Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 falegaosimea API Mama maualuga
Faumea Faumea Sapalai Irinotecan ma Fesoota'iga Fa'atatau:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Igoa Vailaau | Irinotecan Hydrochloride Trihydrate |
| Synonyms | Irinotecan HCl Trihydrate;CPT-11 Trihydrate;Irinotecan HCL 3H2O |
| Numera CAS | 136572-09-3 |
| CAT Numera | RF-API52 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
| Fuafua mole | C33H38N4O6·HCl·3H2O |
| Molecular Weight | 677.20 |
| Lisi Lisi | 250.0~256.0℃ (Tes.) |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Malamalama Samasama po'o Samasama Crystalline Powder |
| Su'ega (w/w) | 98.0%~102.0% |
| Mama (HPLC) | ≥99.5% |
| Solubility | Solu teisi i le vai, ethanol po'o le chloroform, Fa'ata'ita'i le mafai ona solu i le acetone |
| Fa'ailoaga | e le IR ma le HPLC, E tusa ai |
| Fa'asinomaga Fa'ailo | +60°~+73° |
| Vai | 7.0%~9.0% |
| Toega o Solvents | Faʻatasi ma Manaoga ICH |
| Toega i luga o le mumu | ≤0.20% |
| Klorida | 5.0%~6.0% |
| pH Taua | 3.0~5.0 |
| Metala mamafa | ≤20ppm |
| Fa'aleaga Ta'ito'atasi | ≤0.10% |
| Aofa'i Fa'aleaga | ≤0.50% |
| Tulaga Teuteu | Teu i le 2-8 ° C, I totonu o pusa faʻamaufaʻailoga ma puipuia mai le malamalama ma le susu |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | Mea Fa'afoma'i Gaoioiga (API) |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua ma le tuʻuina atu o le Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) faʻatasi ai ma le maualuga.
O le Irinotecan Hydrochloride Trihydrate o le topoisomerase I inhibitor e masani ona faʻaaogaina e togafitia ai le kanesa colon ma le kanesa rectal, e puipuia ai le faʻalagolago i le manoa DNA e ala i le fusia i le topoisomerase I-DNA lavelave.lrinotecan hydrochloride, o se semi-synthetic, vai soluble derivative o le malosi anticancer agent camptothecin, na faalauiloaina i Iapani mo togafitiga o mama, ovarian, ma kanesa faa'au'auna.E mafai e lrinotecan ona fa'atino ana gaioiga fa'atosina e ala i le taofiofia o le topoisomerase I, o se enzyme cellular lea e a'afia i le fa'atumauina o le fa'asologa o le DNA i le taimi o le fa'aliliuga, fa'aliliuga, ma le mitosis.lrinotecan e alu i le de-esterification in vivo e maua mai ai se metabolite malosi, SN-38, lea e 1000-sili atu le malosi nai lo le matua.E ui lava e sili atu le oona nai lo le camptothecin, ae o se numera tele o tagata mamaʻi i faʻataʻitaʻiga faʻataʻitaʻiga na faʻaalia ai aʻafiaga o le leukopenia, manava manava, nauseahromiting, ma alopecia.O togafitiga faʻatasi o le irinotecan ma se isi vailaʻau faʻamaʻi faʻamaʻi lautele, cisplatin, ua lipotia mai e sili atu nai lo naʻo soʻo se sui.O lo'o iai le lrinotecan i su'esu'ega fa'apitoa mo le manava, susu, pa'u, colorectal, kanesa pancreatic, mesothelioma ma non-Hodgkin's lymphoma.
