Methyl 2-Oxoindoline-6-Carboxylate CAS 14192-26-8 Mama >99.0% (HPLC) Nintedanib Esylate Intermediate Factory

Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) o se vaeluaga e faʻaaogaina e saunia ai le Nintedanib Esylate (CAS: 656247-18-6).O le Nintedanib Esylate o se mea malosi, oral triple angiokinase inhibitor na atiina ae e Boehringer Ingelheim lea e taulaʻi i auala proangiogenic ma pro-fibrotic e faʻatalanoaina e le vascular endothelial growth factor receptor, fibroblast growth factor receptor ma plateletderived growth factor receptors aiga, faʻapea foʻi ma Src ma Flt-3 kinase.Nintedanib Esylate na faʻamaonia mo togafitiga o le idiopathic pulmonary fibrosis (IPF), o se tulaga e faʻasolosolo ai le maʻila o mama i le aluga o taimi, e le US FDA ia Oketopa 2014 ma le EMA ia Ianuari 2015. Na tuʻuina atu e le FDA le nintedanib esylate fast-track. , iloiloga fa'amuamua, oloa matuaoti, ma fa'ailoga iloga.Na fa'amaonia fo'i e le EMA ia Novema 2014 mo le togafitia o le kanesa o le mama sela e le o ni sela laiti fa'atasi ma le docetaxel pe a mae'a le chemotherapy.