Roflumilast CAS 162401-32-3 Su'ega 99.0~101.0% API
Ruifu Sapalai Vailaau Matautia Roflumilast Intermediates:
Roflumilast CAS 162401-32-3
4-Amino-3,5-Dichloropyridine CAS 22889-78-7
Igoa Vailaau | Roflumilast |
Synonyms | 3-(Cyclopropylmethoxy)-N-(3,5-Dichloropyridin-4-yl)-4-(Ddifluoromethoxy)benzamide |
Numera CAS | 162401-32-3 |
CAT Numera | RF-PI2075 |
Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
Fuafua mole | C17H14Cl2F2N2O3 |
Molecular Weight | 403.21 |
Malosi | 1.471±0.060g/cm3 |
Ma'ale'ale | Ma'ale'ale vevela |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'epa'e po'o le Toeitiiti Pa'epa'e Pa'u tioata |
Solubility | E mafai ona solu i le acetone, e itiiti le solu i le acetronitrile, e le mafai ona solu i le anhydrous ethanol, toetoe lava a le mafai ona solu i le vai. |
Lisi Lisi | 157.0~162.0 ℃ |
Ma'imau ile Fa'amago | <0.50% |
Toega i luga o le mumu | ≤0.10% |
Metala mamafa | ≤10ppm |
Klorida | ≤0.01% |
Fa'ailoga A. UV | Ole umi ole galu ole maualuga ole absorption e tatau ile 213~251nm |
Faailoaga B. IR | Ole fusi ole fa'ata'ita'iga ole fa'ata'ita'iga ole IR e fetaui ma le fa'amatalaga ole tasi |
Faailoaina C. | O lo'o fa'aalia ai le fa'aalia o le Fluoride |
Mea Fa'atatau | |
Le mama nofofua | ≤0.10% |
Aofa'i Fa'aleaga | <0.50% |
Solvents totoe | |
Tert-Butanol | <0.10% |
Tetrahydrofuran | <0.072% |
Toluene | <0.089% |
N,N-Dimethylformamide | <0.088% |
Su'ega | 99.0~101.0% (Fa'atatau ile Fa'amamago) |
Tulaga Su'ega | Pisinisi Tulaga |
Fa'aoga | API;COPD |
afifi: Fagu, ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu
Roflumilast (CAS: 162401-32-3) o se fa'amalosaga oral phosphodiesterase-4 (PDE-4) filifilia ma se vailaʻau benzamide.Na atiaʻe e le kamupani Siamani Altana i le 1993 ma e na o le pau lea o le PDE-4 inhibitor tautala na faʻaaogaina e togafitia ai faʻamaʻi o le manava ua faʻatagaina mo le faʻatau.O le Roflumilast o le vailaʻau muamua o lona ituaiga e faʻatatau i faʻamaʻi faʻamaʻi faʻamaʻi faʻamaʻi (COPD), ma o le vailaʻau muamua foʻi faʻamaʻi faʻamaʻi faʻapitoa na atiaʻe mo maʻi COPD.O ona uiga tulaga ese e mafai ona fesoasoani e faʻatonutonu le COPD: pe a faʻaaogaina faʻatasi ma bronchodilators e togafitia ai tagata maʻi COPD sili ona ogaoga, e mafai e Roflumilast ona maua le avanoa e faʻaitiitia ai faʻamaoniga ma le faʻaleagaina o le fua, ma avea ai ma vailaʻau muamua e taulaʻi ai tagata mamaʻi ma faʻalavelave faʻafuaseʻi phenotype-spAecific COPD ma fa'alavelave tele le tafega o le ea e feso'ota'i ma le tale umi ma le tele o le pala.E ese mai i le avea o se togafitiga mo COPD ogaoga, e mafai foi ona faʻaaogaina Roflumilast e puipuia ma togafitia ai faʻamaʻi o le manava o lafumanu, tale bronchitis mucosa sili, bronchitis asthmatic, ma le bronchitis maʻi ma le sacculitis ea faʻatasi ma le faʻaogaina o le manava manava.