Afatinib Dimaleate CAS 850140-73-7 Kuchena >99.5% (HPLC) API Featured Image

Purogiramu inonzi Afatinib Dimaleate CAS 850140-73-7 Purity >99.5% (HPLC)

Tsanangudzo Pfupi

Zita reKemikari: Afatinib Dimaleate

Anoreva zvakafanana: BIBW2992 Dimaleate

CAS: 850140-73-7

Kuchena:> 99.0% (HPLC)

Chitarisiko: Muchena kusvika Kuchena-Upfu

API High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com

Tumira email kwatiri

Product Detail

Product Tags

Tsanangudzo:

Ruifu Chemical Supply Intermediates yeAfatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-imwe CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Chemical Name	Afatinib Dimaleate
Mashoko anoreva zvakafanana	BIBW2992 Dimaleate;(S,E)-N-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)asi-2-Enamide Dimaleate
Nhamba yeCAS	618-89-3
Nhamba yeCAT	RF-PI2032
Stock Status	MuStock, Kugadzirwa Kunokwira Kusvika Matani
Molecular Formula	C32H33ClFN5O11
Molecular Weight	718.08
Sensitivity	Hunyoro Inonzwa
Brand	Ruifu Chemical

Zvinotsanangurwa:

Item	Zvinotsanangurwa
Chitarisiko	Ichena kusvika kuOff-White Powder
Kuchena / Analysis Method	>99.5% (HPLC)
Kurasika paKuomesa	<0.50%
Residue paIgnition	<0.10%
Maximum Single Kusachena	<0.30%
Zvose Zvisina Kuchena	<0.50%
Heavy Metals (as Pb)	≤20ppm
Infrared Spectrum	Inopindirana neChimiro
NMR	Inopindirana neChimiro
Test Standard	Enterprise Standard
Sherufu Hupenyu	Mwedzi 24 Kana Yakachengetwa Zvakanaka
Usage	API

Package & Kuchengeta:

Package: Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.

Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro

Zvakanakira:

FAQ:

Application:

Afatinib Dimaleate (CAS: 850140-73-7), iyo dimaleate munyu fomu yeafanitib, inowanikwa nemuromo antineoplastic agent.Afatinib Dimaleate is irreversible EGFR family inhibitor ine IC50s ye0.5 nM, 0.4 nM, 10 nM uye 14 nM yeEGFRwt, EGFRL858R, EGFRL858R/T790M uye HER2, zvichiteerana.Afatinib Dimaleate inoratidzwa kune yekutanga-mutsara kurapwa kwevarwere vane metastatic isiri-diki cell kenza yemapapu (NSCLC) vane mapundu ane epidermal growth factor receptor (EGFR) exon 19 deletions kana exon 21 (L858R) inotsiva shanduko sezvaonekwa neFDA- bvunzo dzakabvumidzwa.Kare, kurapwa kwakajairwa neplatinum-based chemotherapy doublet regimen yaionekwa seyakajairwa mutsara wekutanga kurapwa kune vese varwere vane NSCLC.Nekudaro, humbowo huri kubuda hwakaratidza madiki umo kurapa kwakanangwa kunoshanda zvakanyanya, zvichitungamira mukugadzirwa kwemishonga-yakanangana nekuchinja.Afatinib Dimaleate Yakagadzirwa naBoehringer Ingelheim Pharmaceuticals, Afatinib Dimaleate yakabvumidzwa neFDA muna 2013 semushonga wenherera pasi pezita rekutengesa Gilotrif.Afatinib Dimaleate inogadzirwa nemakemikari uchishandisa yakajairwa nzira.Afatinib Dimaleatehaisi kungoshanda chete kupesana neEGFR kuchinja kunotarirwa nechizvarwa chekutanga TKIs se erlotinib kana gefitinib, asiwo kurwisana nekuchinja kwakafanana neT790M iyo isinganzwisisi kune aya maitiro ekurapa.Nekuda kwebasa rayo rekuwedzera kurwisa Her2, iri kuongororwa gomarara rezamu pamwe nemamwe EGFR uye Her2 inofambiswa negomarara.