Polymyxin B Sulfate CAS 1405-20-5 Su'ega Microbiological ≥6500 IU/mg Falegaosimea
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua ma le tuʻuina atu o le Polymyxin B Sulfate (CAS: 1405-20-5) faʻatasi ai ma le maualuga.E mafai ona matou tuʻuina atu COA, faʻasalalauga i le lalolagi atoa, laʻititi ma le tele o loʻo avanoa.Afai e te fiafia i le Polymyxin B Sulfate,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | Polymyxin B Sulfate |
| Synonyms | Polymyxin B Sulfate Salt;Aerosporin;Mastimyxin;PXNS;PMB;Poly-RX |
| Tulaga Fa'asoa | I Fa'atauga, Gaosi Gaosi 10 Tone i le Tausaga |
| Numera CAS | 1405-20-5 |
| Fuafua mole | C55H96N16O13·2H2SO4 |
| Molecular Weight | 1301.56 |
| Lisi Lisi | 217.0~220.0℃(Tes.) |
| Ma'ale'ale | Hygroscopic.Ma'ale'ale ile Malamalama ma le Vevela |
| Suavai Solubility | Solu i le Vai, 50 mg/mL.Laititi Solu i le Ethanol |
| COA & MSDS | Avanoa |
| Fa'ata'ita'iga | Avanoa |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga | I'uga |
| Fa'aaliga | Pa'epa'e po'o Toeitiiti fa'atasi ma le pauta tioata | Fa'atatau |
| Fa'ailoaga A. O taimi fa'amauina o tumutumu tetele mai le fa'ata'ita'iga fa'ata'ita'iga e fetaui ma taimi o le vaifofo masani, e pei ona maua i le su'ega mo le tu'ufa'atasiga o Polymyxins. | Fa'atatau | |
| PH (2%) | 5.0~7.0 | 5.7 |
| PH (0.5%) | 5.0~7.5 | 5.5 |
| Sulphated Ash | ≤0.75% |
|
| Ta'amilosaga Fa'apitoa [α]20/D | -78.0°~-90.0°(C=2, H2O) (Ccalcd. on Anh. Substance) | -85.0° |
| Sulphate | 15.5~17.5% | 16.65% |
| Ma'imau ile Fa'amago | ≤6.00% | 3.0% |
| Toega i luga o le mumu | ≤0.10% | 0.02% |
| Metala mamafa | ≤20ppm | ≤20ppm |
| Phenylalanine | 9.0~12.0% | 9.8% |
| Aofa'i Viabel Aerobic Count | ≤10cfu/g | ≤10cfu/g |
| Mea Fa'atatau, HPLC |
|
|
| Le mama o le tagata lava ia | ≤3.0% | 2.723% |
| Aofa'i Fa'aleaga | ≤17.0% | 16.223% |
| Su'ega HPLC (ODB) | Aofa'iga o Polymyxins B1,B2,B3 ma le B1-1: ≥80.0% | 86.6% |
| Polymyxin B3: ≤ 6.0% | 3.8% | |
| Polymyxin B1-1: ≤15.0% | 8.5% | |
| Su'ega, Microbiological (pei) | ≥6500lU/mg | 8255IU/mg |
| Lapo'a La'au | ≥99.0% ≤30um e vol | Fa'atatau |
| ≥90.0% ≤25um e vol | ||
| ≥75.0%≤20um e vol | ||
| ≥35.0%≤10um e vol | ||
| Fa'ai'uga | O le oloa e ogatasi ma le USP42 |
|
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Tulaga teuina:Ma'ale'ale malamalama.Taofi mau le atigipusa ma teu i totonu o se faleteuoloa malulu, mago (2~8 ℃) ma fa'alelei lelei mai mea e le fetaui.Puipui mai le malamalama ma le susu.E le fetaui ma vailaʻau faʻamaʻi malosi.
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Fa'ailoga Mata'utia Xn - Fa'aleagaina
Fa'ailoga Tulaga 22 - E afaina pe a folo
Fa'amatalaga Saogalemu S22 - Aua le manava pefu.
S24/25 - Aloese mai le pa'i i le pa'u ma mata.
UN IDs 3249
WGK Siamani 3
RTECS TR1150000
FLUKA BRAND F CODES 3-8-10
HS Code 2941909099
Vasega o Tulaga Lamatia 6.1(b)
Vaega fa'aputu III
O le Polymyxin o se vaega o vailaʻau polypeptide na gaosia e le Bacillus polymyxa (bacilluspolymyxa).O le Polymyxin B ma le E o loʻo faʻaaogaina mo togafitiga faafomaʻi, ma o latou sulfate e masani ona faʻaaogaina.Ole alaleo antibacterial ma le faʻaogaina ole falemaʻi ole Polymyxin B Sulfate e tutusa ma le polymyxin E. E iai aʻafiaga faʻafefe poʻo faʻamaʻi i luga o le gram-negative bacilli, e pei ole Escherichia coli, Pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, pertussis ma Shigella.
O le Polymyxin Sulfate B e tutusa ma le polymyxin e, ma e iai a'afiaga fa'alavelave po'o fa'ama'i fa'ama'i i bacilli gram-negative, pei ole u.coli, pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, bacilli pertussis ma le dysentery bacilli.E masani ona faʻaaogaina i le manuʻa, urinary tract, mata, taliga, trachea ma isi vaega o faʻamaʻi pipisi e mafua mai i le Pseudomonas aeruginosa ma isi Pseudomonas.E mafai foi ona faʻaaogaina mo sepsis ma peritonitis.Ma faʻamaʻi pipisi e mafua mai i aminoglycosides, siama faʻamaʻi cephalosporin lona tolu, Pseudomonas aeruginosa poʻo isi siama maʻaleʻale, e pei o le bacteremia, endocarditis, niumonia, faʻamaʻi pipisi, ma isi.
1. Intravenous drip: tagata matutua ma tamaiti o loʻo i ai le gaioiga masani o le fatu 1.5 ~ 2.5mg i le kilokalama o le mamafa o le tino (masani e le sili atu i le 2.5mg i le kilokalama o le mamafa o le tino) mo le 1 aso, vaevaeina i le 2 taimi, faʻafefe tasi i le 12 itula.O 50mg uma o lenei oloa e fa'afefeteina i le 500ml ole 5% o le kulukose solution ona fa'asusu lea.O pepe e iai le gaogao masani e mafai ona talia le 4mg i le kilokalama o le mamafa o le tino mo le aso e tasi.2. Intramuscular tui: tagata matutua ma tamaiti: 2.5 ~ 3mg i le kilokalama o le mamafa o le tino i le 1st, tuʻuina atu i vaega, tasi i le 4 ~ 6 itula.O pepe e mafai ona o'o i le 4mg i le kilokalama o le mamafa o le tino i le aso ma pepe fou e mafai ona o'o i le 4.5mg i le kilokalama o le mamafa o le tino.3. Tuiina i totonu (mo le maningitis Pseudomonas aeruginosa): 5mg i le mililita o vailaʻau faʻasaina ua saunia ile tui ole sodium chloride.Tagata matutua ma tamaiti e sili atu i le 2 tausaga, 5mg i aso uma, pe a maeʻa le 3-4 aso o le faʻaaogaina, sui i le tasi aso i isi aso, ia le itiiti ifo i le 2 vaiaso, seia oʻo ina leaga le aganuʻu o le cerebrospinal fluid, ma o le suka e masani lava.Mo tamaiti i lalo ifo o le 2 tausaga, faʻaaoga le 2mg tasi i le aso mo le 3-4 aso sosoo (poʻo le 2.5mg tasi i isi aso), ona faʻaaoga lea o le 2.5mg tasi i isi aso seia oʻo ina masani le suʻega.4. O le faʻaogaina o mataʻu mata o le 1 ~ 2.5mg i le ml.
Aloese mai le tu'ufa'atasia ma vaila'au e fa'aleagaina ai fatuga'o, fa'amama maso o le skeletal, vaila'au aminoglycoside, fa'ama'i fa'ama'i e fa'amanino a'afiaga maso (e pei o le enflurane), ma isi, ma le quinine, magnesium, ma isi.O le Polymyxin B sulfate e tuʻufaʻatasia ma sulfonamides, rifampicin, semi-synthetic penicillin, ma isi, mo le togafitia o faʻamaʻi pipisi o le gram-negative faʻamaʻi, ma o le aʻafiaga e sili atu nai lo le faʻaaogaina e tasi.
1, O fafine maʻitaga ma lactating, tamaiti, ma tagata mamaʻi o loʻo i ai le faaletonu o le tino e sili atu ona taatele.2. O lenei oloa e sili ona oona ma e le lelei le togafitiga i faʻamaʻi pipisi loloto.E le o se filifiliga muamua mo soʻo se faʻamaʻi.3. O tui fa'atoto e ono mafua ai le manava manava, lea e masani ona le fa'aaogaina.E le itiiti ifo ma le afa o le fua o aso ta'itasi e mana'omia ai le fa'amama toto, ae le o se bolus vave i le taimi e tasi, ina ia aloese mai le tele o poloka neuromuscular.4. E le tatau ona tuʻufaʻatasia ma isi vailaʻau e iai le nephrotoxicity poʻo le neuromuscular blockade e aloese ai mai faʻalavelave.
Su'esu'ega biochemical.O le Polymyxin B o se anti-gram-negative bacilli polypeptide antibiotic, lea e mafai ona suia le fausaga o le membrane e tafe ai ni molelaʻi laiti ma taofia ai le tuputupu aʻe o siama gram-negative.E iai sona aafiaga fa'ama'i ile Escherichia coli.Lipid A vaega e fusifusia i lipopolysaccharides siama.O pores laiti o lo'o fa'aosoina i totonu ole pa'u pa'u pito i fafo.Faiga o gaioiga: fusifusia ma faʻalavelave i le faʻaogaina o le membrane cytoplasmic.Alaleo fa'ama'i: siama kalama e leaga.
Polymyxin B, Sulfate.
Polymyxin B Sulfate [1405-20-5].
» Polymyxin B Sulfate o le masima sulfate o se ituaiga polymyxin, o se mea e gaosia e le tuputupu aʻe o le Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae), poʻo se faʻafefiloi o lua pe sili atu masima faapena.E iai lona malosi e le itiiti ifo i le 6000 Polymyxin B Units i mg, fa'atatau ile fa'amamago.
Fa'apipi'i ma teu-fa'asa'o i totonu o koneteina fufusi ma mama.
Fa'ailoga - Pe a fa'apipi'iina mo le fa'apipi'iina o talavai, o lo'o ta'u mai e le igoa le numera o Polymyxin B Units i totonu o le atigipusa ma le milligram, e le'o fa'amoemoe mo le fa'aogaina o le gaosiga, e le o fa'amama, ma e le mafai ona mautinoa lona malosi mo le umi atu i le 60. aso talu ona tatala.Afai e fa'amoemoe mo le fa'aogaina i le sauniaina o tui tui po'o isi vaila'au tu'umama, o lo'o ta'u mai e le fa'ailoga e fa'amama pe tatau fo'i ona toe fa'agaoioiga i le taimi o le tapenaga ole tui po'o isi vaila'au tu'umama.
USP Reference standards <11>-
USP Polymyxin B Sulfate RS
Fa'ailoa-
A: Su'e Su'e Chromatographic Identification Su'ega-
Vaega feavea'i-Sauni se paluga ole 0.1 M tribasic sodium phosphate ma acetonitrile (77:23), ma fetuutuunai ma le phosphoric acid ile pH ole 3.0.Fai ni fetuunaiga pe a mana'omia (silasila i le System Suitability i lalo ole Chromatography <621>.
Fofo masani-Sauni se vaifofo o le USP Polymyxin B Sulfate RS i le vaega feavea'i e iai le fa'atonuga e tusa ma le 3.5 mg i le mL.Puipui lenei fofo mai le malamalama.
Fofo o le su'ega-Sauni se vaifofo o le Polymyxin B Sulfate ile vaega feavea'i e iai lona fa'atonuga e tusa ma le 3.5 mg i le mL.Puipui lenei fofo mai le malamalama.
Chromatographic system (silasila Chromatography <621>)-O le chromatograph vai ua fa'apipi'iina i le 212-nm detector ma le 4.6-mm × 25-cm koluma e iai le 5-µm fa'apipi'i L1.Ole fua ole tafe e tusa ma le 1 mL ile minute.
Faiga-Tu'i ese voluma tutusa (pe tusa ma le 10 µL) o le vaifofo masani ma le vaifofo o le Su'ega i totonu o le chromatograph, ma faamaumau ia chromatograms.O le chromatogram na maua mai le Su'ega fofo e fetaui lelei ma le mea na maua mai i le vaifofo Fa'ata'atia, fa'aalia se tumutumu tele e tutusa ma le polymyxin B1 ma tumutumu i taimi fa'atumauina e tusa ma le 0.5 (polymyxin B2) ma le 0.6 (polymyxin B3).
B: Fa'amuta le 2 mg i le 5 mL o le vai, fa'aopopo le 5 mL o le 2.5 N sodium hydroxide, fa'afefiloi, ma fa'aopoopo i ai le 5 mataua o le solution cupric sulfate (1 i le 100), lulu pe a uma le fa'aopoopoina o mataua ta'itasi: e maua ai se lanu mūmū violē. .
C: O se fofo (1 i le 20) e fetaui ma manaʻoga o suʻega mo Sulfate <191>.
pH <791>: i le va o le 5.0 ma le 7.5, i se vaifofo e iai le 5 mg i le mL.
Ma'imau ile fa'amago <731>-Fa'amago e tusa ma le 100 mg, sa'o le fuaina, i totonu o se fagu fa'apipi'i-capillary i le vacuum i le 60 ℃ mo le 3 itula: e le sili atu i le 7.0% o lona mamafa.
Anotusi o le phenylalanine-Transfer e tusa ma le 0.375 g o le Polymyxin B Sulfate, fuaina sa'o, i se fagu volumetric 100-mL, fa'amavae i totonu ma fa'afefete i le 0.1 N hydrochloric acid i le voluma, ma fa'afefiloi.Fua le absorbances o lenei fofo i le maxima e uiga i le 264 nm (A264), 258 nm (A258), ma le 252 nm (A252), ma absorbances i le 280 nm (A280) ma le 300 nm (A300).Fa'atatau le pasene ole phenylalanine ile vaega ole Polymyxin B Sulfate na ave ile fua fa'atatau:
(9.4787/W)(A258 – 0.5A252 + 0.5A264 – 1.84A280 + 0.8A300)
o le W o le mamafa, i le g, o le Polymyxin B Sulfate na ave: o loʻo i ai i le va o le 9% ma le 12% o le phenylalanine, fuafua i luga o le faʻamago.
O isi mana'oga - Afai mo le fa'apipi'iina o talavai, o lo'o fa'amalieina mana'oga mo Toega i le fa'amumu i lalo ole Polymyxin B mo le tui.Afai o lo'o ta'ua i le fa'ailoga o le Polymyxin B Sulfate e fa'amama, e fetaui ma mana'oga mo Su'ega Fa'amama <71> ma, pe a fa'amoemoeina mo fa'ainu tui, mo le Pyrogen i lalo ole Polymyxin B mo tui.Afai o loʻo taʻu mai e le igoa o le Polymyxin B Sulfate e tatau ona faʻaogaina atili i le taimi o le sauniuniga o faʻasologa o vailaʻau, e fetaui ma manaʻoga mo Pyrogen i lalo ole Polymyxin B mo tui.
Su'ega-Fa'agasolo ile Polymyxin B Sulfate e pei ona fa'atonu i lalo ole Antibiotics-Microbial Assays <81>.
