Irinotecan Hydrochloride CAS 100286-90-6 Mama ≥99.0% (HPLC) API USP Fa'ata'ita'iga Mama maualuga
Faumea Faumea Sapalai Irinotecan ma Fesoota'iga Fa'atatau:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Igoa Vailaau | Irinotecan Hydrochloride |
| Synonyms | Camptothecin II;CPT-II |
| Numera CAS | 100286-90-6 |
| CAT Numera | RF-API50 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
| Fuafua mole | C33H39ClN4O6 |
| Molecular Weight | 623.15 |
| Lisi Lisi | 250-256℃ (Tes.) |
| Tulaga Teuteu | I lalo ole Temperature Ambient |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e po'o le Pa'epa'e Pa'epa'e |
| Solubility | Solu i le vai ma le methanol, soluble teisi i le chloroform, ethanol |
| Faailoaina IR | Ole alaleo ole absorption infrared ole fa'ata'ita'iga ole su'ega e tatau ona o gatasi ma le tulaga fa'asino |
| Fa'ailoga HPLC | Ole taimi fa'atumauina ole tumutumu tele ole vaifofo fa'ata'ita'i e tatau ona fetaui ma le tulaga fa'asino. |
| Fa'ailoaga | Faʻafeiloaʻi manaʻoga o suʻega mo le tali lelei ole Chloride |
| Susū (KF) | 7.0%~9.0% w/w |
| Toega i luga o le mumu | ≤0.10% |
| Metala mamafa | ≤20ppm |
| Irinotecan Hydrochloride Enantiomer | ≤0.10% (HPLC) |
| 7-Desetyl Irinotecan | ≤0.15% |
| Irinotecan Related Compound A | ≤0.15% |
| 11-Ethyl Irinotecan | ≤0.15% |
| Camptothecin | ≤0.15% |
| Irinotecan Related Compound B | ≤0.15% |
| 7-Ethylcanptothecin | ≤0.15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤0.15% |
| So'o se mea le mama e le o ta'ua | ≤0.10% |
| Aofa'i Fa'aleaga | ≤0.50% |
| Solvents totoe (GC) | |
| Methanol | ≤2000ppm |
| Acetone | ≤2000ppm |
| Dichloromethane | ≤500ppm |
| Peteoleum Eteru: | ≤100ppm |
| Ethyl Acetate | ≤2000ppm |
| Benzene | ≤2ppm |
| Endotoxins siama | ≤0.29 EU/mg Irinotecan |
| Tapulaa Microbial | Aofa'i Aerobic Microbial Faitau: <1000 cfu/g |
| Limu ma Faafefete | <100 cfu/g |
| Mama / Suʻesuʻega Metotia | ≥99.0% (HPLC, i luga o le faʻavae anhydrous) |
| Tulaga Su'ega | United States Pharmacopeia (USP) Standard |
| Fa'aoga | Mea Fa'afoma'i Gaoioiga (API) |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
lrinotecan hydrochloride (CAS 100286-90-6), o se semi-synthetic, vai soluble derivative o le malosi anticancer agent camptothecin, na faalauiloaina i Iapani mo togafitiga o mama, ovarian, ma kanesa faa'au'auna.E mafai e lrinotecan ona fa'atino ana gaioiga fa'atosina e ala i le taofiofia o le topoisomerase I, o se enzyme cellular lea e a'afia i le fa'atumauina o le fa'asologa o le DNA i le taimi o le fa'aliliuga, fa'aliliuga, ma le mitosis.lrinotecan e alu i le de-esterification in vivo e maua mai ai se metabolite malosi, SN-38, lea e 1000-sili atu le malosi nai lo le matua.O togafitiga faʻatasi o le irinotecan ma se isi vailaʻau faʻamaʻi faʻamaʻi lautele, cisplatin, ua lipotia mai e sili atu nai lo naʻo soʻo se sui.O lo'o iai le lrinotecan i su'esu'ega fa'apitoa mo le manava, susu, pa'u, colorectal, kanesa pancreatic, mesothelioma ma non-Hodgkin's lymphoma.
