Ivabradine Hydrochloride CAS 148849-67-6 Mama>99.5% (HPLC) API Falegaosi
Ruifu Sapalai Vailaau Fa'asaina Ivabradine Hydrochloride Intermediates ma maualuga mama
Ivabradine Hydrochloride CAS 148849-67-6
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(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane Hydrochloride CAS 866783-13-3
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-tasi CAS 73942-87-7
7,8-Dimethoxy-3-(3-iodopropyl)-1,3-dihydro-2H-3-benzazepin-2-tasi CAS 148870-57-9
3-(3-Chloropropyl)-7,8-dimethoxy-1H-3-benzazepin-2(3H)-tasi CAS 85175-59-3
Igoa Vailaau | Ivabradine Hydrochloride |
Synonyms | Ivabradine HCl |
Numera CAS | 148849-67-6 |
CAT Numera | RF-PI1812 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
Fuafua mole | C27H36N2O5·HCl |
Molecular Weight | 505.05 |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'epa'e i le Pa'u Pa'epa'e Pa'epa'e |
Fa'ailoaga | HPLC/UV E tausisia |
Mama / Suʻesuʻega Metotia | >99.5% |
Ma'imau ile Fa'amago | <1.00% (Faamago i le 105 ℃ i totonu o se mea faʻamago ea eletise seʻia oʻo i le mamafa tumau) |
Susū Susū | <1.00% |
Toega i luga o le mumu | <0.20% |
Max nofofua le mama | <0.50% |
Aofa'i Fa'aleaga | <0.50% |
Isomer mata | <0.50% |
Su'ega | >99.5% |
Metala mamafa | <20ppm |
Ta'amilosaga Fa'apitoa | +6.5° ~ +8.5° (i luga ole fa'amamago, 1% fofo ile DMSO) |
Tulaga Su'ega | Pisinisi Tulaga |
Fa'aoga | API |
afifi: Fagu, ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu
Ivabradine Hydrochloride (CAS: 148849-67-6),I se taumafaiga e atiaʻe vailaʻau angina e aunoa ma le le manaʻomia o le inotropic ma le hypotensive aʻafiaga e fesoʻotaʻi ma le b-adrenergic blockers ma le calcium channel blockers, ua suʻesuʻeina se vasega fou o fatu faʻaitiitiga o loʻo galue faapitoa i le sinoatrial (SA) node.O nei vaila'au bradycardic fegalegaleai sa'o ma le pacemaking cell o le SA node ma le hyperpolarization-fa'agaoioia Afai o le pacemaking muamua o loʻo i ai nei.Ivabradine ua tupu aʻe e avea o se inhibitor faapitoa o le taimi nei e ala i lona faʻafesoʻotaʻi ma f-auala i luga o le itu intracellular o le membrane plasma.O se taunuuga, o le Ivabradine e faʻaitiitia ai le saoasaoa o le diastolic depolarization ma faʻaitiitia ai le fatu.Ua faʻamaonia mo le togafitia o le angina tumau tumau ma tuʻuina atu se avanoa talafeagai i tagata mamaʻi ma se faʻalavelave poʻo le le faapalepale o b-blockers.O lo'o fa'agasolo fo'i su'esu'ega mo togafitiga fa'aletonu ole fatu fatu.