Anastrozole CAS 120511-73-1 API Factory High Quality
Mugadziri Wekutengesa ane Kuchena Kwepamusoro uye Hunhu Hwakagadzikana
Kemikari Zita: Anastrozole
CAS: 120511-73-1
Zita | Anastrozole |
Mashoko anoreva zvakafanana | Arimidex;α,α,α',α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl) -1,3-benzenediacetonitrile |
Nhamba yeCAS | 120511-73-1 |
Nhamba yeCAT | RF-API74 |
Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Mazana emaKilogram |
Molecular Formula | C17H19N5 |
Molecular Weight | 293.37 |
Solubility | Soluble muDMSO uye Ethanol |
Brand | Ruifu Chemical |
Item | Zvinotsanangurwa |
Chitarisiko | Ichena kusvika kuOff-White Crystalline Powder |
Identification A | IR/MS Inopindirana nereferensi chiyero |
Kuzivikanwa B | HPLC uye peak chimiro: Inoenderana nereferensi |
Melting Point | 81.0~84.0℃ |
Mvura Yemukati (neKF) | ≤0.30% |
Residue paIgnition | ≤0.10% |
Kurasika paKuomesa | ≤0.50% |
Heavy Metals | ≤10ppm |
Related Substances | |
Kusachena A | ≤0.10% |
Kusachena B | ≤0.20% |
Kusachena C | ≤0.20% |
Kusachena D | ≤0.10% |
Kusachena E | ≤0.10% |
Single Other Kusachena | ≤0.10% |
Zvose Zvisina Kuchena | ≤0.50% |
Residual Solvents | |
Cyclohexane | ≤0.30% |
Ethyl Acetate | ≤0.50% |
Assay | 98.0% ~ 102.0% (pane yakaomeswa) |
Sherufu Hupenyu | 24 Mwedzi |
Test Standard | Enterprise Standard;United States Pharmacopoeia (USP) Standard |
Usage | Kurapa Gomarara Repazamu |
Package: Bhodhoro, Aluminium foil bag, Cardboard dhiramu, 25kg/Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza, mwando uye tumbuyu.
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Anastrozole (CAS 120511-73-1), isiri-steroidal, yechitatu-chizvarwa achiral triazole derivative inotengeswa seARIMIDEX® neAstraZeneca Pharmaceuticals LP1.Icho chimwe chechitatu-chizvarwa aromatase inhibitor iyo inonyanya kukwikwidza uye inosarudza inhibitor ye aromatase, nokudaro ichivhara kutendeuka kwe testosterone mu estradiol uye androstenedione mu estrone.Kudzivirirwa kwearomatase enzyme kunoitika kunyanya kuburikidza nemakwikwi ekusunga kwearomatase kune hemegroup ye cytochrome P450, kuderera kweesrogen biosynthesis mumativi emuviri uye muzamu.
Anastrozole mushonga unowanzo bvumidzwa kurapa kenza yemazamu yekutanga.Kufanana nemamwe aromatase inhibitors, iyo inonyanya kukosha yakashata yaive njodzi yakawedzera yekutyoka kwemapfupa, iyo yeanastrozole yaingogumira panguva yekurapa.Iyo ine hunhu ine huturu hunyoro kana ichienzaniswa nechemotherapy;zvisinei, zvakaonekwa kuti varwere vakawanda vanorapwa neanastrozole vakanyunyuta pamusoro pezviratidzo zvekubatana pane zvaitarisirwa, kunyanya kuoma kwedhijitari kwakafanana neiyo yerheumatoid arthritis.Mimwe miedzo yekiriniki yeanastrozole yevakadzi mushure mekuenda kumwedzi vane kenza yemazamu muEurope uye United States yakashuma kusagadzikana kwemusculoskeletal sezviitiko zvakashata.Anastrozole (Arimidex®) is aromatase inhibitor yakatenderwa muEU, US uye kune dzimwe nyika pasi rese kuti ishandiswe seadjuvant kurapwa muvakadzi vepashure memenopausal vane danho rekutanga, hormone receptor-positive kenza yemazamu.Inotenderwa zvakare muEU nedzimwe nyika pasi rese kuti ienderere mberi nekurapa adjuvant muvakadzi vanga vatove nemakore 2-3 e-adjuvant tamoxifen kurapwa kwegomarara rezamu.
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