Losartan Potassium CAS 124750-99-8 API Falegaosimea Antihypertensive maualuga mama.
Tuuina atu le Losartan Potassium ma Fesoʻotaʻiga Fesoʻotaʻi ma le Tulaga Maualuga
Losartan Potassium CAS 124750-99-8
2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9
| Igoa Vailaau | Losartan potassium |
| Synonyms | DuP 753;Cozaar;2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Salt |
| Numera CAS | 124750-99-8 |
| CAT Numera | RF-API98 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
| Fuafua mole | C22H22ClKN6O |
| Molecular Weight | 461.01 |
| Lisi Lisi | 263.0~265.0 ℃ |
| Solubility | Solufua Sa'oloto ile Suavai ma Methanol, La'ititi Solu ile Acetonitrile. |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e po'o le Toeitiiti Pa'epa'e Pa'u tioata |
| Faailoaina A | Infrared Absorption: E tatau ona tutusa ma Faʻamaumauga Faʻamatalaga |
| Faailoaga B | Ultraviolet absorption: E tatau ona tutusa ma Reference Standard |
| Su'ega mo le potassium | E tatau ona lelei |
| Suavai (KF) | ≤0.50% |
| Metala mamafa | ≤10ppm |
| Mea Fa'atatau (HPLC) | |
| So'o se Fa'aleaga Ta'ito'atasi | ≤0.20% |
| Aofa'i Fa'aleaga | ≤0.50% |
| Solvents totoe (GC) | |
| Cyclohexane | ≤0.10% |
| Isopropyl Alcohol | ≤0.20% |
| Metotia o Su'esu'ega/Su'esu'ega | 98.5~101.0% (HPLC, fuafuaina i luga o le anhydrous, solvent-free faavae) |
| N-Nitrosodiethylamine | ≤0.177ppm (NDEA) |
| N-Nitrosodimethylamine | ≤0.640ppm (NDMS) |
| Lapo'a La'au | 90% I lalo ifo o le 38 Microns |
| Ola Fa'asa | 24 masina |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | API, Angiotensin II Receptor Antagonist Antihypertensive |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
O le Losartan Potassium o le muamua malosi ma le filifilia e le peptide angiotensin II receptor type 1 (AT1) antagonist na faʻafeiloaʻi i le maketi e avea o se faʻamaʻi faʻamaʻi faʻamaʻi i aso taʻitasi.O le faʻatonuga e taofia ai le 50% o le fusifusia o le angiotensin II (IC50) e 20 nM.Losartan (40 μM) e aʻafia ai le ISC ae puipuia le aafiaga ole ANGII ile ISC.O le Losartan e fa'aitiitia ai le fa'atuputeleina o sela e fa'asalalauina Ang II i sela o le kanesa endometrial.O le tu'ufa'atasiga o losartan ma le anti-miR-155 o lo'o i ai se a'afiaga e sili atu le fa'aleagaina pe a fa'atusatusa i vaila'au ta'itasi.E metabolized e maua ai le 5-carboxylic acid metabolite (EXP3174) ma ua lipotia mai e faʻaititia ai le toto.O loʻo suʻesuʻeina nei e avea o se togafitiga faʻapitoa mo le COVID-19 mo lona gafatia e faʻaititia pe ono faʻaitiitia ai faʻamaoniga o le COVID-19.
1. Mo le togafitia o le maualuga o le toto maualuga, e mafai ona faʻaaogaina naʻo ia pe faʻatasi ma isi vailaʻau faʻamalosi (e pei o le diuretics).2. Mo le togafitiga o le faaletonu o le fatu, e mafai ona faʻaaogaina naʻo ia pe faʻatasi ma le cardiotonic poʻo le diuretic Chemicalbook vailaʻau.3. Puipuia le stroke i gasegase e maua i le toto maualuga ma le agavale ventricular hypertrophy.4. E faʻaaogaina e faʻagesegese ai le alualu i luma o le nephropathy i tagata mamaʻi e maua i le maʻisuka ituaiga 2 e fesoʻotaʻi ma le nephropathy ma le toto maualuga.
