N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS 152460-09-8 Imatinib Mesylate Intermediate High mama.
Sapalai Faapisinisi Imatinib Mesylate ma Fesoota'iga Fa'atatau:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
Igoa Vailaau | N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine |
Synonyms | Imatinib Mesylate Intermediate;2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine |
Numera CAS | 152460-09-8 |
CAT Numera | RF-PI228 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
Fuafua mole | C16H13N5O2 |
Molecular Weight | 307.31 |
Lisi Lisi | 188.0~193.0 ℃ |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Samasama pe Toeitiiti Samasama Pata |
Mama | ≥98.0% (HPLC) |
Susū (KF) | ≤0.50% |
Aofa'i Fa'aleaga | ≤2.0% |
Avanoa Tasi Tumaoti | ≤1.0% |
Toega ile mu | ≤0.50% |
Metala mamafa | ≤20ppm |
Tulaga Su'ega | Enterprise Standard |
Fa'aoga | Intermediate of Imatinib Mesylate (CAS: 220127-57-1) |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua ma tuʻuina atu le N-(2-Methyl-5-nitrophenyl) -4-(pyridin-3-yl) pyrimidin-2-amine (CAS: 152460-09-8) ma tulaga maualuga.O se vaeluaga masani i le tuʻufaʻatasia o Imatinib Mesylate (CAS: 220127-57-1).
O le Imatinib Mesylate o se mole laʻititi e taofia ai le c-Abl protein-tyrosine kinase, Faʻapitoa mo le BCR-ABL, le enzyme e fesoʻotaʻi ma le leukemia myelogenous masani (CML) ma nisi ituaiga o leukemia lymphoblastic acute (ALL).O se fa'aliliuga fa'aliliuga i le va o chromosomes 9 ma le 22 e fa'atupuina ai le Philadelphia chromosome, ona maua ai lea o le Bcr-Abl fusion protein fa'atasi ai ma gaioiga aberrant kinase e fa'ateleina ai le fa'ateleina o sela.Imatinib Mesylate e fusifusia lenei kinase taua, taofia le tuputupu aʻe o le CML.Imatinib Mesylate ua faʻaalia atili e taofiofia le PDGFR ma tyrosine kinases e fesoʻotaʻi ma c-Kit.O faʻasologa o loʻo i ai le Imatinib Mesylate na faʻaaogaina i togafitiga o kanesa eseese.