Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2 API Tulaga Maualuga
Tuuina atu le Vonoprazan Fumarate ma le Intermediate Intermediate
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Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Igoa Vailaau | Vonoprazan Fumarate |
| Synonyms | TAK-438 |
| Numera CAS | 1260141-27-2;881681-01-2 |
| CAT Numera | RF-API99 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
| Fuafua mole | C21H20FN3O6S |
| Molecular Weight | 461.463 |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e pe Toeitiiti-Pa'epa'e Pa'u tioata |
| Fa'ailoa 1 H-NMR | Ia ogatasi ma le Fa'atonu |
| Faailoaina IR | Ole alaleo ole IR Absorption ole fa'ata'ita'iga e fetaui ma tulaga fa'asino |
| Fa'ailoga HPLC | Le taimi fa'atumauina o le fa'ata'ita'iga e fa'atatau i tulaga fa'asino |
| Suavai Suavai | ≤0.50% |
| Toega i luga o le mumu | ≤0.20% |
| Metala mamafa (pei o le Pb) | ≤20ppm |
| Mea Fa'atatau | |
| Le mama A | ≤0.20% |
| Le mama B | ≤0.15% |
| Le mama C | ≤0.15% |
| So'o se isi mea le mama | ≤0.10% |
| Aofa'i Fa'aleaga | ≤1.0% |
| Solvents totoe | |
| Methanol | ≤0.30% |
| Ethanol | ≤0.50% |
| Ethyl Acetate | ≤0.50% |
| Su'ega / Su'esu'ega Metotia | 98.0%~102.0% (E le HPLC) |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | API |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu.
Vonoprazan Fumurate (TAK-438) (CAS: 1260141-27-2; 881681-01-2), o se faʻatoʻaga pamu (PPI), o se vailaʻau malosi faʻatauvaʻa faʻatauvaʻa (P-CAB), faʻatasi ai ma antisecretory. gaoioiga.Vonoprazan Fumarate faʻalavelaveina le H +, K + -ATPase gaioiga i porcine gastric microsomes ma le IC50 o le 19 nM ile pH 6.5.Vonoprazan Fumarate (Takecab), maua ma atiina ae e Takeda ma Otsuka, na faamaonia e le PMDA o Iapani ia Tesema 2014. Vonoprazan Fumarate e masani ona faʻaaogaina mo togafitiga o le helicobacter pylori faʻamaʻi, gastroesophageal reflux, peptic ulcer, duodenal ulcer, esophagitis, gastric papala ma isi fa'ama'i e feso'otai i le ga'o.O le oloa o lo'o i ai se malosi, fa'agata tumau o le fa'alilo o le gatric acid.I le fua o togafitiga, o Vonoprazan Fumarate e itiiti sona a'afiaga i isi enzymes ma e itiiti sona a'afiaga i galuega fa'aletino o le tino.E saogalemu ma sili atu ona gafatia.
