Sorafenib Tosylate CAS 475207-59-1 Mama ≥99.0% (HPLC) API Falegaosi Mea Maualuluga
Sapalai Pisinisi Sorafenib Tosylate ma Fesoota'iga Fa'atatau:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS: 327-78-6
| Igoa Vailaau | Sorafenib Tosylate |
| Synonyms | Nexavar;4-[4-[3-[4-Chloro-3-(Trifluoromethyl)phenyl]ureido]phenoxy]-N-Methylpicolinamide 4-Methylbenzenesulfonate;4-[4-[[4-Chloro-3-(Trifluoromethyl)phenyl]carbamamido]phenoxy]-N-Methyl-2-Pyridinecarboxamide 4-Methylbenzenesulfonate;BAY 43-9006 Tosylate |
| Numera CAS | 475207-59-1 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
| Fuafua mole | C21H16ClF3N4O3.C7H8O3S |
| Molecular Weight | 637.03 |
| Lisi Lisi | 225.0 i le 230.0 ℃ |
| Ma'ale'ale | Ma'ale'ale ea, Ma'ale'ale vevela |
| Solubility | Solu i le Vai (<1 mg/ml) ile 25℃, DMSO (127 mg/ml) ile 25℃, ma le Ethanol (<1 mg/ml) ile 25℃ |
| Tulaga Va'a | Nofoaga malulu & mago (2 ~ 8 ℃), Puipui mai le Malamalama |
| COA & MSDS | Avanoa |
| Ola Fa'asa | 2 Tausaga pe a teu lelei |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga | I'uga |
| Fa'aaliga | Malamalama Samasama poʻo Paʻepaʻe Paʻu | E usitaia |
| Mama / Suʻesuʻega Metotia | ≥99.0% (HPLC) | 99.8% |
| Lisi Lisi | 225.0~230.0 ℃ | E usitaia |
| Metala mamafa | ≤10ppm | <10ppm |
| Ma'imau ile Fa'amago | ≤0.50% | 0.12% |
| Toega i luga o le mumu | ≤0.20% | 0.10% |
| So'o se Fa'aleaga Ta'itasi | ≤0.50% | E usitaia |
| Aofa'i Fa'aleaga | ≤0.50% | E usitaia |
| NMR Alaleo | E tusa ma le Fauga | E usitaia |
| Tulaga Su'ega | Pisinisi Tulaga | E usitaia |
| Fa'aoga | Sorafenib Tosylate (CAS: 475207-59-1) ile togafitiga ole RCC & HCC | |
afifi:Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Teu i totonu o se atigipusa tapuni.Teu i totonu o se faleteuoloa malulu, mago (2 ~ 8 ℃) ma fa'alelei lelei mai mea e le fetaui.Puipui mai le malamalama ma le susu.
Va'a:Tu'u atu ile lalolagi atoa ile ea, ile FedEx / DHL Express.Tuuina atu vave ma faatuatuaina tiliva.
Fa'ailoga Tulaga lamatia 36/37/38 - Fa'aitaita'i i mata, faiga manava ma le pa'u.
Fa'amatalaga Saogalemu S28 - A uma ona fa'afeso'ota'i ma le pa'u, fufulu vave i le tele o fasimoli.
S26 - Pe a pa'i i mata, fufulu vave i le tele o vai ma saili fautuaga faafoma'i.
Sorafenib Tosylate (CAS: 475207-59-1) o se ituaiga fou o le tele-target antitumor vailaʻau, na atiaʻe e le German Bayer Pharmaceuticals, ma faʻaalia le tele o gaioiga faʻamaʻi i suʻega manu.Sorafenib o loʻo maua i le 200-mg papa mo le faʻaogaina tautala ma faʻaaogaina i togafitiga o le RCC ma le HCC.Sorafenib Tosylate e mafai i le taimi e tasi ona aʻafia ai sela tumo ma alatoto toto.E iai lona a'afiaga fa'alua fa'aantitumor: e mafai ona poloka le auala fa'aliliuina o fa'ailo o le sela e fa'asalalauina e le RAF/MEK/ERK e fa'alavelave sa'o ai le tuputupu a'e o le tumo, a'o fa'alavelaveina fo'i le VEGF ma mea e maua mai ai le tuputupu a'e o platelet (PDGF) e puipuia ai le fausia o le toto toto fou. va'a, ma fa'apea e taofia ai le tuputupu a'e o sela tumo.
Sorafenib Tosylate, igoa tau fefaʻatauaʻiga Nexavar, na muamua fausia e Bayer Pharmaceuticals i Siamani.Sorafenib Tosylate o se inhibitor multi-kinase e mafai ona faʻaaogaina e togafitia ai faʻamaʻi e pei o le kanesa.Ia Tesema 2005, na faʻamaonia e le US FDA e avea o se vailaʻau muamua mo le togafitiga o le kanesa renal maualuga.Ia Aukuso 2009, na lisiina aloaia i Saina ma le faʻatagaina a le Setete o Meaʻai ma Fualaau Faʻasaina.
Sorafenib Tosylate o tyrosine kinases (VEGFR ma PDGFR) ma RAF / MEK / ERK cascade inhibitors, galue i le taimi lava e tasi i luga o Raf-1, wtBRAF ma V599EBRAF, ma IC50 o 6 nM, 22 nM ma 38 nM, faasologa.
E mafai e le Sorafenib Tosylate ona taofiofia i le taimi e tasi le tele o kinases o loʻo iai i luga o le cell ma le cell surface, e aofia ai le RAF kinase, vascular endothelial growth factor receptor-2 (VEGFR-2), vascular endothelial growth factor receptor-3 (VEGFR-3), platelet -e maua mai le tuputupu aʻe o le tali-β (PDGFR-β), KIT ma le FLT-3.E mafai ona va'aia o le sorafenib toluenesulfonate e lua a'afiaga o le tumor.I le tasi itu, e mafai ona taofia tuusaʻo le tuputupu aʻe o le tumo e ala i le faʻasaina o le ala faʻailoga RAF / MEK / ERK;i le isi itu, e mafai ona taofia VEGFR ma PDGFR.Ma poloka le faʻavaeina o le neovascularization tumo, faʻalavelave faʻafuaseʻi le tuputupu aʻe o sela tumo.O le Sorafenib Tosylate o le vailaʻau sili ona aoga mo le togafitia o le kanesa o le ate faʻasolosolo e ala i pulega faʻapitoa, ma e foliga mai o le a avea ma vailaʻau fou mo togafitiga o lenei maʻi.
O le Sorafenib Tosylate i aso taʻitasi o le tuʻuina atu o faʻataʻitaʻiga faʻataʻitaʻiga faʻataʻitaʻiga o le tuʻuina atu o manu tumo tagata na faʻaalia ai le tele o gaioiga e tetee atu ai i le pumo, e aofia ai le kanesa o le kolone, le kanesa o le tino laiti, kanesa o le susu, melanoma, kanesa o le pancreatic, leukemia ma le kanesa ovarian ma le faʻamaʻi totoga o le isumu. fa'ata'ita'iga, fa'ata'ita'iga RENCA.
