trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Mama >98.0% (HPLC) Afatinib Dimaleate Intermediate

Fa'amatalaga Puupuu:

trans-4-Dimethylaminocrotonic Acid Hydrochloride

CAS: 848133-35-7

Mama: >98.0% (HPLC)

Fa'aaliga: Pa'epa'e e Toeitiiti a Pa'epa'e

Intermediate of Afatinib Dimaleate (CAS: 850140-73-7)

Fa'afeso'ota'i: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Fa'amatalaga Oloa

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Fa'amatalaga:

Ruifu Sapalai Vailaau Fa'alava ole Afatinib
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Meatotino tau vailaau:

Igoa Vailaau	trans-4-Dimethylaminocrotonic Acid Hydrochloride
Synonyms	trans 4-Dimethylaminocrotonic Acid HCl;(E)-4-(Dimethylamino)-2-Butenoic Acid Hydrochloride;(E)-4-Dimethylaminocrotonic Acid Hydrochloride;(2E)-4-(Dimethylamino)ae-2-Enoic Acid Hydrochloride;Afatinib int-2
Numera CAS	848133-35-7
Tulaga Fa'asoa	I Fa'atauga, Fua Fa'atau
Fuafua mole	C6H12ClNO2
Molecular Weight	165.62
Ma'ale'ale	Hygroscopic.Susū ma'ale'ale
Lisi Lisi	160.0 i le 164.0 ℃
Solubility	DMSO (Teisi), Methanol (Teisi), Suavai (Teisi)
COA & MSDS	Avanoa
Amataga	Shanghai, Saina
Fa'ailoga	Ruifu Chemical

Fa'amatalaga:

Aitema	Fa'amatalaga
Fa'aaliga	Pa'epa'e ile Toeitiiti Pa'epa'e Pa'u
Mama / Suʻesuʻega Metotia	>98.0% (HPLC)
Mama / Suʻesuʻega Metotia	>98.0% (NMR)
Susū (KF)	<0.50%
Toega i luga o le mumu	<0.20%
Le mama nofofua	<0.50%
Metala mamafa (pei o le Pb)	<20ppm
Alaleo Infrared	E tusa ma le Fauga
1 H NMR Alaleo	Proton NMR Alaleo
Tulaga Su'ega	Pisinisi Tulaga
Fa'aoga	Intermediate of Afatinib, Afatinib Dimaleate

Paket & Teuina:

afifi:Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.

Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama ma le susu.

Va'a:Tu'u atu ile lalolagi atoa ile ea, ile FedEx / DHL Express.Tuuina atu vave ma faatuatuaina tiliva.

Chromatographic mama:

Meafaigaluega: Agilent 1200 HPLC HPLC chromatograph, DAD detector.
Koluma: Agilent XDB-C18,250*4.6mm, 5μm
Vaega feavea'i: B: 1.95g sodium octane sulfonate + 8ml phosphoric acid + 5ml triethylamine + 500ml vai
C: acetonitrile
Sauniuniga ole vaega fefiloi fefiloi: ave le 400ml B solution ma le 100ml acetonitrile, faʻafefiloi lelei ma tutusa, ma pamu le vai i le tasi vaega.
Fuafuaga tafe: 0.5ml/min54bar
Koluma vevela: 25℃
Umi ole galu: 210nm
Faʻataʻitaʻiga fofo: faʻaogaina le vaega feaveaʻi e pei o le solvent, faʻataʻitaʻiga malosi: 0.0040g / 2ml, faʻataʻitaʻiga tele 2.0μl.

Tulaga lelei:

FAQ:

Talosaga:

trans-4-Dimethylaminocrotonic Acid Hydrochloride (CAS: 848133-35-7) o se reagent faʻaaogaina i le sauniuniga o le tyrosine kinase faʻalavelave faʻamaʻi faʻamaʻi.trans-4-Dimethylaminocrotonic Acid Hydrochloride e mafai ona faʻaaogaina e avea o se vaeluaga o Afatinib (CAS: 439081-18-2), Afatinib Dimaleate (CAS: 850140-73-7), Neratinib (CAS: 698387-09-6).Afatinib o se vailaʻau faʻamaonia mo le togafitiga e le o ni tamaʻi sela mama mama (NSCLC), na atiaʻe e Boehringer Ingelheim.E galue o se inhibitor angiokinase.E pei o Lapatinib ma Neratinib, o le Afatinib o le tyrosine kinase inhibitor (TKI) lea e le mafai foi ona faʻalavelaveina le tagata epidermal growth factor receptor 2 (Her2) ma le epidermal growth factor receptor (EGFR) kinases.Afatinib e le gata o loʻo galue faasaga i le EGFRsuiga o lo'o fa'atatau ile tupulaga muamua TKI e pei o le gefitinib po'o le gefitinib, ae fa'asaga ia i latou e le maaleale i nei togafitiga masani.Ona o lana gaioiga faaopoopo faasaga ia Her2, o loʻo suʻesuʻeina mo le kanesa o le susu faʻapea foʻi ma isi faʻamaʻi EGFR ma Her2.Neratinib na atiaʻe e le US Wyeth kamupani o se mea e le mafai ona faʻaaogaina epidermal growth factor receptor (EGFR) inhibitor.Ose vaega fa'atatau e tele o tama'i molecule tyrosine kinase inhibitors i le HER 2 ma le HER1 pe a uma Lapatinib, ma o se ErbB receptor tyrosine kinase inhibitor e le mafai ona fa'afoliga.Neratinib e mafai ona filifili fa'alavelave HER-1 ma HER-2 ole aiga EGFR (IC50 e 92 nmol/L ma le 59 nmol/L, fa'asologa).O su'esu'ega fa'afoma'i na fa'aalia ai o le Neratinib na fa'atinoina le tele o le fa'amalologa i le kanesa o le mama e le o ni sela laiti, kanesa colon, ma le kanesa o le susu.O le faʻataʻitaʻiga faʻataʻitaʻi faʻataʻitaʻi faʻataʻitaʻiga na faʻaalia ai o le Neratinib na faʻaalia le lelei ma le faʻapalepale i tagata mamaʻi HER-2 maʻi maʻi maʻi maualuga le kanesa o le susu na maua pe leai foi Trastuzumab togafitiga.O le vaega Ⅲ fa'ata'ita'iga o le kanesa o le susu na mae'a ia Setema 2014.