Gemcitabine CAS 95058-81-4 Suʻega 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o Gemcitabine (CAS: 95058-81-4) faʻatasi ai ma le maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Gemcitabine,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | Gemcitabine |
| Synonyms | 2'-Deoxy-2',2'-Difluorocytidine;4-Amino-1-[3,3-Difluoro-4-Hydroxy-5-(Hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;dFDC;Gemzar (Lilly);LY-188011;dFdCyd;DDFC;2',2'-Difluoro-2'-deoxycytidine;2',2'-Difluorodeoxycytidine;Folfugem;GemLip;Gemcel;Gamcitabine |
| Tulaga Fa'asoa | I le fa'asoa, Gaosi Gaosi 5 Tone |
| Numera CAS | 95058-81-4 |
| Fa'atatau CAS | 122111-03-9 |
| Fuafua mole | C9H11F2N3O4 |
| Molecular Weight | 263.20 g/mol |
| Lisi Lisi | 217.0 i le 222.0 ℃ |
| Malosi | 1.84±0.10g/cm3 |
| Ma'ale'ale | Ma'ale'ale vevela |
| Suavai Solubility | E le mafai ona solu i le Vai |
| COA & MSDS | Avanoa |
| Amataga | Shanghai, Saina |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga | I'uga |
| Fa'aaliga | Pa'u Pa'epa'e pe Toeitiiti Pa'epa'e, E leai se manogi | E usitaia |
| Cytosine | ≤0.10% | 0.002% |
| α-Isomer | ≤0.10% | 0.01% |
| Le mama o le tagata lava ia | ≤0.10% | 0.03% |
| Aofa'i Fa'aleaga | ≤1.00% | 0.10% |
| Vai saunia e Karl Fischer | ≤1.00% | 0.67% |
| Ta'amilosaga Fa'apitoa | +68.0°~+74.0° | +70.5° |
| Metala mamafa | ≤10ppm | <10ppm |
| Toega i luga o le mumu | ≤0.10% | 0.03% |
| Su'ega (Saunia e HPLC) | 98.0%~102.0% | 99.9% |
| Alaleo Infrared | Ia ogatasi ma le Fauga | E usitaia |
| 1H NMR Alaleo | Ia ogatasi ma le Fauga | E usitaia |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
afifi:Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Taofi mau le koneteina ma teu i totonu o se faleteuoloa malulu, mago ma lelei le savili mai mea e le fetaui.Aloese mai le fa'aalia o le susulu o le la, susu ma le vevela tele.
Va'a:Tu'u atu ile lalolagi atoa ile ea, ile FedEx / DHL Express.Tuuina atu vave ma faatuatuaina tiliva.
Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Tausaga Aafiaga?E sili atu nai lo le 15 tausaga o le poto masani i le gaosiga ma le auina atu i fafo o le tele o tulaga maualuga o vailaʻau faʻapitoa poʻo vailaʻau lelei.
Maketi Autu?Faʻatau atu i maketi i totonu o le atunuʻu, Amerika i Matu, Europa, Initia, Korea, Iapani, Ausetalia, ma isi.
Tulaga lelei?Tulaga maualuga, tau taugofie, auaunaga faʻapolofesa ma lagolago faʻapitoa, vave tuʻuina atu.
Tulaga leleiFaamautinoaga?Fa'atonuga lelei faiga.O meafaigaluega faʻapitoa mo suʻesuʻega e aofia ai le NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Fa'ata'ita'iga?O le tele o oloa e maua ai faʻataʻitaʻiga e leai se totogi mo le iloiloga lelei, o tau o felauaiga e tatau ona totogi e tagata faʻatau.
Fale Su'etusi?Fa'afeiloa'i su'etusi falegaosimea.Fa'amolemole fai se taimi vave.
MOQ?Leai MOQ.Laititi oka e talia.
Taimi Tiliva? Afai o loʻo i totonu o faʻatauga, e tolu aso e faʻamaonia le tuʻuina atu.
Felauaiga?E ala ile Express (FedEx, DHL), ile Air, ile Sea.
Pepa?A maeʻa le faʻatau atu auaunaga: COA, MOA, ROS, MSDS, ma isi mea e mafai ona tuʻuina atu.
Tulaga Fa'apitoa?E mafai ona tu'uina atu au'aunaga tu'ufa'atasiga fa'apitoa e fetaui lelei ma au su'esu'ega mana'oga.
Tulaga Totogi?Proforma invoice o le a lafo muamua pe a maeʻa le faʻamaoniga o le poloaiga, faʻapipiʻi a matou faʻamatalaga faletupe.Totogi e le T / T (Telex Transfer), PayPal, Western Union, ma isi.
Fa'ailoga Tulaga R21 - E afaina pe a fa'afeso'ota'i ma pa'u
R36/38 - Fa'aitaita i mata ma pa'u.
R46 - E ono fa'atupuina fa'aleagaina fa'agatama
R62 - Fa'alavelave fa'aletonu o le fa'ato'aga
R63 - Fa'alavelave e ono afaina ai le pepe e le'i fanau mai
Fa'amatalaga Saogalemu S25 - Aloese mai le pipii i mata.
S26 - Pe a pa'i i mata, fufulu vave i le tele o vai ma saili fautuaga faafoma'i.
S36/37 - Fai ofu puipui ma totigilima talafeagai.
S53 - Aloese mai le fa'aalia - maua fa'atonuga fa'apitoa a'o le'i fa'aogaina.
HS Code 2934999091
Oona LD10 iv i isumu: 200 mg/m2 (Abbruzzese)
Gemcitabine (CAS: 95058-81-4) o se vailaʻau o le chemotherapy e faʻaaogaina e togafitia ai le tele o ituaiga o kanesa.E aofia ai le kanesa o le susu, le kanesa o le mama sela laiti, kanesa o le pancreatic, kanesa o le manava, ma le kanesa o le biliary tract.Gemcitabine o loʻo suʻesuʻeina mo le faʻaaogaina i le kanesa o le esophage, ma faʻaaogaina faʻataʻitaʻiga i lymphomas ma isi ituaiga tumo eseese.Gemcitabine o loʻo faʻatinoina e ala i le tui, talu ai e faʻateleina le faʻaogaina e le gastrointestinal tract.
Gemcitabine o se nucleotide analogue, lea e aofia i le vaega anti-metabolic o vailaʻau faʻamaʻi.E masani ona galue i le DNA synthesis vaega, o lona uiga, S vaega.I lalo o nisi tulaga, e mafai ona taofia le vaega G1 mai le alualu i luma i le vaega S.O lo'o i ai uiga o le lautele o alaleo anticancer, faiga tulaga ese o le gaioiga, maualalo oona, leai se fa'afeagai i isi vaila'au chemotherapy ma leai se fa'atuputeleina o le oona.Chemicalbook, gemcitabine, ua fa'amaonia nei mo le fa'aogaina i le silia ma le 90 atunu'u, ma avea ai ma togafitiga muamua mo le kanesa o le mama sela laiti ma le "tulaga auro" mo le kanesa pancreatic.
I le 1999, CFDA faʻamaonia gemcitabine mo togafitiga o le NSCLC maualuga poʻo metastatic i le lotoifale, faʻapitonuʻu maualuga poʻo metastatic pancreatic kanesa;I le 2010, CChemicalbookFDA faʻamaonia le gemcitabine faʻatasi ma le paclitaxel mo le togafitiga o le kanesa o le susu e le mafai ona faʻaaogaina, faʻasolosolo i le lotoifale poʻo le metastatic lea na toe tupu pe a maeʻa le chemotherapy adjuvant / neoadjuvant.
Gemcitabine o se antimetabolite lautele ma le deoxycytidine analogue faʻatasi ai ma gaioiga antineoplastic.I luga o le pulega, o le gemcitabine ua liua i metabolites malosi difluorodeoxycytidine diphosphate (dFdCDP) ma le difluorodeoxycytidine triphosphate (dFdCTP) e le deoxycytidine kinase.Ua tauva le dFdCTP ma le deoxycytidine triphosphate (dCTP) ma ua tu'ufa'atasia i le DNA.O le mea lea e loka ai le DNA polymerase e mafua ai ona faʻamutaina faʻagata i le taimi o le toe faia o DNA.I le isi itu, o le dFdCDP e taofia ai le ribonucleotide reductase, ma faʻaitiitia ai le vaitaele deoxynucleotide o loʻo avanoa mo DNA synthesis.O le faʻaititia o le intracellular concentration o le dCTP e faʻamalosia ai le tuʻufaʻatasia o le dFdCTP i le DNA.
