Zoledronic Acid CAS 118072-93-8 Mama ≥99.7% API Falegaosi Tulaga Maualuga
Tuuina atu ma le mama maualuga ma le mautu lelei
Igoa Vailaau: Zoledronic Acid
CAS: 118072-93-8
Mamana Farnesyl Diphosphate (FPP) Synthase Inhibitor
API Tulaga Maualuga, Gaosiga Fa'apisinisi
| Igoa Vailaau | Zoledronic Acid |
| Synonyms | ZOL 446, ZA, Zoledronate, CGP-4244, GP42446A, Zometa, Zomera;[1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid |
| Numera CAS | 118072-93-8 |
| CAT Numera | RF-API90 |
| Tulaga Fa'asoa | I Fa'atauga, Oloa Fua e O'o i le selau Kilograms |
| Fuafua mole | C5H10N2O7P2 |
| Molecular Weight | 272.09 |
| Lisi Lisi | 193.0~204.0 ℃ |
| Fa'ailoga | Ruifu Chemical |
| Aitema | Fa'amatalaga |
| Fa'aaliga | Pa'epa'e i le Pa'u Pa'epa'e Pa'epa'e |
| Fa'ailoaga | IR Spectrum o le faʻataʻitaʻiga e fetaui ma le tulaga o faʻamatalaga |
| pH | 2.0~4.0 |
| Solubility | Fa'ase'e solu i le 0.1N Sodium Hydroxide Solution, La'ititi Solu i le Suavai ma le 0.1N Hydrochloric Acid, E le mafai ona solu ile Ethanol. |
| Mea Fa'atatau | |
| So'o se Fa'aleaga Ta'ito'atasi | ≤0.10% |
| Aofa'i Fa'aleaga | ≤0.30% |
| Ma'imau ile Fa'amago | 5.0%~7.0% |
| Klorida | ≤0.02% |
| Phosphite | ≤0.50% |
| Phosphate | ≤0.50% |
| Metala mamafa | ≤10ppm |
| Mama | ≥99.7% |
| Tulaga Su'ega | Pisinisi Tulaga |
| Fa'aoga | API, FPP Synthase Inhibitor, Hypercalcemia of Malignancy (HCM) |
afifi: Fagu, taga pepa alumini, pusa pepa, 25kg / Paʻu, poʻo le tusa ai ma manaʻoga o tagata faʻatau.
Tulaga teuina:Teu i totonu o pusa faʻamaufaʻailoga i se nofoaga malulu ma mago;Puipui mai le malamalama, susu ma le afaina o meaola faalafua.
O le Zoledronic Acid (CAS 118072-93-8) o se fa'amalosi malosi o le bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50=20 nM).Fa'alavelaveina le fa'aosoina o ponaivi fa'atasi o le osteoclast.E taofia foi le fa'ailoga Ras ma le tuputupu a'e o le tuma, ma fa'aoso apoptosis i sela o le kanesa pancreatic.Fa'aliliuina le suiga o le epithelial-mesenchymal ma fa'alavelaveina le fa'afouina o sela o le kanesa o le susu e ala i le fa'agataina o le NF-κB.O le Zoledronic acid na faʻamaonia e le US FDA i le 2001 mo le togafitia o le hypercalcemia o le maʻi, o se faʻalavelave faʻalavelave e ono lamatia ai le ola.Ole Hypercalcemia ole fa'ama'i e mafai ona tupu ile 50% o tagata mama'i e maua ile kanesa o le susu, tele myeloma, ma le kanesa ole mama sela laiti.E alia'e lea tulaga pe a o'o ina fa'atupuina e le tuma e mafua ai le fa'aosoina o osteoclasts.A fa'atupula'ia le fa'aleagaina o ponaivi, o lo'o i ai le tu'u fa'atasi o le calcium i totonu o le plasma.Pe a vave ona si'itia le toto o le calcium, e le mafai e fatuga'o ona taulimaina le mamafa, ma maua ai le hypercalcemia.O le vaila'au Zoledronic e fa'aitiitia lelei le fa'atupuina o le calcium plasma e ala i le taofia o le toe fa'aleleia o ponaivi (fa'alavelaveina o gaioiga o le osteoclastic ma le fa'aosoina o le apoptosis o le osteoclast).E le gata i lea, o le zoledronic acid ua fa'amaonia e le US FDA mo le togafitia o le tele o myeloma ma ponaivi metastases e feso'ota'i ma kanesa e fa'atatau i le tuma (fa'ata'ita'iga, fa'apa'u ma mama).
