N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate Mama maualuga
Sapalai Faapisinisi Imatinib Mesylate ma Fesoota'iga Fa'atatau:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Igoa Vailaau | N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea |
| Synonyms | Imatinib Mesylate Intermediate;2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine |
| Numera CAS | 152460-10-1 |
| CAT Numera | RF-PI230 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
| Fuafua mole | C16H15N5 |
| Molecular Weight | 277.32 |
| Lisi Lisi | 133.0-135.0 ℃ |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | moli moli i le samasama pauta i tioata |
| Mama / Suʻesuʻega Metotia | ≥98.0% |
| Ma'imau ile Fa'amago | ≤0.50% |
| Toega ile mu | ≤0.50% |
| Aofa'i Fa'aleaga | ≤2.0% |
| Avanoa Tasi Tumaoti | ≤1.0% |
| Metala mamafa | ≤20ppm |
| Tulaga Su'ega | Enterprise Standard |
| Fa'aoga | Intermediate of Imatinib Mesylate (CAS: 220127-57-1) |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua ma le tuʻuina atu o le N-(5-Amino-2-methylphenyl) -4-(3-pyridyl) -2-pyrimidinea (CAS: 152460-10-1) faʻatasi ai ma tulaga maualuga. .
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) o se vaeluaga masani i le tuʻufaʻatasia o Imatinib Mesylate (CAS: 220127-57-1). ) API.
Imatinib mesylate o se tamai mole e taofia ai le c-Abl protein-tyrosine kinase, o se kinase e taua tele mo le faʻateleina o le leukemia myelogenous masani (CML).O se fa'aliliuga fa'aliliuga i le va o chromosomes 9 ma le 22 e fa'atupuina ai le Philadelphia chromosome, ona maua ai lea o le Bcr-Abl fusion protein fa'atasi ai ma gaioiga aberrant kinase e fa'ateleina ai le fa'ateleina o sela.Imatinib mesylate e fusifusia ai lenei kinase taua, taofia le tuputupu aʻe o le CML.Imatinib mesylate ua faʻaalia atili e taofiofia le PDGFR ma tyrosine kinases e fesoʻotaʻi ma c-Kit.O faʻasologa o loʻo i ai le Imatinib mesylate na faʻaaogaina i togafitiga o kanesa eseese.
Imatinib mesylate o le tyrosine kinase inhibitor.Fa'apitoa mo le BCR-ABL, o le enzyme e feso'ota'i ma le lukimia myelogenous masani (CML) ma nisi ituaiga o ma'i lymphoblastic leukemia (ALL).Ose v-Abl tyrosine kinase inhibitor malosi ma filifili (IC50 = 38 nM).Fa'asa foi le PDGFR ma le c-kit.Fa'aalia le filifiliga mo v-Abl i luga o se laulau o isi tyrosine ma serine/threonine protein kinases.Filifilia faʻalavelave PDGF-faʻaosofia le tuputupu aʻe o v-abl-suia PB-3 sela ma v-sis-suia BALB/c 3T3 sela in vitro.Fa'aalia a'afiaga fa'aantitumor i isumu o lo'o maua ai sela AMuLV po'o BABL/c 3T3 v-sis.Taofi le toe faia o le SARS-CoV ma MERS-CoV in vitro (EC50 tau o 9.823 ma 17.689 μM, faasologa).
![4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate Mama maualuga](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)