N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Mama>99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) o se vaeluagalemu i le tuufaatasiga o Afatinib Dimaleate (CAS: 850140-73-7) .Afatinib Dimaleate o se masima masima o Afatinib.Afatinib o se augatupulaga lona lua, tuʻuina tautala, faʻalavelave le mafai ona faʻaaogaina o le aiga ErbB o tyrosine kinases.Mechanism of ActionAfatinib downregulates ErbB signaling by covalently binding to the kinase domains of epidermal growth factor receptor (EGFR), tagata epidermal growth factor receptor (HER) 2 ma le HER4, e mafua ai le le mafai ona toe faʻaaogaina o le tyrosine kinase autophosphorylation;e taofia ai foi le transphosphorylation o le HER3.Afatinib ua faʻamaonia e pei o le monotherapy mo le togafitiga o le EGFR tyrosine kinase inhibitor (TKI) -naive tagata matutua ma le faʻapitonuʻu i luma poʻo le FaʻamatalagaChEBI: O se masima maleate e maua e ala i le tuʻufaʻatasia o le afatinib ma le lua molar tutusa o maleic acid.Fa'aaogaina mo le laina muamua o togafitiga o tagata mama'i e maua i le kanesa o le mama sela e le o ni metastatic.