N-Acetyl-L-Tyrosine CAS 537-55-3 (Ac-Tyr-OH; NALT) Su'ega 99.0~101.0 Falegaosimea
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua ma tuʻuina atu le N-Acetyl-L-Tyrosine (Ac-Tyr-OH; NALT) (CAS: 537-55-3) faʻatasi ai ma le maualuga.Ruifu Chemical o lo'o tu'uina atu se fa'asologa o amino acids ma mea e maua mai ai.O oloa aupito maualuga, tau talafeagai, lelei ma vave le auaunaga pe a uma ona faatau atu o tautinoga ia a Ruifu Chemical i tagata faatau.E mafai ona matou tuʻuina atu COA, faʻasalalauga i le lalolagi atoa, laʻititi ma le tele o loʻo avanoa.Afai e te fiafia i le N-Acetyl-L-Tyrosine,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | N-Acetyl-L-Tyrosine |
| Synonyms | Ac-Tyr-OH;Ac-L-Tyr-OH;N-Ac-L-Tyr;NALT;Ac-Tyrosine;Acetyltyrosine;N-Acetyltyrosine;Acetyl-Laevo-Tyrosine;LN-Acetyltyrosine;(2S)-2-(Acetylamino)-3-(4-Hydroxyphenyl)Propanoate;(S)-2-Acetamido-3-(4-Hydroxyphenyl)propanoic Acid;N-Acetyl-(S)-2-Amino-3-(4-Hydroxyphenyl)propionic Acid;(2S)-2-(Acetylamino)-3-(4-Hydroxyphenyl)propanoic Acid |
| Tulaga Fa'asoa | I Fa'atauga, Gaosi Gaosi 30 Tone i le Tausaga |
| Numera CAS | 537-55-3 |
| Fuafua mole | C11H13NO4 |
| Molecular Weight | 223.23 g/mol |
| Lisi Lisi | 150.0 i le 154.0 ℃ |
| Malosi | 1.304 |
| Suavai Solubility | Solu i le Suavai, Toeititi lava manino |
| Temp. | Faamaufa'ailoga i le mago, teu i le vevela o le potu |
| COA & MSDS | Avanoa |
| Fa'avasegaga | Amino Acids & Derivatives |
| Fa'ailoga | Ruifu Chemical |
| Laiti o lamatiaga | Xi - Itaita | F | 10 |
| Fa'amatalaga Tulaga lamatia | 41-36/37/38 | TSCA | Ioe |
| Fa'amatalaga Saogalemu | 26-39-36 | HS Code | 2922491990 |
| WGK Siamani | 3 |
| Aitema | Tulaga Fa'atonu | I'uga |
| Fa'aaliga | Maila Pa'epa'e po'o le Pa'u tioata | Fa'atatau |
| Fa'ailoaga | Fusi Alaleo Fa'a'aalaula | Fa'atatau |
| Ta'amilosaga Fa'apitoa [α]20/D | +46.5° i le +49.0°(C=2 i H2O) | +47.2° |
| Tulaga o Fofo (Transmittance) | ≥96.0% | 98.3% |
| Klorida (Cl) | ≤0.020% | <0.020% |
| Sulfate (SO4) | ≤0.020% | <0.020% |
| Ammonium (NH4) | ≤0.020% | <0.020% |
| Uamea (Fe) | ≤30ppm | <30ppm |
| Metala mamafa (Pb) | ≤10ppm | <10ppm |
| Arsenic (As2O3) | ≤2.0ppm | <2.0ppm |
| Tyrosine | ≤1.00% | Fa'atatau |
| Ma'imau ile Fa'amago | ≤0.50% | 0.25% |
| Toega ile mumu (Sulfated) | ≤0.10% | 0.07% |
| Su'ega | 99.0 i le 101.0% | 99.5% |
| pH Taua | 2.0 i le 3.0 | 2.3 |
| Fa'ai'uga | Faʻafeiloaʻi le tulaga o le AJI97, USP35 | |
| Fa'aoga Autu | Mea'ai Fa'aopoopo;Mea'ai faaopoopo;Vailaau Fa'atekonolosi | |
N-Acetyl-L-Tyrosine (Ac-Tyr-OH; NALT) (CAS: 537-55-3) Metotia Suʻega AJI97
N-Acetyl-L-Tyrosine, pe a faʻamago, e le itiiti ifo i le 99.0 pasene ae le sili atu ile 101.0 pasene ole N-Acetyl-L-Tyrosine (C11H13NO4).
Fa'amatalaga: O tioata pa'epa'e po'o le pa'u tioata, malosi le tofo oona
Solu saoloto i le vai.
Solubility (H2O, g/100g): 17.5 (20℃), 72.4 (40℃), 158 (60℃)
Fa'ailoaina: Fa'atusatusa le fusi o le fa'ata'ita'i fa'ata'ita'i fa'atasi ma le fa'ata'ita'iga e ala i le metotia tisiketi o le potassium bromide.
Ta'amilosaga Fa'apitoa [α]20/D: Fa'ata'ita'i mago, C=4, H2O
Setete o Fofo (Transmittance): 0.5g i le 10ml o le H2O, spectrophotometer, 430nm, 10mm mafiafia sela.
Chloride (Cl): 0.7g, A-1, ref: 0.40ml o le 0.01mol/L HCl
Ammonium (NH4): B-1
Sulfate (SO4): 1.2g, (1), ref: 0.50ml o le 0.005mol/L H2SO4
Uamea (Fe): 0.5g, ref: 1.5ml o Iron Std.(0.01mg/ml)
Metala Mamafa (Pb): 2.0g, (3), ref: 2.0ml o Pb Std.(0.01mg/ml)
Arsenic (As2O3): 1.0g, (1), ref: 2.0ml o As2O3 Std.
Ma'imau ile fa'agogo: ile 105℃ mo le 3 itula
Toega i luga o le mumu (Sulfated): Su'ega AJI 13
Su'ega: Fa'ata'ita'iga mago, 300mg, (1), 40ml H2O, (2), 0.1mol/L NaOH, 1ml=22.323mg C11H13NO4
Tyrosine: chromatography sua.Tulaga gaogao: Su'esu'e: UV absorption photometer (214nm);Koluma: ODS, 4.6mm x 150mm;Malo o le Koluma: Tevela o le potu.Fuafuaga tafe: 1ml / min;Vaega feavea'i: 0.04mol/L fofo ole monopotassium phosphate (pH 4.35): Methanol (193:3)
pH: 1.25g ile 50ml ole H2O
Fautuaina tapula'a ma tulaga e teu ai: Fa'asaoina atigi pusa i le vevela o le potu (2 tausaga).
N-Acetyl-L-Tyrosine (Ac-Tyr-OH; NALT) (CAS: 537-55-3) USP35 Metotia Su'ega
FAAMATALAGA
N-Acetyltyrosine o loʻo i ai le NLT 98.5% ma le NMT 101.0% o le C11H13NO4, e pei o le N-Acetyl-L-Tyrosine, faʻatatau i luga o le faʻamago.
FAATINOGA
A. FA'AULA'I INFRARED <197K>
B. FILI'IGA FA'ATA'ITA'I, Ta'amilosaga Fa'apitoa <781S>
Fa'ata'ita'iga fofo: 10 mg/mL
Tulaga taliaina: NLT +46.0° ma le NMT +49.0°, fuafuaina ile 20°
C. O le tau RF o le nofoaga autu o le fofo Faʻataʻitaʻiga i le suʻega mo Organic Impurities e fetaui ma le faʻasologa masani 1.
SU'ESU'EGA
TULAGA
Fa'ata'ita'iga vaifofo: Fa'amuta pe tusa ma le 180 mg o le N-Acetyltyrosine, fuaina, i le 50 mL o le vai e leai se carbon dioxide.
Titrimetric faiga
(Siaki Titrimetry <541>)
Auala: Fa'asaga sa'o
Titrant: 0.1 N sodium hydroxide VS
Su'esu'ega pito: Potentiometric
Tulaga tutusa: O mL ta'itasi o le 0.1 N sodium hydroxide VS e tutusa ma le 22.32 mg o le C11H13NO4.
LELEI
Fa'aleaga Fa'aletino
TULAGA FA'AVAE <281>: NMT 0.1%
KOLOTI MA LE SULFATE, KLORIDA <221> NMT 200 ppm.Ole vaega ole 0.7-g e le sili atu le chloride nai lo le 0.40 mL ole 0.01 N hydrochloric acid.
CHLORIDE MA SULFATE, Sulfate <221> NMT 200 ppm.Ole vaega ole 1.2-g e fa'aalia e le sili atu le sulfate nai lo le tutusa ma le 0.25 mL ole 0.020 N sulfuric acid.
Umea <241>: NMT 20ppm
METAL MAMAFA, Metotia I <231>: NMT 10ppm
Oona Fa'aleaga
TULAGA
Adsorbent: 0.25-mm apa o chromatographic silica gel paluga
Fofo fa'asoa masani 1: 8 mg/mL o le USP N-Acetyl-L-tyrosine RS i se fa'afefiloi o le vai, fa'a'aisa acetic acid, ma le ava malosi (3:3:94)
Fofo masani 1: Fa'afefete le vaifofo masani 1 i le ava malosi ina ia maua ai se vaifofo o lo'o i ai se fa'atonuga iloa e tusa ma le 0.4 mg/mL.
Fofo masani 2: 0.8 mg/mL o le USP L-Tyrosine RS fa'amavae ile fa'afefiloi ole acetic acid ma le vai (1:1), ma fa'afefiloi ile ava malosi.
Fa'ata'ita'iga vaifofo: Fa'aliliu le 0.8 g o le N-Acetyltyrosine i se fagu volumetric 10-mL, fa'amavae i le 6 mL o le fa'afefiloi o le suka acetic acid ma le vai (1: 1), ma fa'afefiloi i le ava malosi i le voluma.
Ole tele ole talosaga: 5 µL
Fa'atupuina o le solvent system: Fa'afefiloi o ammonia ma le 2-propanol (3:7)
Fa'asu'u mea fa'afefe: Fa'amuta le 0.2 g o le ninhydrin i le 100 mL o le fa'afefiloi ole butanol ma le 2 N acetic acid (95:5).
Faiga talafeagai
Mana'oga talafeagai: O le chromatogram o le Fa'atonuga fa'aoga fofo o lo'o fa'aalia ai ni vaega manino se lua.
Iloiloga: Fa'aauau e pei ona fa'atonuina mo Chromatography <621> Thin-Layer Chromatography.A maeʻa le faʻamago o le ipu, toe fai le faagasologa o le atinaʻe.A mae'a fa'amago le ea mo le taimi lona lua, fa'afefe i le Spray reagent, ma vevela i le va o le 100° ma le 105° mo le tusa ma le 15 min.
Tulaga talia: So'o se vaega lona lua o le Fa'ata'ita'iga fofo e le sili atu pe sili atu le malosi nai lo le vaega autu o le Fofo Fa'ata'atia1, se'i vagana ai le vaega e fetaui ma le tyrosine, e le tele pe sili atu le malosi nai lo le nofoaga autu mai le vaifofo masani 2.
Fa'aletagata ta'ito'atasi: NMT 0.5%
Tapula'a ole tyrosine: NMT 1.0%
SU'E FA'AMANATU
FAAMAGO LOTO <731>: Fa'amago se fa'ata'ita'iga ile 105 ℃ mo le 3 itula: e to'esea NMT 0.1% o lona mamafa.
FAAOPOOPOGA
FA'A'U'U MA TE'UINA: Fa'asa'o i pusa tapuni lelei, ma teu i le vevela o le potu.
USP REFERENCE STANDARD <11>
USP N-Acetyl-L-tyrosine RS
USP L-Tyrosine RS
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Galuega & Fa'aoga ole N-Acetyl-L-Tyrosine (Ac-Tyr-OH; NALT) (CAS: 537-55-3) paʻu
1. N-Acetyl-L-Tyrosine o se acetyl derivative o le amino acid, L-tyrosine.E solu fua ile vai fa'atusatusa ile L-tyrosine ma e masani ona fa'aogaina e fai ma fa'aopoopoga o mea'ai a matua.N-Acetyl-L-Tyrosine , o se faʻamautu ma sili atu ona soluble ituaiga o tyrosine, ua faʻapipiʻiina i nisi o loʻo avanoa nei faʻatau pisinisi faʻamalama amino acid e pei o TrophAmine ma Aminosyn-II.
2. N-Acetyl-L-Tyrosine o loʻo aʻafia i le gaosiga o catecholamine.E mafai ona faʻaaogaina e avea o se vaega faʻasalalau aganuʻu aganuʻu i le biomanufacture faapisinisi o polotini recombinant togafitiga ma antibodies monoclonal.
3. N-Acetyl-L-Tyrosine o se amino acids taua, o se ituaiga o meaʻai taua mo le metabolism o le tagata ma manu, tuputupu aʻe ma le atinaʻe e taua tele, e mafai ona faʻaaogaina lautele i meaʻai, vailaʻau ma isi.
4. O le N-Acetyl-L-Tyrosine e iai sona sao taua i le tu'ufa'atasiga o le dopamine ma isi hormones i lou tino.E mafai ona faʻaleleia le maualuga o le neurotransmitters dopamine, norepinephrine ma epinephrine.E fesoasoani e lagolago ai tulaga maualuga o le taula'i ma galuega fa'atino.E mafai ona fa'ateleina le manatua o galuega ma lagona o le soifua manuia.
5. N-Acetyl-L-Tyrosine ua suia mai le Tyrosine masani ona o loʻo i ai le faʻaopoopoga o le acetic acid.E fesoasoani moni lava lea i le fa'atuputeleina o le bioavailability o le vaila'au ina ia sili atu ona mitiia sa'o i totonu o le toto.
6. O le N-Acetyl-L-Tyrosine o se ituaiga sili ona olaola o le L-Tyrosine mo le togafitiga masani o lagona maualalo N-Acetyl-L-Tyrosine e mafai ona fa'aogaina i tui maualalo nai lo le L-Tyrosine.O le L-Tyrosine masani e itiiti le mautu ma e le mafai ona faʻafefe i le vai, lea e ono faʻaititia ai le bioavailability.
7. O le N-Acetyl-L-Tyrosine e faʻaleleia ai le solubility ma le mautu ma avea ai ma se ituaiga sili atu ona vave faʻafefe ma bioavailable o le amino acid L-Tyrosine lea e faʻaitiitia ai le faʻaogaina o le urinary excretion.
