclovir, e sili atu le malosi o aʻafiaga i luga o le cytomegalovirus e fesoʻotaʻi ma maʻi AIDS.O lo'o fa'aogaina ile falema'i mo togafitiga ole vaega fa'aulu ma le fa'aleleia o tagata mama'i fa'aletonu (e aofia ai ma'i AIDS) fa'atasi ma le cytomegalovirus retinitis.E mafai foi ona faʻaaogaina mo le puipuia o faʻamaʻi cytomegalovirus mo tagata mamaʻi maua totoga totoga poʻo maʻi AIDS ma taunuuga lelei i le cytomegalovirus serology suega.
Ganciclovir (CAS 82410-32-0) o se faʻamaʻi sili ona lelei, maualalo-oona ma maualuga-selectivity virus inhibitor atiaʻe e le Syntex Company (United States).O le vailaʻau muamua lea ua faʻamaonia e le US FDA mo le togafitia o faʻamaʻi pipisi o le cytomegalovirus (CMV).O le Syntex ua tu'uina atu le aia tatau fa'apitoa o le gaosiga.Ia Iuni 1988, na faamaonia ai mo le taimi muamua lenei papamaa ina ia lisiina i Peretania, sosoo ai ma le faasolosolo ona faamaonia e Falani, le Iunaite Setete, Iapani, ma Siamani Sisifo, Italia ma Kanata ma isi atunuu.Seia oʻo i le faaiuga o Iuni 1999, ua faʻamaonia i le silia ma le 70 atunuu ma itulagi mo le puipuia o tagata mamaʻi immunodeficiency ma le cytomegalovirus faʻamaʻi o tagata mamaʻi o totoga toto.I le 2002, Ganciclovir tablets ua maua le faamaoniga a le FDA, ua avanoa nei.
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