(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Mama ≥99.7% (GC) Chiral Purity ≥99.7% Panipenem ma Darifenacin hydrobromide Intermediate
Sapalai a le Kamupani;Mamaa maualuga ma Tau Faatauva
Shanghai Ruifu Chemical Co., Ltd. Sapalai Fefa'ataua'iga Chiral Compounds:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S)-3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Intermediate o Panipenem (CAS 87726-17-8) ma Darifenacin hydrobromide (CAS 133099-07-7)
| Igoa Vailaau | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| Synonyms | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| Numera CAS | 104706-47-0 |
| CAT Numera | RF-CC102 |
| Mama / Suʻesuʻega Metotia | ≥98.0% (GC) |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
| Fuafua mole | C4H10ClNO |
| Molecular Weight | 123.58 |
| Lisi Lisi | 107.0 ~ 111.0 °C |
| Solubility i le Vai | Toeititi lava Malamalama |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e-Pa'epa'e e'e enaena enaena pauta tioata |
| Mama / Suʻesuʻega Metotia | ≥99.7% (GC) |
| Chiral Mama | ≥99.7% ee |
| Toega i luga o le mumu | ≤0.50% |
| Ta'amilosaga Fa'apitoa [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| So'o se Fa'aleaga Ta'ito'atasi | ≤0.20% |
| Aofa'i le mama | ≤0.30% |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | Vailaau Fa'atekonolosi;Chiral Compounds |
Metotia Su'esu'ega
Mea faigaluega: GC meafaigaluega (Shimadzu GC-2010)
Koluma: DB-17 Agilent 30mX0.53mmX1.0μm
O le vevela o le ogaumu muamua: 80℃
Taimi muamua 2.0min
Fua 15℃/min
O le vevela o le ogaumu mulimuli: 250℃
Taimi mulimuli 20min
Kasa e ave ai le Nitrogen
Faiga Fa'asolo pea
tafe 5.0mL/min
Vaevae fua 10:1
Injector vevela: 250 ℃
Su'e vevela: 300℃
Volume tui 1.0μL
Lapataiga e tatau ona faia a'o le'i su'esu'eina:
1. Tu'u le koluma ile 240℃ mo le la'ititi ole 30minute.
2. Fufulu sa'o le tui ma fa'amama injector liner e aveese ai mea leaga o le su'esu'ega muamua.
3. Fufulu, fa'agogo ma fa'atumu le vai fa'afefiloi i fagu fufulu tui.
Sauniuniga vaiinu:
Saunia 2% w/v sodium hydroxide solution ile vai.
Sauniuniga masani:
Fua pe tusa ma le 100mg o le (R) -3-hydroxyprrolidine hydrochloride tulaga i totonu o se fagu, faʻaopopo le 1mL o le diluent ma faʻamavae.
Sauniuniga su'ega:
Fua pe tusa ma le 100mg o le su'ega fa'ata'ita'iga i totonu o se fagu, fa'aopoopo le 1mL ole fa'afefiloi ma solo.Sauni fa'alua.
Taualumaga:
Tu'i avanoa (diluent), tapenaga masani ma sauniuniga su'ega e fa'aaoga ai tulaga i luga ole GC.Fa'aleaogaina tumutumu ona o avanoa.Ole taimi ole taofi ole maualuga ona ole (R) -3-hydroxyprrolidine e tusa ma le 5.0min.
Fa'aaliga:
Lipoti le taunuuga o se averesi
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua ma le tuʻuina atu o (R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) faʻatasi ai ma le maualuga, faʻaaogaina lautele i le faʻaogaina o meaola, faʻasologa o vailaʻau faʻapitoa. ma Active Pharmaceutical Ingredient (API) synthesis.
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) o se vaeluaga masani i le tuufaatasiga o Panipenem (CAS 87726-17-8) ma Darifenacin hydrobromide (CAS 133099-07-7).
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) o se chiral hydroxy derivative o pyrrlodine faʻaaogaina i le sauniuniga o chiral niologically active compounds e pei o muscarinic receptor antagonists ma antimicrobial agents.
Auala o le Fa'asologa o (R)-3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile na faʻaalia i le trimethyl chlorosilane i le dichloromethane solvent e maua ai (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine na faʻapipiʻiina i luga o le Pd / C catalyst. (R) -3-trimethylsiloxyepyrrolidine na maua e le sodium hydroxide ring closing treatment.Mulimuli ane, o le (R) -3-hydroxypyrrolidine hydrochloride oloa na maua e ala i togafitiga faʻamaʻi faʻamaʻi hydrochloric ma aveese le vaega puipuia o le trimethylsilyl.
