Pregabalin CAS 148553-50-8 Mama >99.0% (HPLC) Antiepileptic API
Gaosi mea e maua ai le mama maualuga ma le gaosiga o pisinisi
Igoa Vailaau: PregabalinCAS: 148553-50-8
O le Pregabalin o se vailaʻau faʻamaʻi faʻamaʻi faʻamaʻi lona lua (AED)
Igoa Vailaau | Pregabalin |
Synonyms | (S)-3-(Aminomethyl)-5-Methylhexanoic Acid;PD-144723;PD144723;CI 1008;CI-1008;Lyrica |
Numera CAS | 148553-50-8 |
CAT Numera | RF-API57 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
Fuafua mole | C8H17NO2 |
Molecular Weight | 159.23 |
Lisi Lisi | 194.0~196.0 ℃ |
Solubility i le Vai | E le mafai ona solu i le Vai |
Solubility | E matua solu i le Ethanol |
Tulaga Va'a | I lalo ole Temperature Ambient |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'epa'e i le Pa'u Pa'epa'e Pa'epa'e |
Fa'ailoaga | IR: E tutusa ma Reference Substance |
Ta'amilosaga Fa'apitoa | +10.0°~+13.0° (C=1, Vai) |
Ma'imau ile Fa'amago | <0.50% |
Sulphated Ash | <0.10% |
Mea Fa'atatau | Le mama A <0.15% |
Fa'amama le fa'ailoaina o lo'o fa'amama i luma o le Pregabalin (su'ega A) <0.10% | |
Le fa'amamafaina le fa'amama fa'amama fa'amama i le mae'a o le Pregabalin (su'ega B ) <0.10% | |
Aofa'i mo su'ega A ma le B <0.50% | |
Mamaa Saunia e HPLC R-Isomer | <0.15% |
Metala mamafa (pei o le Pb) | <10ppm |
Klorida (Cl) | <0.05% |
Solvents totoe | |
Isopropyl Alcohol | <5000ppm |
Ethyl Acetate | <5000ppm |
Tetrahydrofuran | <250ppm |
Isopropyl Eteru | <500ppm |
Ethanol | <1000ppm |
Mama / Suʻesuʻega Metotia | >99.0% (HPLC ile fa'amamago) |
Tulaga Su'ega | Pisinisi Tulaga |
Fa'aoga | Antiepileptic Drug API |
afifi: Fagu, ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu
O le Pregabalin o se vailaʻau faʻamaʻi faʻamaʻi lona lua (AED) ua lauiloa i le igoa faʻapitoa o Lyrica (Pfizer, Tadworth) i Peretania ma ISA, o loʻo i ai se fausaga γ-amino butyric acid i luga o lona fausaga mole, lea e iai aʻafiaga faʻafefe, ma e manuia le atinaʻeina e le kamupani Pfizer mo le togafitia o tiga o le neuropathic peripheral, poʻo le togafitiga faʻapitoa o vaega faoa faamalosi.Pregabalin o se Anticonvulsant ma antiepileptic vailaʻau faʻaaogaina e togafitia ai le epilepsy, tiga o le neuropathic, fibromyalgia, ma le faʻalavelave popole lautele.O lona fa'aogaina mo le ma'i epilepsy o se fa'aopoopoga o togafitiga mo vaega faoa faoa fa'atasi ma pe leai fo'i se fa'asalalauga lona lua i tagata matutua.Ia Tesema 2008, na faʻamaonia ai e le US Food and Drug Administration (FDA) le pregabalin (igoa fefaʻatauaʻiga "Lyrica") mo le togafitia o tiga o le neuropathic peripheral (DPN) ma le postherpetic neuralgia (PHN) ia e lua e sili ona taatele tiga neuropathic.O le Pregabalin o loʻo i ai se faʻamaoniga faʻamaonia ma e faʻaaogaina lautele mo togafitiga o le faʻalavelave popole lautele.O nisi o su'esu'ega fa'afuase'i, tauaso lua, placebocontrolled na maua ai o le pregabalin ose togafitiga lelei mo tagata mama'i e le atoatoa le popole ma le fa'aletonu o popolega lautele.Fuafuaga titration Epilepsy-fa'aopoopo togafitiga: 25 mg bd mo le 7 aso, e fa'aopoopo i le 50 mg i aso ta'i 7;tausiga masani 300 mg i aso uma, vaevaeina i 2 poʻo 3 doses (max. 600 mg i aso uma, vaevaeina i 2 poʻo 3 doses).Fa'aletonu popolega lautele: 150 mg i aso uma, vaevaeina i 2 poʻo 3 tui, mo le 7 aso, e faʻateleina i le 150 mg i aso uma 7 (max. 600 mg i aso uma, vaevaeina i 2 poʻo 3 doses).Afai e taofi le pregabalin, e fautuaina e faʻapipiʻi a itiiti ifo ma le 1 le vaiaso e aloese ai mai le faʻafuaseʻi ona aveese.Lapata'iga O ma'i ei ai tulaga e ono fa'atupu ai le encephalopathy.O ma'i e ogaoga le faaletonu o le fatu.