Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 Maualuga Maualuga
Tuuina atu a le Faumea ma le Mamalu Maualuga ma le Tulaga Lelei
Igoa Vailaau: Lopinavir
CAS: 192725-17-0
O se mea e sili ona malosi, filifili peptidomimetic HIV-1 Protease Inhibitor
Oloa Su'esu'ega Fa'atatau ile COVID-19
API Tulaga Maualuga, Gaosiga Fa'apisinisi
Igoa Vailaau | Lopinavir |
Synonyms | LPV;ABT-378;Kaletra |
Numera CAS | 192725-17-0 |
CAT Numera | RF-API73 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
Fuafua mole | C37H48N4O5 |
Molecular Weight | 628.81 |
Teuga umi | Taofi umi i le 2-8 ℃ |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e |
Solubility | Solu fua ile Methanol ma ile Ethanol, Solu ile 2-Propanol |
Faailoaina IR | Ole alaleo ole absorption infrared ole fa'ata'ita'iga fa'ata'ita'iga e fetaui lelei ma le alaleo o fa'amatalaga masani |
Fa'ailoga HPLC | O le taimi fa'atumauina o le fa'ata'ita'iga fa'ata'ita'iga e fetaui ma le tulaga fa'asino |
Suavai (e KF) | ≤4.0% |
Fa'asinomaga Fa'ailo | -22.0° i le -26.0° |
Toega i luga o le mumu | ≤0.20% |
Metala mamafa | ≤20ppm |
Lisi Lisi | 124.0 i le 127.0 ℃ |
Sulphated Ash | ≤0.20% |
Solvent totoe (Ethanol) | ≤0.50% |
Mea Fa'atatau | (HPLC, Area%) |
Le mama 1 | |
Le mama B (RRT=0.07) | ≤0.20% |
Le mama I (RRT=1.10) | ≤0.20% |
So'o se isi mea le mama | ≤0.10% |
Le mama 2 | So'o se isi mea leaga ta'ito'atasi ≤0.10% |
Aofa'i Fa'aleaga mai le Fa'agasologa 1 ma le 2 | ≤0.70% |
Aofa'i Fa'aleaga | ≤1.0% |
Su'ega (e le HPLC) | 98.0%~102.0% |
Tulaga Su'ega | Pisinisi Tulaga |
Fa'aoga | Filifilia Peptidomimetic HIV-1 Protease Inhibitor, COVID-19 Fa'atatau i Su'esu'ega Oloa |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
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Lopinavir (ABT-378) ose peptidomimetic inhibitor sili ona malosi, filifilia o le HIV-1 protease, ma Kis o le 1.3 i le 3.6 pM mo le vao ma le mutant HIV protease.Lopinavir e galue e ala i le taofia o le matua o le HIV-1 ma taofia ai lona faʻamaʻi pipisi.Lopinavir ose SARS-CoV 3CLpro inhibitor ma le IC50 o le 14.2 μM.Lopinavir ose antiretroviral o le protease inhibitor vasega.O le taofiofia o le HIV-1 protease e taofia ai le malepelepe o le viral polyprotein precursor ma iu ai i le faʻasaʻolotoina o virions e le o matua, e le faʻamaʻi.O se vaega o togafitiga tu'ufa'atasi e togafitia ai le HIV/AIDS.Lopinavir, o le HIV protease inhibitor lona ono i le vasega "navir", na faʻalauiloaina i le faʻatasi ma ritonavir, o le isi HIV protease inhibitor ua uma ona maketiina (Abbott, 1996);na faʻaofiina lenei faʻavae muamua e pei o Kaletra mo le faʻaaogaina faʻatasi ma le nucleoside poʻo le non-nucleoside reverse transcriptase inhibitors mo le togafitia o le AIDS i tagata matutua ma tamaiti.O le Lopinavir o se peptidomimetic compound ma se faʻavae faʻavae e tutusa ma le ritonavir, lea na faʻapipiʻiina ai vaega faʻamau, aemaise lava se valine faʻaleleia, e ala i faiga faʻapipiʻi peptide.Lopinavir ose fa'atauva malosi fa'atauva'a ole HIV-I protease e fa'aalia ai le maualuga o le malosi e fa'asaga i suiga e fa'asalaina ritonavir.I le tele o ituaiga o meaola, suʻesuʻega pharmacokinetic ma le lopinavirlritonavir association na faʻaalia ai o mea tauagafau o lopinavir na matua faʻaleleia i le i ai o ritonavir, i le tulaga o le Cmax ma le umi o le gaioiga.
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