2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5 Kuchena ≥98.0% Olaparib Intermediate Factory
High Purity, Commercial Production
Olaparib uye Inoenderana Nepakati:
Olaparib CAS 763113-22-0
2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid CAS 763114-26-7
1-(Cyclopropylcarbonyl)piperazine Hydrochloride CAS 1021298-67-8
3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9
| Chemical Name | 2-Fluoro-5-Formylbenzonitrile |
| Mashoko anoreva zvakafanana | 3-Cyano-4-Fluorobenzaldehyde |
| Nhamba yeCAS | 218301-22-5 |
| Nhamba yeCAT | RF-PI451 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
| Molecular Formula | C8H4FNO |
| Molecular Weight | 149.12 |
| Melting Point | 80.0 kusvika 84.0 ℃ (lit.) |
| Solubility | Soluble muMethanol |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Yero kune Off-white Powder |
| Kuchena | ≥98.0% |
| Kunyorova (KF) | ≤0.50% |
| Zvose Zvisina Kuchena | ≤2.0% |
| Test Standard | Enterprise Standard |
| Usage | Pakati peOlaparib (CAS: 763113-22-0) PARP-Inhibitor |
Package: Bhodhoro, Aluminium foil bag, Cardboard Drum, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro.
2-Fluoro-5-Formylbenzonitrile (CAS: 218301-22-5) inoshandiswa mukugadzirira heterocyclic compounds sePARP inhibitors yekushandiswa kwechiremba.2-Fluoro-5-Formylbenzonitrile inoshandiswa sepakati peOlaparib (CAS: 763113-22-0).Olaparib idiki molecule inhibitor yePARP1/PARP2 (IC50: 5/1 nM) asi isinganyanyi kushanda paPARP tankyrase-1 (IC50: 1.5 µM).Olaparib (AZD-2281, zita rekutengesa Lynparza) chirongwa chakatenderwa neFDA-chakanangana nekurapa cancer, chakagadzirwa neKuDOS Pharmaceuticals uye gare gare neAstraZeneca.IPARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), enzyme inobatanidzwa mukugadzirisa DNA. Inorwisa kenza muvanhu vane nhaka yeBRCA1 kana BRCA2 mutations, iyo inosanganisira mamwe ovarian, mazamu, uye prostate cancer.Muna Zvita 2014, olaparib yakatenderwa kushandiswa semumiriri mumwechete neEMA neFDA.Mvumo yeFDA ndeye germline BRCA yakashandurwa (gBRCAm) kenza yepamusoro ye ovarian iyo yakagamuchira mitsara mitatu kana kupfuura yapfuura yechemotherapy.
