Pirfenidone CAS 53179-13-8 Mama ≥99.0% IPF
Tuuina atu ma le mama maualuga, gaosiga faapisinisi
Igoa Vailaau: Pirfenidone
CAS: 53179-13-8
| Igoa Vailaau | Pirfenidone |
| Synonyms | Perfenidone;5-Methyl-1-Phenylpyridine-2(1H)-tasi;PFD;S-7701;AMR-69 |
| Numera CAS | 53179-13-8 |
| CAT Numera | RF-API108 |
| Tulaga Fa'asoa | E tele |
| Fuafua mole | C12H11NO |
| Molecular Weight | 185.22 |
| Lisi Lisi | 96.0 i le 97.0 ℃ |
| Solubility | Solu i le DMSO |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e i le Malamalama Samasama Crystalline Powder |
| Fa'ailoaga | IR |
| Mama | ≥99.0% |
| Ma'imau ile Fa'amago | ≤0.50% |
| Lefulefu Sulfated | ≤0.20% |
| Le mama nofofua | ≤0.50% |
| Aofa'i Fa'aleaga | ≤1.0% |
| Metala mamafa | ≤20ppm |
| Tulaga Su'ega | Enterprise Standard |
| Fa'aoga | API, Idiopathic Pulmonary Fibrosis (IPF) |
afifi: Fagu, taga pepa alumini, 25kg / Cardboard Drum, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu.
Pirfenidone (CAS: 53179-13-8) o loʻo i totonu o se vaega o vailaʻau e taʻua o le antifibrotic agents.Pirfenidone ua faʻaalia le gaioiga i le tele o fibrotic tulaga, e aofia ai le mama, fatugaʻo ma le ate.E a'afia ai le puipuiga o lou tino ma fa'aitiitia ai le fibrosis (ma'ila) ile māmā.Pirfenidone o se tasi o vailaʻau e lua ua faʻamaonia i Kanata e togafitia ai le Idiopathic Pulmonary Fibrosis (IPF).Pirfenidone o se inhibitor mo le gaosiga o le TGF-β ma le TGF-β faʻaosofia le gaosiga o le collagen, faʻaitiitia le gaosiga o le TNF-α ma le IL-1β, ma e iai foʻi mea faʻamaʻi-fibrotic ma anti-inflammatory.Na faʻamaonia muamua i Iapani mo togafitiga o tagata mamaʻi i le idiopathic pulmonary fibrosis ina ua maeʻa faʻataʻitaʻiga falemaʻi, i lalo o le igoa tau fefaʻatauaʻiga o Pirespa e Shionogi, i le 2008. Na faʻamaonia mo le faʻaaogaina i le Europa Europa i le 2011, i Kanata i le 2012, ma i totonu. Amerika ia Oketopa 2014.
