Afatinib Dimaleate Yepakati CAS 314771-76-1 Kuchena > 99.0% (HPLC) Factory

Tsanangudzo Pfupi:

Kemikari Zita: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1

Kuchena:> 99.0% (HPLC)

Chitarisiko: Yero Yero kusvika Yero Upfu

Pakati peAfatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Tumira email kwatiri

Product Detail

Product Tags

Tsanangudzo:

Ruifu Chemical Supply Intermediates yeAfatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-imwe CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Chemical Name	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine
Mashoko anoreva zvakafanana	N4-(3-Chloro-4-Fluorophenyl) -7-[[(3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine;Afatinib Kusachena B;Afatinib-des(4-Dimethylamino-2-en-1-oxo)butyl;Des(4-Dimethylamino-2-en-1-oxo)butyl Afatinib
Nhamba yeCAS	314771-76-1
Nhamba yeCAT	RF-PI2028
Stock Status	MuStock, Kugadzira Kugona 100MT/Gore
Molecular Formula	C18H16ClFN4O2
Molecular Weight	374.8
Boiling Point	559.0±50.0℃
Density	1.473±0.060 g/cm3
Brand	Ruifu Chemical

Zvinotsanangurwa:

Item	Zvinotsanangurwa
Chitarisiko	Yero Yero kusvika Yero Hupfu
Identification	Iyo Nguva Yekuchengeta YePrincipal Peak muHPLC Inofanirwa Kuenderana neChiyero
Kuchena / Analysis Method	>99.0% (HPLC)
Kurasika paKuomesa	<0.50%
Residue paIgnition	<0.20%
Kusachena Kumwechete	<0.50%
Zvose Zvisina Kuchena	<1.00%
Heavy Metals (as Pb)	≤20ppm
Test Standard	Enterprise Standard
Usage	Pakati peAfatinib Dimaleate (CAS: 850140-73-7)

Package & Kuchengeta:

Package: Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.

Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro

Zvakanakira:

FAQ:

Application:

(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) iri pakati peAfatinib Dimaleate. (CAS: 850140-73-7).Afatinib chizvarwa chechipiri chine simba uye chisingachinjiki chechipiri inhibitor ye epidermal growth factor receptor (EGFR) uye epidermal growth factor receptor 2 (HER2) tyrosine kinase, yakagadzirwa naBoehringer Ingelheim, Germany.Iyo inokwanisa kuvharidzira zvisingachinjiki basa re tyrosine kinase kuburikidza nekuita Michael reaction ne thiol group ye cysteine panzvimbo 797 yeEGFR.Basa: 1. Kufanana neLapatinib neNeratinib, Afatinib iprotein kinase inhibitor iyo inodzivisawo irreversibly inhibits epidermal growth factor receptor 2 (Her2) uye epidermal growth factor receptor (EGFR) kinases.2. Afatinib haisi kungoshanda chete kurwisana neEGFR kuchinja kunotarirwa nevekutanga veTKIs se erlotinib kana gefitinib, asiwo kunopesana nekuchinja kwakafanana neT790M iyo isinganzwisisi kune aya maitiro ekurapa.Nekuda kwebasa rayo rekuwedzera kurwisa Her2, iri kuongororwa gomarara rezamu pamwe nemamwe EGFR uye Her2 inofambiswa negomarara.3. Afatinib mushonga wekurapa mutsara wekutanga wevarwere vane mhando dzakasiyana dze metastatic (EGFR mutation positive) isiri-small cell lung carcinoma (NSCLC).Inoshanda sechinhu chisingachinjiki covalent inhibitor ye receptor tyrosine kinases epidermal growth factor receptor (EGFR) uye erbB-2 (HER2).