Temozolomide (TMZ) CAS 85622-93-1 Su'ega 99.0%~101.0% API Falegaosi Ma'a Maualuga
Tu'uina atu Temozolomide ma Fesoota'iga Fa'atatau:
Temozolomide CAS: 85622-93-1
4(5)-Amino-5(4)-Imidazolecarboxamide CAS: 360-97-4
5(4)-Amino-4(5)-Imidazolecarboxamide Hydrochloride CAS: 72-40-2
| Igoa Vailaau | Temozolomide |
| Synonyms | 3,4-Dihydro-3-Methyl-4-Oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-Carboxamide |
| Numera CAS | 85622-93-1 |
| CAT Numera | RF-API29 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i Tone |
| Fuafua mole | C6H6N6O2 |
| Molecular Weight | 194.15 |
| Lisi Lisi | 212 ℃ Tes. |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e i le Pa'u piniki Malamalama |
| Fa'ailoaga | Saunia e IR, HPLC |
| Solvents totoe | Dimethyl Sulphoxide ≤0.50% |
| Mea Fa'atatau | |
| Le mama AIC | ≤0.10% |
| Le mama nofofua | ≤0.10% |
| Malolo Le Malamalama Leila | ≤0.30% |
| Aofa'i Fa'aleaga | ≤0.30% |
| Metala mamafa | ≤10ppm |
| Ma'imau ile Fa'amago | ≤0.50% |
| Toega i luga o le mumu | ≤0.10% |
| Su'ega | 99.0%~101.0% (HPLC ile fa'amamago) |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | Mea Fa'afoma'i Gaoioiga (API) |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua ma le tuʻuina atu o Temozolomide (CAS: 85622-93-1) faʻatasi ai ma le maualuga.Temozolomide (TMZ) o se vailaʻau alkylating tautala faʻaaogaina e togafitia ai le Glioblastoma Multiforme (GBM) ma Astrocytomas, Metastatic Melanoma.
Temozolomide o le vailaʻau faʻamaʻi faʻamaʻi muamua imidazole ma le tetrazine-class anticancer lea e aʻafia i le tupulaga lona lua o le alkylating agent faʻatasi ai ma le antitumor gaioiga e aunoa ma le faʻamalosia o le ate pe a uma le faʻaogaina o le gutu.E faʻaalia i le faigofie ona tuʻuina atu i le paʻu o le toto-faiʻai, faʻapalepale lelei ma le le faʻapipiʻiina ma isi vailaʻau oona, ma le i ai o le synergistic aafiaga ma le radiotherapy lea e talafeagai mo le togafitia o le toe foʻi mai o le glioma leaga pe a uma togafitiga masani e pei ole glioblastoma multiforme tuma poʻo le degenerative astrocytoma.Ole vaila'au ole laina muamua mo togafitiga ole metastatic melanoma.
Temozolomide na muamua tu'ufa'atasia e le Cancer Research UK Group, ona tu'uina atu lea i le Kamupani Schering-Plough (Amerika) mo le atina'e.O lo'o i ai se fa'asologa o vaila'au fou ma o lo'o i ai i se fa'avae fa'a-imidazole.I le 1999, ua faʻatagaina mo le ulufale atu i totonu o le maketi i totonu o le EU ma le US lea o le faʻatagaina faʻatagaina i le Iunaite Setete e masani lava mo togafitiga lona lua o le glioblastoma multiforme ma le degenerative star gliomas ma faʻamaoniga faʻamaonia a le EU mo le togafitia o le atinaʻeina poʻo le toe faʻafoʻi glioblastoma multiforme. lea ua uma ona fai i togafitiga masani.O le aoga o le temozolomide i le togafitia o le glioblastoma multiforme ua sili atu le faʻaaloalogia i Europa.
