Gefitinib CAS 184475-35-2 Mama>99.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o Gefitinib (CAS: 184475-35-2) faʻatasi ai ma tulaga maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Faʻatau Gefitinib ma mea faʻapitoa,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | Gefitinib |
| Synonyms | Gefitinib Free Base;Iressa;ZD1839;ZD-1839;N-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-(3-Morpholinopropoxy)quinazolin-4-Amine;N-(3-Chloro-4-Fluorophenyl)-7-Methoxy-6-[3-(4-Morpholinyl)propoxy]-4-Quinazolinamine |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 184475-35-2 |
| Fuafua mole | C22H24ClFN4O3 |
| Molecular Weight | 446.91 g/mol |
| Lisi Lisi | 194.0 i le 198.0 ℃ |
| Malosi | 1.322±0.06 g/cm3 |
| Suavai Solubility | E le mafai ona solu i le Vai |
| Solubility | Solu i le DMSO |
| Temp. | Temperature Potu |
| Va'a | Ambient |
| COA & MSDS | Avanoa |
| Amataga | Shanghai, Saina |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Tulaga Fa'atonu | I'uga |
| Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e | E usitaia |
| Ma'imau ile Fa'amago | <0.50% | 0.13% |
| Toega i luga o le mumu | <0.20% | 0.06% |
| Le mama nofofua | <0.10% | 0.09% |
| Aofa'i Fa'aleaga | <0.50% | 0.20% |
| Metala mamafa (Pb) | ≤10ppm | <10ppm |
| Mama / Suʻesuʻega Metotia | >99.5% (HPLC) | 99.80% |
| Alaleo Infrared | Ia ogatasi ma le Fauga | E usitaia |
| 1H NMR Alaleo | Ia ogatasi ma le Fauga | E usitaia |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
afifi:Fa'ato'aga Fa'alili, Ato pepa alumini, 25kg/Cardboard Drum, pe tusa ai ma mana'oga o tagata fa'atau.
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E leai se oloa o le a tu'uina atu i atunu'u e ono fete'ena'i ai ma pateni o lo'o iai.Ae peitai o le matafaioi mulimuli o loo taoto i le Faatau.
Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Tausaga Aafiaga?E sili atu nai lo le 15 tausaga o le poto masani i le gaosiga ma le auina atu i fafo o le tele o tulaga maualuga o vailaʻau faʻapitoa poʻo vailaʻau lelei.
Maketi Autu?Faʻatau atu i maketi i totonu o le atunuʻu, Amerika i Matu, Europa, Initia, Korea, Iapani, Ausetalia, ma isi.
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Tulaga leleiFaamautinoaga?Fa'atonuga lelei faiga.O meafaigaluega faʻapitoa mo suʻesuʻega e aofia ai le NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Fa'ata'ita'iga?O le tele o oloa e maua ai faʻataʻitaʻiga e leai se totogi mo le iloiloga lelei, o tau o felauaiga e tatau ona totogi e tagata faʻatau.
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Felauaiga?E ala ile Express (FedEx, DHL), ile Air, ile Sea.
Pepa?A maeʻa le faʻatau atu auaunaga: COA, MOA, ROS, MSDS, ma isi mea e mafai ona tuʻuina atu.
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Tulaga Totogi?Proforma invoice o le a lafo muamua pe a maeʻa le faʻamaoniga o le poloaiga, faʻapipiʻi a matou faʻamatalaga faletupe.Totogi e le T / T (Telex Transfer), PayPal, Western Union, ma isi.
| Fa'amatalaga Saogalemu | 24/25 - Aloese mai le fa'afeso'ota'i ma le pa'u ma mata. |
| HS Code | 2934999099 |
Gefitinib (CAS: 184475-35-2) o se vailaʻau faʻapitoa faʻapitoa e faʻatatau i le maʻi maʻi na atiaʻe e AstraZeneca, UK.O le vaila'au mole mole muamua mo le togafitia o le kanesa o le mama sela laiti.E galue e ala i le filifili fa'alavelaveina le ala fa'aliliuina fa'ailoga o le epidermal growth factor receptor tyrosine kinase (EGFR-TK).Epidermal growth factor (EGF) o se polypeptide e iai le tele mole mole vavalalata o le 6.45 × 103, lea e mafai ona tuʻufaʻatasia ma le epidermal growth factor receptor (EGFR) i luga o le membrane cell target e maua ai aʻafiaga o meaola.EGFR o le tyrosine kinase (TK).Pe a fusifusia i le EGF, e mafai ona faʻamalosia le faʻamalosia o le TK i le tino o loʻo mauaina, e mafua ai le autophosphorylation o toega o le tyrosine, ma tuʻuina atu faʻasalalauga faʻaauau i sela, e mafua ai le faʻateleina o le cell ma le eseesega.E tele le EGFR i totonu o le tino o le tagata ma e matua fa'aalia i tumama leaga.E ala i le polokaina o le ala faʻailoga EGFR i luga o le cell surface, gefitinib faʻalavelaveina le tuputupu aʻe o le tuma, metastasis ma le angiogenesis, ma e mafai ona faʻaosofia apoptosis o sela tumo.I le masina o Aukuso 2002, na muai maketiina ai le gefitinib i Iapani e avea o se togafitiga muamua mo le kanesa o le mama sela laiti i lalo o le igoa tau fefaatauaiga Iressa.I le masina o Me 2003, na fa'amaonia ai e le US Food and Drug Administration le gefitinib e avea ma monotherapy laina lona tolu mo tagata mama'i o lo'o maua i le kanesa o le mama mama e le'i la'ititi e le'i aoga i vaila'au fa'ama'i fa'ama'i ma le docetaxel chemotherapy.I le taimi nei, ua faʻamaonia e Ausetalia, Iapani, Atenitina, Sigapoa ma Korea i Saute mo le togafitia o le kanesa o le mama sela laiti.I le aso 28 o Fepuari, 2005, na faʻamaonia ai e le China Food and Drug Administration le gefitinib mo le togafitia o le kanesa o le mama o le tino poʻo le metastatic non-small cell lung (NSCLC) lea na maua muamua le chemotherapy.E le'o fa'atagaina i le taimi nei mo le fa'aaogaina e fai ma togafitiga muamua mo NSCLC maualuga.I le aso 1 o Iulai, 2009, na fa'amaonia aloaia ai e le European Medicines Agency le gefitinib mo le laina muamua, laina lona lua ma le laina lona tolu o togafitiga o le kanesa o le mama o le tino po'o le metastatic e le o ni tama'i sela fa'atasi ma suiga o gene EGFR i tagata matutua.
