Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Tulaga Maualuga
Gaosi Fa'atauga Fa'atauga Remdesivir ma Feso'ota'i Fesoota'iga ma le Tulaga Maualuga
Remdesivir CAS 1809249-37-3
2-Ethyl-1-butanol CAS 97-95-0
Trimethylsilyl Cyanide CAS 7677-24-9
4-Nitrophenol CAS 100-02-7
2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate CAS 1911578-98-7
N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester CAS 1354823-36-1
(S)-2-Ethylbutyl 2-Aminopropanoate Hydrochloride CAS 946511-97-3
Remdesivir Metabolite (GS-441524) CAS 1191237-69-0
Remdesivir N-2 Intermediate CAS 1191237-80-5
2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine CAS 937046-98-5
Pyrrolo[1,2-F][1,2,4]Triazin-4-Amine CAS 159326-68-8
4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine CAS 1770840-43-1
Igoa Vailaau | Remdesivir |
Synonyms | GS-5734;2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo [2,1-f][1,2,4] triazin-7-yl)-5-cyano -3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate |
Numera CAS | 1809249-37-3 |
CAT Numera | RF-API96 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
Fuafua mole | C27H35N6O8P |
Molecular Weight | 602.58 |
Malosi | 1.47±0.1g/cm3 |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e Malosi |
Faailoaina A | IR: Ole alaleo ole absorption infrared o le oloa e tatau ona ogatasi ma le mea o lo'o fa'asino i ai |
Faailoaga B | HPLC Taimi fa'atumauina tutusa ma mea fa'asino |
Ta'amilosaga Fa'apitoa | -19.0° ~ -22.0° |
Solubility | Solunle i le Methanol, Fa'ase'e Solu i le Ethanol, La'ititi Solu i le Acetonitrile, Fa'ata'ita'i le solu i le Vai |
Mea Fa'atatau | |
So'o se Fa'aleaga Ta'ito'atasi | ≤0.10% |
Aofa'i Fa'aleaga | ≤1.0% |
RD-3.1 | ≤0.10% |
RD-C | ≤0.10% |
RD-D | ≤0.10% |
RD-E | ≤0.10% |
RP-Isomer | ≤0.10% |
Nitrophenol | ≤0.10% |
Solvents totoe | |
Methanol Dichloride | ≤6000ppm |
Acetone | ≤5000ppm |
Isopropyl Alcohol | ≤5000ppm |
Acetonitrile | ≤410ppm |
Dichloromethane | ≤600ppm |
Methyl tert Butyl Eteru | ≤5000ppm |
Ethyl Acetate | ≤5000ppm |
Tetrahydrofuran | ≤720ppm |
n-Heptane | ≤5000ppm |
Su'ega | 98.0%~102.0% (Fa'atatau ile fa'amamago) |
Faitauga Aerobic Aofa'i | |
Aerobic Bacteria | ≤100cfu/g |
Faafefete ma Mold | ≤10cfu/g |
E. Coil | Le lelei |
Endotoxin siama | ≤1.0EU |
Metala mamafa | ≤20ppm |
Tulaga Su'ega | Pisinisi Tulaga |
Fa'aoga | API, COVID-19 |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Remdesivir (CAS 1809249-37-3), faʻatau atu i lalo o le igoa Veklury, o se vailaʻau faʻamaʻi lautele lautele na atiaʻe e le kamupani biopharmaceutical Gilead Sciences.E faia e ala ile tui ile vein.I le taimi o le faʻamaʻi COVID-19, na faʻatagaina le remdesivir pe faʻatagaina mo faʻalavelave faʻafuaseʻi e togafitia ai le COVID-19 i totonu ole 50 atunuu.Faʻafouina taʻiala mai le Faalapotopotoga o le Soifua Maloloina a le Lalolagi ia Novema 2020 e aofia ai le faʻatonuga faʻasaga i le faʻaaogaina o le Remdesivir mo togafitiga ole COVID-19.O le Remdesivir na faia muamua e togafitia ai le hepatitis C, ma sa suʻesuʻeina mulimuli ane mo le Ebola virus faʻamaʻi ma le Marburg virus faʻamaʻi aʻo leʻi suʻesuʻeina o se togafitiga pe a maeʻa le faʻamaʻi mo le COVID-19.Ole a'afiaga sili ona taatele ile volenitia soifua maloloina ole si'itia lea ole toto ole enzymes ole ate (se fa'ailoga ole fa'afitauli ole ate).Ole a'afiaga pito sili ona taatele i tagata e maua ile COVID-19 ole fa'afofo.O a'afiaga e ono aofia ai le fula o le ate ma se fa'alavelave e feso'ota'i ma le fa'afuifu ma le faufau, maualalo le toto toto, ma le afu.O le Remdesivir o se vailaʻau e faʻamoemoe e faʻatagaina ai le tuʻuina atu o le GS-441524 monophosphate i totonu o le sela ma le biotransformation mulimuli ane i le GS-441524 triphosphate, o le ribonucleotide analog inhibitor o viral RNA polymerase.