Molnupiravir (EIDD-2801) CAS 2349386-89-4 COVID-19 API Tulaga Maualuga
Sapalai Fefa'ataua'iga Molnupiravir ma Feso'ota'i Fesoota'i ma Tulaga Maualuga
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Molnupiravir (EIDD-2801) CAS 2349386-89-4
| Igoa Vailaau | Molnupiravir (EIDD-2801) |
| Synonyms | MK-4482;β-D-N4-Hydroxycytidine-5′-isopropyl ester;((2R,3S,4R,5R)-3,4-dihydroxy-5-(E)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2 -yl)methyl isobutyrate |
| Numera CAS | 2349386-89-4 |
| CAT Numera | RF-API97 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
| Fuafua mole | C13H19N3O7 |
| Molecular Weight | 329.31 |
| Solubility | Solu i le DMSO |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e |
| Faailoaina IR | Fa'ata'ita'i Alaleo e fetaui ma le tulaga fa'asino |
| Fa'ailoga HPLC | Ole taimi fa'atumauina ole tumutumu tele ole fofo fa'ata'ita'i e fetaui ma le vaifofo masani |
| Mea Fa'atatau | |
| Le mama A | ≤0.15% |
| Le mama B | ≤0.15% |
| So'o se mea le mama e le o ta'ua | ≤0.15% |
| Aofa'i Le Fa'amamafaina | ≤0.30% |
| Aofa'i Fa'aleaga | ≤0.50% |
| Solvents totoe | |
| N-Heptane | ≤5000ppm |
| Ethanol | ≤5000ppm |
| Isopropyl Acetate | ≤5000ppm |
| Acetonitrile | ≤410ppm |
| Methylene Dichloride | ≤600ppm |
| Acetone | ≤5000ppm |
| Isopropanol | ≤5000ppm |
| Suavai (KF) | ≤0.50% |
| Toega i luga o le mumu | ≤0.10% |
| Vaitaimi Mata | -7.5° i le -9.5° (C=0.5, Methanol) |
| Metala mamafa | ≤10ppm |
| Mama / Suʻesuʻega Metotia | ≥99.5% (230nm) |
| Su'ega / Su'esu'ega Metotia | 98.0%~102.0% (HPLC ile fa'amamago) |
| Ola Fa'asa | 24 masina |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | API, Molnupiravir (EIDD-2801) COVID-19 Taofi |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
O le Molnupiravir (EIDD-2801, MK-4482) o se vailaʻau faʻaola e mafai ona tuʻu tautala o le ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) faʻatasi ai ma le lautele o alaleo antiviral gaioiga e faasaga i le SARS-CoV-2, MERS-CoV, SARS-CoV, ma le so'o fa'atupu ole COVID-19.Molnupiravir o loʻo faʻatau atu i lalo o le igoa Lagevrio ma e masani lava o le emorivir.Molnupiravir ua faʻaalia e faʻaleleia le gaioiga o le mama, faʻaitiitia le mamafa o le tino ma faʻaitiitia le aofaʻi o siama i totonu o le mama.I le faaopoopo atu i gaioiga faasaga i coronaviruses, Molnupiravir, i suʻesuʻega suʻesuʻe, ua faʻaalia le gaioiga e tetee atu ai i le vaitau ma le faʻamaʻi manu, respiratory syncytial virus, chikungunya virus, Ebola virus, Venezuelan equine encephalitis virus, ma Eastern equine encephalitis virus.O le Molnupiravir na amataina e togafitia ai le influenza i le Iunivesite o Emory e le kamupani fou a le iunivesite, Drug Innovation Ventures i Emory (DRIVE), ae na lipotia mai na lafoaia ona o popolega i le mutagenicity.Ona maua lea e le kamupani a Miami Ridgeback Biotherapeutics, lea na mulimuli ane faipaaga ma Merck & Co. e atiina ae atili le fualaau faasaina.Molnupiravir na faʻamaonia mo le faʻaaogaina faafomaʻi i Peretania ia Novema 2021.
