Sorafenib CAS 284461-73-0 Mama ≥99.0% (HPLC) API Falegaosi Mea Maualuluga
Sapalai Pisinisi Sorafenib Tosylate ma Fesoota'iga Fa'atatau:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS: 327-78-6
| Igoa | Sorafenib |
| Synonyms | Sorafenib Free Base |
| Numera CAS | 284461-73-0 |
| CAT Numera | RF-API04 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
| Fuafua mole | C21H16ClF3N4O3 |
| Molecular Weight | 464.82 |
| Malosi | 1.454±0.06 g/cm3 |
| Solubility | Solu i le DMSO |
| Tulaga Va'a | Ambient Temperature |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e i le Pa'epa'e Pa'epa'e |
| Mama / Suʻesuʻega Metotia | ≥99.0% (HPLC) |
| Fa'ailoaga | H-NMR, MS |
| Ma'imau ile Fa'amago | ≤1.0% |
| Toega i luga o le mumu | ≤0.10% |
| Le mama nofofua | ≤0.20% (HPLC) |
| Aofa'i Fa'aleaga | ≤1.0% (HPLC) |
| Metala mamafa | ≤20ppm |
| Malamalama ole Fofo | Fa'atatau ile Fa'atonu |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | RCC & HCC |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Sorafenib Tosylate (CAS: 475207-59-1) o se ituaiga fou o le tele-target antitumor vailaʻau, na atiaʻe e le German Bayer Pharmaceuticals, ma faʻaalia le tele o gaioiga faʻamaʻi i suʻega manu.Sorafenib o loʻo maua i le 200-mg papa mo le faʻaogaina tautala ma faʻaaogaina i togafitiga o le RCC ma le HCC.Sorafenib Tosylate (CAS: 475207-59-1) e mafai i le taimi lava e tasi ona afaina ai sela tumo ma alatoto toto.E iai lona a'afiaga fa'alua fa'aantitumor: e mafai ona poloka le auala fa'aliliuina o fa'ailo o le sela e fa'asalalauina e le RAF/MEK/ERK e fa'alavelave sa'o ai le tuputupu a'e o le tumo, a'o fa'alavelaveina fo'i le VEGF ma mea e maua mai ai le tuputupu a'e o platelet (PDGF) e puipuia ai le fausia o le toto toto fou. va'a, ma fa'apea e taofia ai le tuputupu a'e o sela tumo.Sorafenib o se inhibitor o Raf-1 ma B-RAF faʻapea foʻi ma le tele o tyrosine kinases.
