Imatinib Mesylate CAS 220127-57-1 Su'ega 98.0%~102.0% Ph+CML API Falegaosi Mea Maualuluga
Sapalai Faapisinisi Imatinib Mesylate ma Fesoota'iga Fa'atatau:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Igoa Vailaau | Imatinib Mesylate (alpha fomu) |
| Synonyms | Imatinib Methanesulfonate;STI571 Mesylate;CGP-57148B |
| Numera CAS | 220127-57-1 |
| CAT Numera | RF-API19 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
| Fuafua mole | C30H35N7O4S |
| Molecular Weight | 589.71 |
| Tulaga Va'a | I lalo ole Temperature Ambient |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e i le Pa'u Pa'epa'e Pa'epa'e |
| Solubility | Faigofie ona solo i le vai |
| Fa'ailoga HPLC | Fa'ata'ita'i alaleo ole taimi fa'atumauina pito maualuga e ogatasi ma lena |
| IR Identification | Fa'ata'ita'i fa'ata'ita'iga fa'aa'ai ole alaleo ole fa'aaulaula ma fa'ata'ita'iga |
| Lisi Lisi | 214.0~222.0 ℃ |
| Ma'imau ile Fa'amago | ≤0.50% |
| Toega i luga o le mumu | ≤0.10% |
| Metala mamafa | ≤20ppm |
| Mea Fa'atatau | (1) Le mama G: NMT 0.3% |
| (2) Le mama B: NMT 0.3% | |
| (3) Le mama C: NMT 0.3% | |
| (4) Le mama D: NMT 0.3% | |
| (5) Le mama A: NMT 0.3% | |
| (6) Le mama H: NMT 0.3% | |
| (7) Le mama F: NMT 0.3% | |
| (8) Le mama E: NMT 0.3% | |
| (9) Le sili ona leaga tasi: NMT0.1% | |
| Solvents totoe | (1) Ethyl Acetate: NMT 5000ppm |
| (2) Methanol: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Ethanol: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| Su'ega HPLC | 98.0%~102.0% (C30H35N7SO4 Fa'atatau ile Fa'avae Anhydrous) |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | API;Ph+CML |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Imatinib Mesylate (CAS 220127-57-1) o se tamai mole e taofia ai le c-Abl protein-tyrosine kinase, o se kinase e taua tele mo le faʻateleina o le leukemia myelogenous masani (CML).Fa'apitoa mo le BCR-ABL, o le enzyme e feso'ota'i ma le lukimia myelogenous masani (CML) ma nisi ituaiga o ma'i lymphoblastic leukemia (ALL).Ose v-Abl tyrosine kinase inhibitor malosi ma filifili (IC50 = 38 nM).O se fa'aliliuga fa'aliliuga i le va o chromosomes 9 ma le 22 e fa'atupuina ai le Philadelphia chromosome, ona maua ai lea o le Bcr-Abl fusion protein fa'atasi ai ma gaioiga aberrant kinase e fa'ateleina ai le fa'ateleina o sela.Imatinib mesylate e fusifusia ai lenei kinase taua, taofia le tuputupu aʻe o le CML.Imatinib mesylate ua faʻaalia atili e taofiofia le PDGFR ma tyrosine kinases e fesoʻotaʻi ma c-Kit.
![4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate Mama maualuga](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)