Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8 PF-07321332 Boceprevir Intermediate

Fa'amatalaga Puupuu:

Igoa Vailaau: Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl] propanoate

CAS: 328086-60-8

Fa'aaliga: Pa'epa'e i le Pa'epa'e Pa'epa'e

Intermediate of PF-07321332 Paxlovid (CAS 2628280-40-8) ma Boceprevir (CAS 394730-60-0)

Tulaga Maualuga, Gaosiga Fa'apisinisi

Inquiry: alvin@ruifuchem.com

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Fa'amatalaga Oloa

Oloa Fa'atatau

Faailoga o oloa

Fa'amatalaga:

Fa'atauga Fa'atauga PF-07321332 Paxlovid Feso'ota'i Tulaga Fa'atasi ma le Tulaga Maualuga
L-tert-Leucine (H-Tle-OH) CAS 20859-02-3
Caronic Anhydride CAS 67911-21-1
(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride 565456-77-1
Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8
6,6-Dimethyl-3-azabicyclo[3.1.0]hexane CAS 943516-54-9

Meatotino tau vailaau:

Igoa Vailaau	Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate
Synonyms	Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl) propanoate;(αS,3S)-α-[(tert-Butyloxycarbonyl)aMino]-2-oxo-3-pyrrolidinepropanoic acid Methyl Ester;(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl) propanoate
Numera CAS	328086-60-8
CAT Numera	RF-PI317
Tulaga Fa'asoa	I Fa'atauga, Oloa Fua e O'o i le selau Kilograms
Fuafua mole	C13H22N2O5
Molecular Weight	286.33
Fa'ailoga	Ruifu Chemical

Fa'amatalaga:

Aitema	Fa'amatalaga
Fa'aaliga	Pa'epa'e i le Pa'epa'e Pa'epa'e
Faailoaina A	IR: E tutusa ma Reference Substance
Faailoaga B	Taimi Taofi: Tutusa ma Mea Fa'asino
Ma'imau ile Fa'amago	≤1.0%
Toega i luga o le mumu	≤0.20%
Le mama nofofua	≤0.50%
Aofa'i Fa'aleaga	≤2.0%
Metala mamafa (Pb)	≤20ppm
Mama	≥98.0%
Tulaga Su'ega	Pisinisi Tulaga
Fa'aoga	Intermediate of PF-07321332 Paxlovid (CAS 2628280-40-8) ma Boceprevir (CAS 394730-60-0)

Paket & Teuina:

afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.

Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.

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Talosaga:

Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate (CAS 328086-60-8) o le vaeluaga o le PF-07321332 Paxlovid (CAS 2628280-40) -8) ma Boceprevir (CAS 394730-60-0).PF-07321332, o le vaega autu o Paxlovid (PF-07321332 ma Ritonavir) o se suʻesuʻega COVID-19 oral antiviral sui tauva, o se 3C-like protease (3CLPRO) e mafai ona tuʻu gutu faʻalavelave faʻatasi ma aʻafiaga malosi faʻamaʻi e faasaga i le siama SARS-CoV-2. ma le COVID-19.I le aso 6 o Novema 2021, na fa'ailoa mai ai e Pfizer o Paxlovid na fa'aititia tele le falema'i ma le maliu, fa'avae i luga o se su'esu'ega le tumau o le Vaega 2/3 EPIC-HR (Evaluation of Protease Inhibition for COVID-19 in High-Risk Patients) fa'afuase'i, su'esu'ega fa'alua tauaso. o tagata matutua e lei falemaʻi ma le COVID-19, o loʻo i ai i le maualuga o le lamatiaga o le alualu i luma i gasegase ogaoga.Boceprevir (EBP-520) ose HCV protease inhibitor (Ki=14 nM) mo le togafitia o le hepatitis C siama siama.Boceprevir faʻatasi ai ma le pegylated interferon ma ribavirin (PegIFN / RBV) na mafai ai ona faʻaleleia le faʻaleleia o fua faatatau o tali virological o tagata mamaʻi e maua i le genotype 1 HCV.Boceprevir fegalegaleai ma immunosuppressive togafitiga (IT) e ala i le taofia o le cytochrome P450 3A enzyme.