N(4)-Hydroxycytidine CAS 3258-02-4 EIDD-1931 NHC Tulaga Maualuga
Tuuina atu ma le mama maualuga ma le mautu lelei
Igoa Vailaau: N(4)-Hydroxycytidine;EIDD-1931 (NHC)
CAS: 3258-02-4
O se metabolite malosi o le Molnupiravir, o se fa'ailo mautinoa ole COVID-19
| Igoa Vailaau | N(4)-Hydroxycytidine |
| Synonyms | EIDD-1931 (NHC);β-D-N4-Hydroxycytidine |
| Numera CAS | 3258-02-4 |
| CAT Numera | RF-PI309 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o I Kilograms |
| Fuafua mole | C9H13N3O6 |
| Molecular Weight | 259.22 |
| Lisi Lisi | 169.0~172.0 ℃ |
| Solubility | Solu i le 100 mM ile DMSO ma le 50 mM ile Vai |
| Malosi | 1.93±0.1 g/cm3 |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e |
| NMR | O gatasi ma le Fauga |
| Mama / Suʻesuʻega Metotia | >98% (HPLC) |
| Ma'imau ile Fa'amago | ≤1.0% |
| Le mama nofofua | ≤0.50% |
| Metala mamafa | ≤20ppm |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | O se metabolite malosi o le Molnupiravir (EIDD-2801), o se fa'aitaga COVID-19 |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
N(4)-Hydroxycytidine (EIDD-1931 , β-d-N4-hydroxycytidine, NHC, CAS 3258-02-4) o se metabolite malosi o le EIDD-2801, o se fa'ailo fa'amaonia COVID-19.EIDD-1931 (NHC) o loʻo i ai le tele o alaleo faʻamaʻi faʻamaʻi e faasaga i le tele o coronavirus, e aofia ai le SARS-CoV-2, MERS-CoV, SARS-CoV, ma vaega zoonotic 2b poʻo le 2c Bat-CoVs faʻatasi ma le averesi IC50 o le 0.15 μM, faʻapea foʻi ma fa'atuputeleina le malosi e tetee atu ai i le coronavirus o lo'o fa'atupu suiga i le nucleoside analog inhibitor remdesivir.I isumu ua pisia i le SARS-CoV poʻo le MERS-CoV, faʻataʻitaʻiga ma togafitiga faʻapitoa ole Molnupiravir (EIDD-2801), ole NHC-prodrug (β-D-N4-hydroxycytidine-5'-isopropyl ester), faʻaleleia le gaogao mama. , ma fa'aititia le titer virus ma le pa'u mamafa o le tino.Fa'aititia MERS-CoV fua in vitro ma in vivo sa feso'ota'i ma le fa'ateleina o suiga o suiga i le viral ae le o le host cell RNA, e lagolagoina ai se faiga o mutagenesis oti i le CoV.Ole malosi ole NHC/EIDD-2801 e tetee atu ai i le tele o coronavirus ma le fa'aogaina o le gutu o lo'o fa'amamafaina ai lona aoga aoga e avea o se antiviral aoga e tetee atu ai i le SARS-CoV-2 ma isi coronavirus zoonotic i le lumana'i.
