Afatinib CAS 439081-18-2 Kuchena > 99.5% (HPLC) Factory

Tsanangudzo Pfupi

Zita reKemikari: Afatinib

Anoreva zvakafanana: BIBW2992

CAS: 439081-18-2

Kuchena:> 99.5% (HPLC)

Chitarisiko: Off-White Powder

E-Mail: alvin@ruifuchem.com

Tumira email kwatiri

Product Detail

Product Tags

Tsanangudzo:

Ruifu Chemical Supply Intermediates yeAfatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-imwe CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Chemical Name	Afatinib
Mashoko anoreva zvakafanana	BIBW2992;BIBW-2992;BIBW2992 Free Base;Tomtovok;(S,E)-N-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(Dimethylamino)asi-2-Enamide
Nhamba yeCAS	439081-18-2
Nhamba yeCAT	RF-PI2033
Stock Status	MuStock, Kugadzirwa Kunokwira Kusvika Matani
Molecular Formula	C24H25ClFN5O3
Molecular Weight	485.94
Solubility	Soluble muDMSO
Density	1.380
Brand	Ruifu Chemical

Zvinotsanangurwa:

Item	Zvinotsanangurwa
Chitarisiko	Off-White Powder
Identification	HPLC, NMR
Kuchena / Analysis Method	>99.5% (HPLC)
Melting Point	100.0 ~ 102.0 ℃
Kurasika paKuomesa	<0.50%
Residue paIgnition	<0.20%
Zvose Zvisina Kuchena	<0.50%
Heavy Metals	≤20ppm
NMR Spectrum	Inopindirana neChimiro
Test Standard	Enterprise Standard
Sherufu Hupenyu	Mwedzi 24 Kana Yakachengetwa Zvakanaka
Usage	API;Afatinib;Afatinib Dimaleate;NSCLC

Package & Kuchengeta:

Package: Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.

Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro

Zvakanakira:

FAQ:

Application:

Afatinib, inozivikanwawo seBIW-2992, (CAS: 439081-18-2) chizvarwa chechipiri chine simba uye chisingachinjiki chechipiri inhibitor ye epidermal growth factor receptor (EGFR) uye epidermal kukura factor receptor 2 (HER2) tyrosine kinase, yakagadzirwa naBoehringer Ingelheim, Germany.Iyo inokwanisa kuvharidzira zvisingachinjiki basa re tyrosine kinase kuburikidza nekuita Michael reaction ne thiol group ye cysteine panzvimbo 797 yeEGFR.Musi waChikunguru 12, 2013, yakava mushonga mutsva wekurwisa-diki kenza yemapapu yakabvumidzwa neUS FDA pasi pezita rekutengesa reGilotrif.Mushonga uyu piritsi.Inoshandiswa kurapwa kwevarwere vakawanikwa vaine metastatic isiri-diki cell cell cancer cancer (NSCLC) nekurasikirwa kwe19th exon kana L858R mutation mu21th exon ye tumor epidermal growth factor receptor (EGFR) yakasimbiswa uchishandisa kit yakabvumidzwa. neFDA.Mushonga uyu unoshandawo mukurapa kweHER2-positive varwere vane kenza yemazamu yepamusoro.Afatinib ndeyekirasi yemishonga inozivikanwa se tyrosine kinase inhibitors.Tyrosine kinase inhibitors yakagadzirirwa kuvharidzira kuita kweiyo enzyme inonzi tyrosine kinase.Iyi enzyme inoita basa guru mukushanda kwemaseru, uye inoshanda mukusimudzira kukura kwebundu uye kufambira mberi.Afatinib inoshanda kuvharidzira kushanda kwemhando mbiri dzetyrosine kinases: epidermal growth factor receptor (EGFR) uye Her2, iyo "inoratidzirwa" nemhando dzakawanda dzekenza.Nekuvhara basa reiyi tyrosine kinases, Afatinib inogona kudzivirira cancer maseru kubva kupatsanura nekukura.