Lesinurad (RDEA 594) CAS 878672-00-5 Mama >99.5% (HPLC) Su'ega 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o Lesinurad (RDEA 594) (CAS: 878672-00-5) ma le maualuga maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Lesinurad ma Intermediates,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | Lesinurad |
| Synonyms | 2-[[5-Bromo-4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-yl]thio]acetic Acid;2-[[5-Bromo-4-(4-Cyclopropyl-1-Naphthalenyl)-4H-1,2,4-Triazol-3-yl]thio]-Acetic Acid;RDEA 594;RDEA-594;RDEA594;Zurampic |
| Tulaga Fa'asoa | I Fa'atauga, Gaosiga Fa'apisinisi |
| Numera CAS | 878672-00-5 |
| Fuafua mole | C17H14BrN3O2S |
| Molecular Weight | 404.28 g/mol |
| Lisi Lisi | >171℃(Tes.) |
| Malosi | 1.72±0.10g/cm3 |
| COA & MSDS | Avanoa |
| Amataga | Shanghai, Saina |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Tulaga Fa'atonu | I'uga |
| Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e | Pa'u Pa'epa'e Pa'epa'e |
| Fa'ailoaga | Ole taimi fa'atumauina ole tumutumu tele ole fofo fa'ata'ita'iga e fetaui ile tulaga fa'asino | E usitaia |
| Vai saunia e Karl Fischer | <0.50% | 0.14% |
| Toega i luga o le mumu | <0.10% | 0.03% |
| Metala mamafa (Pb) | ≤10ppm | <10ppm |
| Mea Fa'atatau (HPLC) | ||
| Le sili ona leaga nofofua | <0.20% | 0.07% |
| Aofa'i Fa'aleaga | <1.00% | 0.24% |
| Mama / Suʻesuʻega Metotia | >99.5% (Vaega HPLC) | 99.76% |
| Su'ega | 98.0~102.0% | 99.6% |
| Alaleo Infrared | E tusa ma le Fauga | E usitaia |
| NMR Alaleo | E tusa ma le Fauga | E usitaia |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
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Lesinurad (RDEA 594) (CAS: 878672-00-5) na faʻamaonia e le US Food and Drug Administration (FDA) ia Tesema 22, 2015, ona faʻamaonia lea e le European Medicines Agency (EMA) i le Fepuari 18, 2016. na fausia muamua e Ardea le tuufaatasiga.Na maua e AstraZeneca le kamupani i le 2012, lea na maua ai le oloa.O le igoa tau fefa'ataua'iga o le vaila'au o le Zurampic® i le Iunaite Setete ma le Iuni a Europa.O le Lesinurad o le fa'auiluma muamua lea ua fa'amaonia e le lalolagi e fa'agata ai le toe fa'afo'i atu o le urate (URAT1), fa'atasi ma le iniseti o le xanthine oxidase e togafitia ai le gout e fa'atatau i le hyperuricemia.
Lesinurad, igoa fa'atau Zurampic.Lesinurad fa'atasi ma le xanthine oxidase inhibitor (XOI) mo le hyperuricemic gout syndrome.O lona faiga o le fesoasoani lea i fatuga'o e alu ese ai le uric acid, ma e galue e ala i le taofiofia o le galuega a tagata felauaiga o loʻo aʻafia i le toe faʻaleleia o le uric acid i fatugaʻo.
Lesinurad faʻalavelave le gaioiga o felauaiga o le uric acid (IC50 = 3.36 μM) o le hURAT1 (URAT1 tagata), lea e sili atu i le 20 taimi le faʻalavelave faʻalavelave i le rURAT1 (rat URAT1) (IC50 = 74.84 μM).Lesinurad faʻalavelave le hURAT1 e ala i fegalegaleaiga o le amino acid toega Phe365.
