LCZ696 Intermediate CAS 1426129-50-1 Mama ≥98.0% (HPLC) ee ≥99.0% Falegaosimea Mamalu Maualuga
Sapalai Pisinisi LCZ696 (CAS: 936623-90-4) Feso'ota'iga Fa'atatau:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium masima) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Faʻafefiloi Sacubitril ma Valsartan CAS: 936623-90-4
| Igoa Vailaau | (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate |
| Synonyms | LCZ696 Intermediate |
| Numera CAS | 1426129-50-1 |
| CAT Numera | RF-PI169 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
| Fuafua mole | C20H25NO3 |
| Molecular Weight | 327.42 |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e |
| Mama / Suʻesuʻega Metotia | ≥98.0% (HPLC) |
| Enantiomeric Excess | ee: ≥99.0% |
| Susū (KF) | ≤1.0% |
| Mea Fa'atatau A | ≤1.0% (RRT=0.5) A=(R)-3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol |
| Mea Fa'atatau B | ≤1.0% (RRT=0.85) B=Triphenylphosphine oxide |
| Isi Mea | ≤1.0% |
| Aofa'i Fa'aleaga | ≤2.0% |
| Tulaga Su'ega | Enterprise Standard |
| Fa'aoga | Intermediate o le LCZ696 (CAS: 936623-90-4) ile togafitiga ole HFrEF |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Faumea e maualuga le mama ma mautu lelei
Sapalai Pisinisi LCZ696 (CAS: 936623-90-4) Feso'ota'iga Fa'atatau:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium masima) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Faʻafefiloi Sacubitril ma Valsartan CAS: 936623-90-4
O le LCZ696 o se vailaʻau faʻataʻitaʻi na atiaʻe e Novartis Pharmaceutical o le Iunaite Setete mo le togafitia o tagata mamaʻi maʻi maʻi maʻi ma le faʻaitiitia o le Ejection Fraction (HFrEF).O le faaletonu o le fatu o se ma'i e lamatia ai le ola.E le mafai e le fatu o le tagata maʻi ona pamu le toto e tuʻuina atu i le tino, ma faʻaalia ai faʻamaoniga o le dyspnea, vaivai ma le taofiofia o le suavai lemu, ona faasolosolo malie lea ona faateleina, e matua afaina ai le lelei o le olaga.E mafai e le LCZ696 ona faʻaleleia le puipuiga faʻalenatura a le tino mai le faʻaletonu o le fatu, faʻapea foʻi ma le faʻateleina o le maualuga o peptides natriuretic ma isi peptides vasoactive endogenous, ma faʻalavelave ai le renin-angiotensin-aldosterone system (RAAS).LCZ696 ua tuʻufaʻatasia ma Novartis's Hypertension Medication (Diovan, igoa lautele: valsartan) ma le vailaʻau faʻataʻitaʻi AHU-377.AHU377 poloka le faiga o peptides e lua e nafa ma le faʻaititia o le toto.Diovan faʻaleleia le vasodilation ma faʻaosofia le tino e faʻamalo le sodium ma vai.
