Ramelteon Intermediate 12 CAS 1053239-39-6 Mama>98.0% (HPLC)
Ta'ita'i Gaosi ma Fa'atau oloa, Intermediates a Ramelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-tasi CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
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| Igoa Vailaau | 2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride |
| Synonyms | Ramelteon Intermediate 12;Ramelteon Stage-2 Le mama;1,6,7,8-Tetrahydro-2H-Indeno[5,4-B] Furan-8-Ethanamine Hydrochloride |
| Numera CAS | 1053239-39-6 |
| CAT Numera | RF2887 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
| Fuafua mole | C13H18ClNO |
| Molecular Weight | 239.74 |
| Lisi Lisi | 165.0~167.0 ℃ |
| Malosi | 1.058±0.06g/cm3 |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e Malosi |
| Mama / Suʻesuʻega Metotia | >98.0% (HPLC) |
| Ma'imau ile Fa'amago | <1.00% |
| Le mama nofofua | <1.00% |
| Aofa'i Fa'aleaga | <2.00% |
| 1 H NMR Alaleo | Osi ma le Fauga |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | Intermediate of Ramelteon (CAS: 196597-26-9) |
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2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride (CAS: 1053239-39-6) o se vaeluaga o Ramelteon (CAS: 196597- 26-9).E le pei o le tele o togafitiga o le le mautonu o loʻo faʻatatau i le GABA (g-aminobutyric acid) receptor complex, Ramelteon o se agonist o le melatonin receptor.Aemaise lava, e maualuga lona filifilia mo le MT1 ma le MT2 subtypes, lea na aʻafia i le tausiga o circadian rhythms, i luga o le MT3 receptor nafa ma isi galuega melatonin.O le leai o se vavalalata mo e le gata i le GABA receptor complex ae faʻapea foʻi le neurotransmitter, dopaminerigic, opiate, ma le benzodiazepine receptors e faʻaalia ai se faʻaleleia atili o le saogalemu e aunoa ma le faʻaleagaina o vailaʻau faʻamaʻi e faʻatatau i nei tali.E pei o lea, o Ramelteon e le o se vailaʻau faʻatulagaina.Metabolites Primary e aofia ai le hydroxylation ma oxidation i ituaiga carbonyl ma metabolites lona lua e mafua mai i le glucuronidation.Talu ai o le CYP1A2 o le isozyme tele lea e aʻafia i le metabolism o le ate o Ramelteon, e le tatau ona faʻaaogaina faʻatasi ma le malosi o le CYP1A2 inhibitors, pei o le fluvoxamine.Faʻatasi faʻatasi ma le ketoconazole (se inhibitor CYP3A4) poʻo le fluconazole (o se inhibitor malosi CYP2C9) na mafua ai le faʻateleina o le AUC ma le Cmax, ae o le tele o le metabolism ma le maualuga o le fesuiaiga o plasma concentrations o Ramelteon na taofia ai le manaʻomia o le suiga o fualaau.Ae ui i lea, o le afifi o loʻo faʻapipiʻiina, e lapataia ai tagata mamaʻi e uiga i le faʻaogaina faʻatasi ma le malosi o le CYP3A4 ma le CYP2C9 inhibitors.Faʻavae i luga o le taunuʻuga o suʻesuʻega a le falemaʻi, o le fua fautuaina o Ramelteon o le 8mg e ave i totonu ole 30 minute ole alu e moe.I le faaopoopo atu i le puipuiga o le faʻatasi ma le CYP inhibitors, e le tatau ona faʻaaogaina i tagata mamaʻi e ogaoga le faʻaleagaina o le ate.O mea leaga na tutupu, na matauina i le 5% o tagata gasegase i suʻesuʻega faʻapitoa, o le moe, niniva, faufau, vaivai, ulu tiga, ma le le mautonu.
