(R)-Lansoprazole Dexlansoprazole CAS 138530-94-6 Su'ega 98.0~102.0% (HPLC) Falegaosimea
Ruifu Chemical Supply Lansoprazole Intermediates
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(R)-Lansoprazole Dexlansoprazole CAS 138530-94-6
Igoa Vailaau | (R)-Lansoprazole |
Synonyms | R-(+)-Lansoprazole;Dexlansoprazole;2-[(R)-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole;T 168390;TAK 390;Lansoprazole Le mama 14;Dexlansoprazole Fesoʻotaʻi Faʻaleagaina 2;(R)-2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-Benzimidazole; |
Numera CAS | 138530-94-6 |
CAT Numera | RF-PI1916 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
Fuafua mole | C16H14F3N3O2S |
Molecular Weight | 369.36 |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'epa'e i le Pa'u Pa'epa'e Pa'epa'e |
Solubility | Solu i le Dimethylformamide, Toeititi lava le mafai ona solu i le Vai |
Malamalama ma Lanu o Fofo | Faʻafetaui le Manaoga |
Faailoaina IR | E tatau ona ogatusa le fusi o le infrared absorption ma le mea fa'asino |
Fa'ailoga HPLC | O le taimi fa'amauina o le tumutumu autu e tatau ona ogatasi ma le taimi o le fa'asinomaga |
Ta'amilosaga Fa'apitoa | +142.0°~+149.0° |
Lisi Lisi | ~140.0℃ |
Suavai (KF) | <1.00% |
Toega i luga o le mumu | <0.10% |
Fa'aleaga Fa'atatau | (HPLC) |
Nitrogen Oxides | <0.10% |
Sulfone | <0.40% |
Sulfide | <0.20% |
So'o se isi mea le mama e tasi | <0.10% |
Aofa'i Fa'aleaga | <0.60% |
Mama'i Mata (HPLC) | >99.5% |
Su'ega | 98.0~102.0% (HPLC, % w/w, i luga o fa'avae anhydrous, solvent-free) |
Metala mamafa | <10ppm |
Solvents totoe | |
Toluene | <890ppm |
n-Heptane | <5000ppm |
Endotoxin siama | <2.5EU/mg |
Tulaga Su'ega | USP Standard;Saina Pharmacopoeia |
Fa'aoga | API;Ose Tu'ugutu Active Proton Pump Inhibitor |
afifi: Fagu, ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu
(R)-Lansoprazole (CAS: 138530-94-6) o le R enantiomer o Lansoprazole, Lansoprazole (AG 1749) o se faʻamalosi faʻamalosi faʻamalosi faʻamalosi e taofia ai le manava mai le gaosia o le suka.Dexlansoprazole mo Lansoprazole dextroisomer, o se ituaiga o vailaau anti peptic ulcer mo sui benzimidazole derivatives, i le fausaga mole i le elemene fluorine, omeprazole pamu proton lona lua ina ua mavae.Dexlansoprazole ei ai le aʻafiaga o le faʻalavelaveina o le gaʻo gaʻo, o le aʻafiaga e sili atu nai lo isi vailaʻau (Omeprazole, Pantoprazole, Rebela, Tetrazolium) e mafai ona matua taofia ai le tupu mai o le maʻi.E sili atu nai lo le famotidine poʻo le Omeprazole mo le faʻaleagaina o le mucosa gastric ma le maʻi o le duodenal e mafua mai i le ava malosi e mafua mai i le gaʻo.E le gata i lea, o le oloa e tutusa le anti Helicobacter pylori e pei o le bismuth preparation, ma e faʻaaogaina mo le reflux esophagitis ma le maʻi o le Zhuo AI.Takeda Pharmaceuticals na maua le fa'atagaga a le dexlansoprazole, o se fa'amavaega fa'alua o le (R)-isomer o le lansoprazole proton pump inhibitor (PPI) ua uma ona i ai i le maketi, mai le FDA ia Ianuari 2009. Dexlansoprazole o se pusa fa'amalolo tuai mo le tasi aso, togafitiga tautala. o le mu o le fatu e fesootaʻi ma faʻamaʻi faʻamaʻi e le o le gastroesophageal reflux (GERD), le faʻamaloloina o le esophagitis (EE) ma le tausiga o le EE faʻamalolo.