Vitamini E-TPGS (Tocofersolan) CAS 9002-96-4 D-α-Tocopherol ≥25.0%
Shanghai Ruifu Chemical Co., Ltd. o le taʻutaʻua taʻutaʻua o Vitamin E-TPGS (Tocofersolan) (CAS: 9002-96-4) faʻatasi ai ma le maualuga.Ruifu Chemical e mafai ona tuʻuina atu i le lalolagi atoa, tau faʻatauvaʻa, auaunaga sili ona lelei, laʻititi ma tele tele o loʻo avanoa.Fa'atau Vitamin E-TPGS,Please contact: alvin@ruifuchem.com
| Igoa Vailaau | Vitamin E Polyethylene Glycol Succinate |
| Synonyms | Vitamini E-TPGS;TPGS;Tocofersolan;α-Tocopherol Polyethylene Glycol Succinate;D-α-Tocopherol Polyethylene Glycol 1000 Succinate;alpha-Tocopherol Polyethylene Glycol Succinate |
| Tulaga Fa'asoa | I Fa'atauga, Fua Fa'atau |
| Numera CAS | 9002-96-4 |
| Fuafua mole | C33H54O5.(C2H4O)n |
| Lisi Lisi | 34.0~38.0 ℃ |
| Malosi | 1.01g/cm3 |
| Ma'ale'ale | Ma'ale'ale Ea, Ma'ale'ale Ma'ale'ale, Susū ma'ale'ale |
| WGK Siamani | 2 |
| Temp. | Nofoaga malulu ma mago (2~8℃) |
| COA & MSDS | Avanoa |
| Fa'ata'ita'iga | Avanoa |
| Aiga Vailaau | Vitamini E maua mai |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Tulaga Fa'atonu | I'uga |
| Fa'aaliga | Pa'epa'e-Pa'epa'e i'u'ula'i Samasama Su'e Su'e | E usitaia |
| Fa'ailoaga (GC) | Ole taimi fa'atumauina ole tumutumu tele ole fofo fa'ata'ita'i e fetaui ma le vaifofo masani | E usitaia |
| Lisi Lisi | 34.0~38.0 ℃ | 36.0~36.6℃ |
| Suʻega D-alpha Tocopherol | ≥25.0% (C29H50O2) | 26.4% |
| Tocopherol fua | ≤1.5% | E usitaia |
| Ta'amilosaga Fa'apitoa | ≥+24.0° | +24.5° |
| Solubility i le Vai | 20g Fa'ata'ita'iga e mafai ona fa'amavae ile 80ml Suavai Fa'apuna | Fa'amama I totonu ole 3 h |
| Acid Value | ≤0.27ml (0.10 N Sodium Hydroxide) | 0.22ml |
| Metala mamafa (Pb) | ≤10ppm | <10ppm |
| Arsenic (As) | ≤1ppm | <1ppm |
| Ta'ita'i | ≤3ppm | <3ppm |
| Mercury (Hg) | ≤0.1ppm | <0.010ppm |
| Solvents totoe | ||
| Ethyl Acetate | ≤50ppm | Le iloa |
| Ethanol | ≤50ppm | 23ppm |
| Faitauga o Papatusi Aofa'i | ≤1000CFU/g | <10CFU/g |
| Faafefete ma Molds | ≤100CFU/g | <10CFU/g |
| Salmonella | Le lelei | Le lelei |
| Escherichia Coli | Le lelei | Le lelei |
| Psendomonas Aeruginosa | Le lelei | Le lelei |
| Staphylococcus Aureus | Le lelei | Le lelei |
| Alaleo Infrared | E tusa ma le Fauga | E usitaia |
| Fa'ai'uga | Ua uma ona fa'ata'ita'iina le oloa ma fa'amalieina fa'atonuga | |
afifi:Fagu, Ato pepa alumini, 25kg/Kati Pusa, pe tusa ai ma manaoga o tagata faatau.
Tulaga teuina:Teu i totonu o se atigipusa tapuni.Teu i totonu o se faleteuoloa malulu, mago (2 ~ 8 ℃) ma fa'alelei lelei mai mea e le fetaui.Puipui mai le malamalama ma le susu.
Va'a:Tu'u atu ile lalolagi atoa ile ea, ile FedEx / DHL Express.Tuuina atu vave ma faatuatuaina tiliva.
FAAMATALAGA
Vitamin E Polyethylene Glycol Succinate o se paluga e faia i le esterification o le d-alpha tocopheryl acid succinate ma polyethylene glycol.O le paluga ester e aofia ai le mono-esterified polyethylene glycol ma sina vaega itiiti o le polyethylene glycol di-esterified.O lo'o iai le NLT 25.0% o le d-alpha tocopherol (C29H50O2).
FAATINOGA
• A. Su'ega Fa'ailoa Fa'ailoaga o le Kesi
Iloiloga: Faʻaauau e pei ona faʻatonuina i le suʻega mo Mataupu o le Alpha Tocopherol.
Ta'iala e talia: O le taimi fa'atumauina o le tumutumu tele o le fa'ata'ita'iga fofo e fetaui ma le vaifofo masani.
FAAFOTOGA
• Anotusi o le Alpha Tocopherol
Solvent: 0.25 mL ole phenolphthalein TS ile 1 L ole ava malosi
Fofo masani ile totonu: 12 mg/mL ole ethyl arachidate ile isooctane
Fofo masani: Fa'aliliu le 32.5 mg o le USP Alpha Tocopherol RS i se fagu tali talafeagai.Faaopopo le 2 mL o le pyridine ma le 0.5 mL o le N,O-bis(trimethylsilyl) trifluoroacetamide ma le 1% trimethylchlorosilane, ma vevela le fagu i le 100 mo le 10 min.Fa'alili le fagu, fa'aopopo le 5.0 mL o le vaifofo masani i totonu ona soso'o ai lea ma le 20 mL o le isooctane, ma lulu.
Fa'ata'ita'iga fofo: Fa'asolo atu se aofa'iga e tutusa ma le 0.100-0.160 g o le Vitamin E Polyethylene Glycol Succinate fa'asusu i le 60 i se fa'agaau fa'aleaganu'u (pe a ma le 20 cm le umi ma le 2.5 cm le lautele) fa'apipi'iina i se pulou sikulima.Faaopoopo i ai le 40–50 mg o le ascorbic acid ma ni nai meata'i pupuna, sosoo ai ma le 20 mL ole Solvent.[Manatua—Fa'asusu le vaifofo ma le lemu e aunoa ma le tu'uina atu o mea o lo'o i totonu.] Tuu le paipa i totonu o se poloka faamafanafana ua seti i le 100–150.A maeʻa le faʻataʻitaʻiga, faʻaopopo le 0.25 g o le potassium hydroxide, ma faʻaauau le reflux mo le 30 min.Ave'ese le fa'agaau mai le vevela, ma a'o vevela pea mea i totonu, fa'aopopo le 1-2 mL o le hydrochloric acid i lalo ifo i lalo seia mou atu le lanu piniki.[Lapataiga—O le tali atu i fafo.Fa'ataga le acid e tafe ifo i totonu o le fa'agaau e taofia ai le sausau.] Fa'alili le paipa, ona fufulu lea o itu o le fa'agaau i le 20 ml vai.Fa'aopoopo le 5.0 mL o le vaifofo masani i totonu, pulou, ma lulu ina ia mautinoa le fa'afefiloi mae'ae'a.Fa'ataga le fa'agaau e tu se'ia o'o ina fa'atūina ni vaega ma'oti se lua.Su'e le 2.5–3.5 mL o le vaega pito i luga i totonu o se fagu tali talafeagai, ma fa'aopopo le 2.0 mL o le pyridine sosoo ai ma le 2.5 mL o le N,O-bis(trimethylsilyl) trifluoroacetamide ma le 1% trimethylchlorosilane.Fa'avela le fagu i le 100 mo le 10 min.Fa'alili, ona fa'aopopo lea o le 12 mL ole isooctane.
Faiga fa'akomepiuta
(Va'ai Chromatography 621, Faiga Fa'atonu.)
Auala: GC
Su'esu'e: Iona afi
Koluma: 0.25-mm × 15-m fused-silica capillary;fa'apipi'i ile ata 0.25-µm ole vaega G27
vevela
Iniseti: 280
Su'esu'e: 345
Koluma: Silasila i le Laulau 1.
Laulau 1
Vevela Muamua(°) Tempera Ramp (°/min) Vevela Mulimuli (°) Taimi Taofi ile Vevela Mulimuli (min)
260 20 340 1
Kesi ave: Helium
Fuafuaga tafe: 1.5 mL/min
Tele tui: 1 µL
Ituaiga tui: Vaeluaga fua faatatau, 200:1
Faiga talafeagai
Fa'ata'ita'iga: Fofo masani
Mana'oga talafeagai
Fa'ailoga fa'ailoga: NMT 2.0 mo le maualuga o le alpha tocopherol
Feso'ota'iga va'aiga: NMT 2.0% mo le fua faatatau o le vaega pito i luga ole alpha tocopherol i le pito i totonu ole pito maualuga.
Iloiloga
Faʻataʻitaʻiga: Fofo masani ma Faʻataʻitaʻiga Fofo
Fa'atatau le pasene o le d-alpha tocopherol (C29H50O2) i le vaega ole Vitamin E Polyethylene Glycol Succinate na ave:
I'uga = (RU/RS) × (WS/WU) × 100
RU = fua faʻatatau i totonu (vaega pito i luga ole alpha tocopherol / pito pito i luga ole tulaga totonu) mai le Sample solution
RS = fua fa'atatau i totonu (vaega pito i luga o le alpha tocopherol / pito pito i luga ole tulaga totonu) mai le vaifofo masani
WS = mamafa o le USP Alpha Tocopherol RS faʻaaogaina e saunia ai le vaifofo masani (mg)
WU = mamafa ole Vitamin E Polyethylene Glycol Succinate ua ave e saunia ai le vaifofo (mg)
Ta'iala e talia: NLT 25.0%
SU'E FA'AMANATU
• Va'aiga Fa'ata'ita'i, Ta'amilosaga Fa'apitoa 781S
[Manatua-O lenei suʻega e iloa ai le d-alpha tocopherol pe a uma le saponification.]
Fa'ata'ita'iga vaifofo: Fa'asolo le 0.9 kalama ole Vitamin E Polyethylene Glycol Succinate, liusuavai ile 60, ise paipa su'esu'e talafeagai e fa'apipi'i i se pulou, ma fa'amuta ile 10.0 mL ole ava malosi.Tuu le paipa i totonu o se poloka faamafanafana ua seti i le 100–105.[Fa'aaliga-Fa'afo'i malie le vaifofo e aunoa ma le fa'aosoina o mea.] A maeʻa le faʻataʻitaʻiga, faʻaopopo 2-3 pellets o le sodium hydroxide, ma faʻaauau le reflux mo se 30 min.Aveese le paipa mai le vevela, ma a'o vevela pea mea i totonu, fa'agata le fa'aogaina o le phenolphthalein e fai ma fa'ailoga e ala i le fa'aopoopo lemu le 10 mL o le fa'afefiloi o le vai ma le hydrochloric acid (1:1) seia mou atu le lanu piniki.[Lapata'iga-Fa'aoso fa'aoso.Fa'ataga le vaifofo oona e tafe ifo i totonu o le fa'agaau e taofia ai le sausau.] Fa'alili le fa'agaau, pulou, ma lulu se'ia fa'afefiloi lelei mea.Faaopopo le 25.0 mL o le heptane, pulou, ma lulu mo le 1 minute ina ia mautinoa le faʻafefiloi maeʻaeʻa.Fa'ataga le fa'agaau e tu se'ia o'o ina fa'atūina ni vaega ma'oti se lua.Fa'afeiloa'i le vaega pito i luga ile faagaau mama matutu, ona fa'aopopo lea ole 10.0 mL ole vai ile vaifofo toe maua.Ufiufi, lulu, ma fa'ataga ona fa'amavae.Fa'afeiloa'i le vaega pito i luga i se paipa mama matutu.Faaopopo le 10.0 mL o le potassium ferricyanide solution, saunia e ala i le faʻamavaeina o le 2 g o le potassium ferricyanide i le 10.0 mL o le 0.2 M sodium hydroxide, ma sui le pulou.Lulu malosi mo le 45 s, ma faʻataga le vaeluaga o le 30 min.Afai e manino le vaega pito i luga o le heptane, faʻaauau le fuaina mo le suiga faʻapitoa;a le manino, fa'agogo i luga ole sodium sulfate a'o le'i fa'aauau le su'ega.[Fa'aaliga-Fa'aaogā fa'ai'uga o le su'ega mo Content of Alpha Tocopherol e fa'atatau le suiga fa'apitoa.]
Tulaga taliaina: NLT +24.0
• Solu i le Vai
Fa'ata'ita'iga: 20 kalama ole Vaitamini E fa'afefeteina Polyethylene Glycol Succinate
Su'esu'ega: Tuu le Fa'ata'ita'i i totonu o se koneteina tioata i luga o se fa'aoso maneta.Fa'aopopo vave le 80 mL o le vai fa'apuna a'o fa'aoso.Fa'ataga e fa'amalie i le vevela o le potu fa'atasi ma le fa'aoso pea.
Tulaga talia: E manino le fofo ile 3 itula.
• Tau Acid
Fa'ata'ita'iga: 1 g ole Vitamin E Polyethylene Glycol Succinate
Su'esu'ega: Fa'amuta le Fa'ata'ita'i ile 25 mL ole fa'afefiloi ole 'ava mālosi ma le eter (1:1) lea ua fa'amuta i le phenolphthalein ile 0.1 N sodium hydroxide.Fa'aopopo le 0.5 mL o le phenolphthalein TS, ma fa'asusu i le 0.10 N sodium hydroxide se'ia tumau pea le lanu piniki le vai pe a uma ona lulu mo le 30 s.
Tulaga talia: NMT 0.027 mEq/g, tutusa ma le NMT 0.27 mL ole 0.10 N sodium hydroxide
FAAOPOOPOGA
• Fa'apipi'i ma Teuina: Fa'asaoina i totonu o atigipusa fufusi, ma teu malu puipuia mai le malamalama.
• Fa'ailoga: O le fa'ailoga o lo'o fa'aalia ai le d-alpha tocopherol, fa'aalia i le mg/g.
• USP Reference Standards 11
USP Alpha Tocopherol RS
Fa'afefea ona Fa'atau?Fa'amolemole fa'afeso'ota'iDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Vitamin E Polyethylene Glycol Succinate (Vitamin E-TPGS; TPGS; Tocofersolan) (CAS: 9002-96-4) o se oloa gaosia.O lo'o maua e pei o le pa'epa'e e o'o i le pa'epa'e samasama waxy Solid ma e toetoe lava leai se tofo.I vaila'au, o se fa'afefiloi e fa'atatau i le monoesterified polyethylene glycol 1000, le polyethylene glycol 1000 diesterified, free polyethylene glycol 1000, ma free tocopherol.
Vitamin E Polyethylene Glycol Succinate ua faʻaaogaina lautele i suʻesuʻega vailaʻau, e pei o se solubilizer, absorption promoter, emulsifier, plasticizer ma le faʻapipiʻiina o le faʻaogaina o vailaʻau e le mafai ona faʻafefeteina poʻo le gaʻo, e pei o le faʻasalalau solo, vaʻavaʻa mo le tuʻuina atu o fualaau oona, ave mo intranasal. tu'uina atu fualaau, ma isi. E fai ma mea'ai fa'aopoopo.
Vitamin E Polyethylene Glycol Succinate o se vai-soluble derivative o vaitamini E, e faia e ala i le taliina o le vaega carboxyl o le vaitamini E succinate ma le hydroxyl vaega o polyethylene glycol.Talu ai ona o loʻo i ai uma vitamini E lipophilic vaega ma polyethylene glycol hydrophilic filifili umi, o loʻo i ai mea lelei faʻafefeteina ma vai solubility, lea e mafai ona matua faateleina ai le absorption o fualaau faasaina i le gastrointestinal tract, faateleina bioavailability.
I tausaga talu ai nei, o le tele o suʻesuʻega ua maua ai le TPGS e le gata e mafai ona faʻaaogaina e avea ma vailaʻau faʻapitoa, ae e tele foʻi uiga faʻapitoa, e pei o le faʻaleleia o le absorption ma le tele o vailaʻau faʻalavelave faʻafefe, e mafai foi ona faʻaaogaina le TPGS i prodrugs, micelles, liposomes, TPGS-copolymer. ave e faʻaleleia le solubility, permeability ma le mautu o le sauniuniga, ina ia ausia lemu, faʻasaʻo faʻasaʻo ma le faʻamoemoeina o aʻafiaga, faʻaleleia le faʻaaogaina o fualaau.
1. Pharmaceutical - Vitamin E-TPGS e matua faʻaleleia atili ai le faʻaogaina, bioavailability ma le aoga o vailaʻau vailaʻau (APIs)
2. Mea'ai fa'aopoopo - Vitamin E-TPGS e fa'aaogaina e fai ai mea fa'aopoopo, ae maise lava na mea na faia e fa'aleleia atili ai le su'esu'eina ole vaitamini E ma isi mea'ai lipophilic ma nutraceuticals.
3. Mea'ai ma Meainu - Vitamin E-TPGS e mafai ona fa'aaogaina e fa'amalosia ai mea'ai ma meainu, meainu ta'aloga, vai ma sua.
4. Tausiga a le Tagata Lava Ia - Vitamin E-TPGS e avea o se ethanol e leai se totogi, hypoallergenic, e le fa'afefeteina emulsifier/excipient i le tausiga o le tagata lava ia ma fa'aoga teuteu.
5. Mea'ai Mea'ai a Manu - Vitamini E-TPGS o lo'o tu'uina mai ai se vaitamini E sili ona mafai ona fa'amama ma olaola mo manu e le mafai ona fa'amalieina tu'aiga masani ole vaitamini E.
Vitamini E polyethylene glycol succinate ose vaitamini Esterified (tocopherol) fa'aaoga muamua e avea o se solubilizer po'o se emulsifying agent ona o ona meatotino surfactant.I le faʻatulagaina, o le amphipathic ma le hydrophilic, e le pei o le tocopherols, ma o le mea lea o se vai-soluble derivative lea e mafai ona faʻaaogaina i vailaʻau faʻapitoa e pei o capsules, tablets, extrusion vevela, microemulsions, oloa autu, ma matua.O se tasi o faʻaoga sili ona taua o lona faʻaaogaina o se taʻavale mo le faʻaogaina o vailaʻau faʻavae lipid.E mafai foi ona faʻaaogaina e fai ma puna o vaitamini E. Vitamin E polyethylene glycol succinate ua faʻaalia e tusa ai ma lona faiga o gaioiga ma suʻesuʻeina e avea o se inhibitor Pglycoprotein.
Vitamin E polyethylene glycol succinate e le fetaui ma acids malosi ma alkalis malosi.
lisi GRAS.E aofia i le FDA Inactive Ingredients Database (fofo ophthalmic po'o matau'a; capsules tu'u gutu, vaifofo, laulau; fofo autu po'o matau'a).O lo'o aofia i le Lisi a Kanata o mea'ai e le o ni vaila'au e talia.
