3-Nitrophthalic Anhydride CAS 641-70-3 Pomalidomide Intermediate Purity > 98.0% (HPLC)
Ruifu Chemical ndiyo inotungamira kugadzira 3-Nitrophthalic Anhydride (CAS: 641-70-3) ine mhando yepamusoro, yepakati yePomalidomide (CAS: 19171-19-8).Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga 3-Nitrophthalic Anhydride,Please contact: alvin@ruifuchem.com
| Chemical Name | 3-Nitrophthalic Anhydride |
| Mashoko anoreva zvakafanana | 3-Nitrophthalic Acid Anhydride;4-Nitro-2-Benzofuran-1,3-Dione;4-Nitroisobenzofuran-1,3-Dione;4-Nitro-1,3-isobenzofurandione;Pomalidomide Impurity A |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 641-70-3 |
| Molecular Formula | C8H3NO5 |
| Molecular Weight | 193.11 g/mol |
| Melting Point | 161.0 kusvika 165.0 ℃ |
| Sensitive | Hunyoro Inonzwa |
| Mvura Solubility | Inogona Kuora Mumvura |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Yero Yero kusvika Yero Yetsono Crystal kana Crystalline Powder | Zvinoenderana |
| Melting Point | 161.0~165.0℃ | 163.0~165.0℃ |
| Kurasika paKuomesa | <0.50% | 0.10% |
| Kuchena / Analysis Method | >98.0% (HPLC) | 98.85% |
| Infrared Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| 1H NMR Spectrum | Zvinoenderana NeChimiro | Zvinoenderana |
| Mhedziso | Chigadzirwa chakaedzwa uye chinoenderana nezvakapihwa | |
| Application | Pakati pePomalidomide (CAS: 19171-19-8) | |
Package:Fluorinated Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Air sensitive.Chengetedza mudziyo wakavharwa zvakasimba uye chengeta muimba inotonhorera, yakaoma uye ine mhepo yakanaka kure nezvinhu zvisingaenderani.Ramba kure nezuva;dzivisa moto;dzivisa unyoro.Ramba kure neoxidizing agents.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Hazard Symbols Xi - Irritant
Risk Codes
36/37/38 - Kushungurudza maziso, kufema system uye ganda.
Tsanangudzo Yekuchengetedza
S26 - Kana wasangana nemaziso, simbura nekukasira nemvura yakawanda uye tsvaga mazano ekurapwa.
S36 - Pfeka zvipfeko zvinodzivirira zvakakodzera.
S37/39 - Pfeka magirovhosi akakodzera uye dziviriro yeziso / kumeso
WGK Germany 3
FLUKA BRAND F CODES 10-21
TSCA Hongu
HS Code 2917399090
3-Nitrophthalic Anhydride (CAS: 641-70-3) inoshandiswa sepakati pePomalidomide (CAS: 19171-19-8).Muna Kukadzi 2013, US FDA yakabvumidza Pomalidomide kurapwa kweakawanda myeloma (MM) muvarwere vane chirwere chekuwedzera mushure mekugamuchira mamwe marapirwo egomarara.Pomalidomide inonzi 4-amino analog yethalidomide ine simba rinowedzera uye yakagadziridzwa chepfu.Pomalidomide uye thalidomide zvinoshandisa migumisiro yazvo kuburikidza nekugadzirisa hutachiona, inhibition ye angiogenesis, kupindira nefupa / bundu microenvironment, uye kuvharidzirwa kweprotein yecereblon.Pomalidomide zvine simba inhibited in vitro proliferation mumhando dzakasiyana dzeMM cell mitsara, IC50 ~ 10 nM, nepo thalidomide yakaratidza kunenge isina inhibition kusvika ku100 μM.Mune mbeva yeMM tumor modhi, 50 mg/kg zuva nezuva dosi yepomalidomide yakakonzera kuvharidzirwa kwebundu kukura mushure memazuva gumi nemashanu ekurapwa uye kudzoreredza kuzere mumavhiki 3-6 maringe nekudzora thalidomide-yakarapwa panguva imwecheteyo.Pomalidomide inogadzirwa ne condensation ye 3-Nitrophthalic Anhydride ne 3-Aminopiperidine-2,6-Dione inoteverwa necatalytic hydrogenation yeboka re nitro.
