(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1 Ibrutinib Vaeluaga Mama >99.0% (GC)
Igoa Vailaau | (S)-1-Boc-3-Hydroxypiperidine |
Synonyms | (S)-1-(tert-Butoxycarbonyl)-3-Hydroxypiperidine;(S)-1-Boc-3-Piperidinol |
Numera CAS | 143900-44-1 |
CAT Numera | RF-CC299 |
Tulaga Fa'asoa | I totonu o faʻatauga, Gaosi gaosiga 20 Tone/Masina |
Fuafua mole | C10H19NO3 |
Molecular Weight | 201.27 |
Lisi Lisi | 52.0~56.0 ℃ |
Solubility | Solu i le Methanol |
Ta'amilosaga Fa'apitoa [a]20/D | +9.0°~+11.0° (C=1 ile Chloroform) |
Fa'ailoga | Ruifu Chemical |
Aitema | Fa'amatalaga |
Fa'aaliga | Pa'u Pa'epa'e po'o tioata |
Chiral Mama | >99.5% (GC) |
Vailaau Mama | >99.5% (GC) |
Vai (KF) | ≤0.50% |
Methanol (GC) | ≤50ppm |
Ethanol (GC) | ≤50ppm |
DCM (GC) | ≤500ppm |
3-Hydroxypiperidine | ≤0.10% |
3-Hydroxypyridine | ≤0.20% |
1-Boc-3-Piperidone | ≤0.10% |
1-Boc-4-Hydroxypiperidine | ≤0.10% |
1.96 RRT | ≤0.20% |
So'o se mea le mama e le o ta'ua | ≤0.10% |
Tulaga Su'ega | Pisinisi Tulaga |
Fa'aoga | Vailaau Fa'atekonolosi;Chiral Compounds |
afifi: Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu.
(S) -1-Boc-3-Hydroxypiperidine (CAS: 143900-44-1) o se mea taua tele mo le tuʻufaʻatasia o Ibrutinib (CAS: 936563-96-1).Ibrutinib o se ituaiga o Bruton tyrosine kinase (BTK) inhibitor, e mafai ona faʻaaogaina mo le togafitia o le leukemia lymphocytic masani (CLL) ma le lymphoma sela (MCL).O le MCL ma le CLL e a'afia i le B-cell non-Hodgkin's lymphoma, lea e faigata ona fofo ma faigofie ona toe tupu.Ole fa'ama'i fa'ama'i masani e leai se fa'atatau, e masani ona tupu ile 3 pe 4 fa'alavelave leaga.Ibrutinib ma B lymphocytes e mafai ona taulaʻi i le BTK lea e manaʻomia mo le faʻavaeina, faʻavasegaina, ma le tuʻuina atu o faʻamatalaga, faʻalavelaveina le gaioiga o le BTK e le mafai ona toe faʻafoʻisia, ma faʻalavelaveina le tuputupu aʻe o le tumo ma le ola lelei.Ibrutinib e mafai ona vave faʻafefe pe a uma le tautala tautala, i le taimi o le 1 ~ 2h e oʻo atu i le maualuga o le toto maualuga, o aʻafiaga leaga e tasi pe lua, o le mea lea, o le a avea Ibrutinib ma se filifiliga fou o togafitiga o CLL ma MCL.