Olmesartan Medoxomil CAS 144689-63-4 Mama >99.5% (HPLC) API Falegaosi
Ruifu Sapalai Vailaau Matagofie Olmesartan Medoxomil Intermediates Ma Tulaga Maualuga:
4,5-Dimethyl-1,3-Dioxol-2-One (DMDO) CAS 37830-90-3
4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One (DMDO-Cl) CAS 80841-78-7
Ethyl 4-(1-Hydroxy-1-Methylethyl)-2-Propyl-Imidazole-5-Carboxylate CAS 144689-93-0
Diethyl 2-Propyl-1H-Imidazole-4,5-Dicarboxylate CAS 144689-94-1
Trityl Olmesartan Ethyl Ester CAS 144690-33-5
Trityl Olmesartan Acid CAS 761404-85-7
N2-Trityl Olmesartan Acid CAS 752179-89-8
Trityl Olmesartan Medoxomil CAS 144690-92-6
Olmesartan Medoxomil CAS 144689-63-4
Igoa Vailaau | Olmesartan Medoxomil |
Synonyms | 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H- imidazole-5-carboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester;CS-866 |
Numera CAS | 144689-63-4 |
CAT Numera | RF-PI1730 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
Fuafua mole | C29H30N6O6 |
Molecular Weight | 558.60 |
Lisi Lisi | 180℃ (Tes.) |
Suavai Solubility | E le mafai ona solu i le Vai;Laititi solu i le DMSO |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'epa'e i le Toeitiiti Pa'epa'e Cyrstalline Pa'u |
Fa'ailoaga | IR, HPLC, UV: E tatau ona ogatasi ma Fa'amaumauga Fa'asinomaga |
Mama / Suʻesuʻega Metotia | >99.5% (HPLC i luga o le Anhydrous ma Solvent-Free Basis) |
Ma'imau ile Fa'amago | <0.50% |
Toega i luga o le mumu | <0.10% |
Mea Fa'atatau | |
Olmesartan RRT 0.2 | <0.50% |
Olmesartan Medoxoil Fa'atatau A. RRT 0.7 | <0.20% |
Olefinic le mama RRT 1.6 | <0.50% |
N-Alkyl Le mama RRT 3.4 | <0.10% |
So'o se isi mea le mama | <0.10% |
Aofa'i Fa'aleaga | <0.50% |
Metala mamafa (pei o le Pb) | <10ppm |
pH o Fofo (2%, W/V) | 4.5 i le 6.5 |
Tulaga Su'ega | Atina'e Atina'e;USP Standard |
Fa'aoga | API |
afifi: Fagu, ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu
Olmesartan Medoxomil (CS-866) (CAS: 144689-63-4) o se angiotensin II ituaiga 1 (AT(1)) mamana ma le filifilia o le tali faʻafeagai ma le IC50 o le 66.2 μM., faʻaaogaina i le togafitiga o le toto maualuga.Fa'aaogaina e fai ma anti-hypertensive.O le Olmesartan e galue e ala i le polokaina o le fusifusia o le angiotensin II i le AT1 receptors i maso vascular.E ala i le polokaina o le fusifusia nai lo le tuʻufaʻatasia o le angiotensin II, Olmesartan faʻalavelaveina le le lelei o faʻatonuga faʻatonutonu ile faʻaogaina o le renin.Olmesartan Medoxomil ose vailaʻau faʻamalosi lea e faʻamalo i le metabolite malosi, olmesartan.Olmesartan Medoxomil na faʻalauiloaina i le US e pei o Benicar, o se togafitiga tuʻu gutu mo le toto maualuga.