Posaconazole CAS 171228-49-2 API Falegaosi Triazole Antifungal Agent Maualuga Maualuga
Sapalai Falegaosi Posaconazole Fesoʻotaʻiga Vaavaʻa, Gaosiga Faʻapisinisi
Posaconazole CAS 171228-49-2
Posaconazole Intermediate POA CAS 149809-43-8
Phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate CAS 184177-81-9
1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine CAS 74853-08-0
2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxal CAS 170985-85-0
Diethyl L-(+)-Tartrate CAS 87-91-2
Igoa Vailaau | Posaconazole |
Synonyms | POS;SCH 56592;4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl] methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one |
Numera CAS | 171228-49-2 |
CAT Numera | RF-API77 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
Fuafua mole | C37H42F2N8O4 |
Molecular Weight | 700.78 |
Malosi | 1.36 g/cm3 |
Solubility | Solu i le DMSO, le mafai ona solu i le vai |
Tulaga Va'a | La'uina i lalo ole vevela ole ambient |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'epa'e i le Pa'u Pa'epa'e Pa'epa'e |
Faailoaina A | IR: Ole alaleo ole absorption infrared o le oloa e tatau ona ogatasi ma le mea o lo'o fa'asino i ai |
Faailoaga B | HPLC Taimi fa'atumauina tutusa ma mea fa'asino |
Lisi Lisi | 167.0~171.0 ℃ |
Ta'amilosaga Fa'apitoa [a]20 | -24.0° ~ -28.0° (C=1, CHCL3) |
Vai (KF) | ≤1.0% |
Toega i luga o le mumu | ≤0.10% |
Mea Fa'atatau | |
HT 909-24 | ≤0.20% |
So'o se Fa'aleaga Ta'ito'atasi | ≤0.10% |
Aofa'i Fa'aleaga | ≤1.0% |
Solvents totoe | |
Methanol | ≤3000ppm |
Methyl tert-Butyl Eteru | ≤5000ppm |
Isopropanol | ≤5000ppm |
Dimethyl Sulfoxide | ≤5000ppm |
Dichloromethane | ≤600ppm |
Su'ega | 98.0%~102.0% (Fa'atatau ile fa'amamago) |
Metala mamafa | ≤10ppm |
Isomer | Enantiomer ≤0.10% |
So'o se tagata le mama ≤0.10% | |
Aofa'i Fa'aleaga ≤1.0% | |
Tulaga Su'ega | Atina'e Atina'e;USP;BP;EP Tulaga |
Fa'aoga | API, Triazole Antifungal Agent |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Posaconazole (CAS 171228-49-2), o le lautele o alaleo, lona lua o augatupulaga, triazole faʻatasi ma le antifungal gaioiga, faʻalauiloaina i Peretania, o le sui fou o le azole vasega o vailaʻau faʻamaʻi e oʻo atu i le maketi.O lo'o fa'ailoa mai mo le togafitia ma le puipuia o le tele o fa'ama'i pipisi, e aofia ai le aspergillosis, fusariosis, chromoblastomycosis, mycetoma, ma le coccidiomycosis i tagata mama'i e le mafai, po'o le le fa'apalepale, togafitiga masani ma amphotericin B ma/po'o itraconazole.I totonu o le US, ua fa'atagaina mo le puipuia o fa'ama'i pipisi o Aspergillus ma Candida i tagata mama'i e 13 tausaga le matutua o lo'o i ai i le maualuga o le lamatiaga o le atia'e o nei fa'ama'i ona o le matua'i fa'aletonu.E le gata i lea, ua faʻamaonia mo togafitiga o candidiasis oropharyngeal.Posaconazole o loʻo i ai le faʻalauteleina o alaleo o gaioiga i luga o isi sui o le azole antifungals.I le faʻaopoopoga i gaioiga malosi e faasaga i mataupu faʻafefe o le aspergillosis ma le fluconazole-resistant Candida, e faʻaalia ai le gaioiga faasaga i Zygomycetes.Posaconazole o se vailaʻau faʻamaʻi triazole faʻatau atu i le Iunaite Setete e Schering-Plough i lalo o le igoa tau fefaʻatauaʻiga Noxafil.