Ramelteon (TAK-375) CAS 196597-26-9 Mama>99.5% (HPLC)
Ta'ita'i Gaosi ma Fa'atau oloa, Intermediates a Ramelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-tasi CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
Please contact: alvin@ruifuchem.com
| Igoa Vailaau | Ramelteon |
| Synonyms | (S)-N-[2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethyl]propionamide;TAK-375;TAK375;TAK 375;Rozerema |
| Numera CAS | 196597-26-9 |
| CAT Numera | RF2885 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
| Fuafua mole | C16H21NO2 |
| Molecular Weight | 259.35 |
| Lisi Lisi | 113.0 i le 116.0 ℃ |
| Fa'apuna | 455.3±24.0℃ |
| Malosi | 1.119±0.06 g/cm3 |
| Ta'amilosaga Fa'apitoa [α]20/D | -55.0° i le -60.0° (C=1, CHCL3) |
| Solubility i le Vai | E le mafai ona fa'afefeteina ile Vai (11 mg/l 25℃) |
| Solubility | Solu i le Ethanol, Methanol, DMSO |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'u tioata Pa'epa'e |
| Mama / Suʻesuʻega Metotia | >99.5% (HPLC) |
| Lisi Lisi | 113.0~116.0 ℃ |
| Ma'imau ile Fa'amago | <0.50% |
| Toega i luga o le mumu | <0.10% |
| Isomer Mama | <0.10% |
| Metala mamafa | <10ppm |
| Acidity po'o Alkalinity | Fa'atatau |
| Ethanol | <5000ppm |
| Le mama nofofua | <0.20% |
| Aofa'i Fa'aleaga | <0.50% |
| Alaleo Infrared | E tusa ma le Fauga |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | API, Fa'amaonia mo le Togafitiga o le le moe |
afifi: Fagu, ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau
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Fa'ata'ita'iga?O le tele o oloa e maua ai faʻataʻitaʻiga e leai se totogi mo le iloiloga lelei, o tau o felauaiga e tatau ona totogi e tagata faʻatau.
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Ramelteon (CAS: 196597-26-9) na faʻamaonia muamua e le US Food and Drug Administration (FDA) ia Iulai 22, 2005, ona faʻamaonia lea e le Pharmaceuticals and Medical Devices Agency (PMDA) ile Apr 16, 2010. Na atiina ae ma maketiina o Rozerem® e Takeda,e mafai ona fa'aoga e togafitia ai le le mautonu ma le faigata ona momoe, ma e iai a'afiaga mautinoa i le le mautonu ma le le mautonu mo taimi pupuu.O lenei oloa e mafai ona fa'agaoioia le ituaiga 1 ma le ituaiga 2 fa'afofoga o le melatonin (MT1, MT2), fa'ateleina le moe o le galu (SWS) ma le moe vave o mata (REW), ma fa'aitiitia ai le le mautonu.Ramelteamide o le vailaʻau faʻamaʻi muamua e le o se vaisu e togafitia ai le insomnia e le o lalo ifo o le pule faʻapitoa.O lenei oloa o se agonist talitali melatonin.E i ai se sootaga maualuga ma le melatonin MT1 ma MT2 tali atu, ma ei ai se aafiaga faapitoa ma atoatoa agonistic i luga o le MT1 ma le MT2 tali, ae le fegalegaleai ma le tali MT3.E le gata i lea, e le fusifusia i le neurotransmitter receptors e pei o le GABA receptor complexes, ma e le faʻalavelave i le gaioiga o le tele o enzymes i totonu o se vaega.O le mea lea, e mafai ona aloese mai le faʻalavelave e fesoʻotaʻi ma vailaʻau GABA (lea e ono mafua ai faʻalavelave tau taavale, pa'ū ma gau).Etc.) ma vaisu o fualaau faasaina ma le faalagolago.Rozerem® o lo'o maua e pei o se laupepa e ufiufi ata mo le fa'aoga tautala, e iai le 8 mg o le Ramelteon e leai se totogi.Ole fua fa'atonu mo tagata matutua e 8 mg e ave ile 30 minute ole moe.
