Apixaban CAS 503612-47-3 Kuchena ≥99.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira kugadzira Apixaban (CAS: 503612-47-3) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Apixaban,Please contact: alvin@ruifuchem.com
| Chemical Name | Apixaban |
| Mashoko anoreva zvakafanana | 1-(4-Methoxyphenyl) -7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine -3-carboxamide, 4,5,6,7-Tetrahydro-1- (4-methoxyphenyl) -7-oxo-6-[4-(2-oxo-1-piperidinyl) phenyl] -1H-pyrazolo[3, 4-c]pyridine-3-carboxamide, BMS 562247, BMS-562247 |
| Stock Status | MuStock, Commercial Production |
| Nhamba yeCAS | 503612-47-3 |
| Molecular Formula | C25H25N5O4 |
| Molecular Weight | 459.51 g/mol |
| Melting Point | 235.0~238.0℃ |
| Density | 1.42 |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Category | API |
| Brand | Ruifu Chemical |
| Items | Kuongorora Maitiro | Results |
| Chitarisiko | Ichena kusvika kuOff-White Crystalline Powder | Zvinoenderana |
| Kurasika paKuomesa | ≤0.50% | 0.10% |
| Residue paIgnition | ≤0.10% | 0.08% |
| Heavy Metals (as Pb) | ≤20ppm | Zvinoenderana |
| Related Substances | ||
| Chero Kusachena Kumwe | ≤0.50% | Zvinoenderana |
| Zvose Zvisina Kuchena | ≤0.50% | Zvinoenderana |
| Kuchena / Analysis Method | ≥99.5% (HPLC) | 99.9% |
| Infrared Spectrum | Inopindirana neChimiro | Zvinoenderana |
| 1 H NMR Spectrum | Inopindirana neChimiro | Zvinoenderana |
| Mhedziso | Chigadzirwa chacho chakaedzwa uye chinoenderana nezvinodiwa | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Hapana chimwe chezvigadzirwa chichapihwa kunyika umo izvi zvinogona kunge zvichipesana nezviripo patents.Zvisinei basa rekupedzisira riri pamutengi.
Kutsvagisa kwesainzi shandisa chete, kwete kune chero chinangwa chekutengesa, kwete chekushandisa kwevanhu kana kuongororwa.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Apixaban (CAS: 503612-47-3) inzira itsva yemuromo anticoagulant drug yakagadzirwa naBristol Myers Squibb uye Pfizer.Iyo imhando nyowani yemuromo Xa factor inhibitor, uye zita rayo rekutengesa ndiEliquis.Apixaban inoshandiswa kurapa varwere vakuru vari kusarudzwa hudyu kana kutsiva mabvi kuvhiyiwa kudzivirira venous thromboembolism (VTE)
Apixaban (CAS: 503612-47-3) is oral selective activated Xa factor inhibitor uye inogona kudzivirira thrombin chizvarwa uye thrombosis.
Apixaban (CAS: 503612-47-3) ndiyo yechitatu itsva oral anticoagulant kuenda kutengeswa, ichitevera dabigatran uye rivaroxaban, uye yakatotenderwa muEurope kudzivirira venous thromboembolism muvarwere vari kusarudzwa hudyu kana kutsiva mabvi.Kunze kweaya matatu emuromo anticoagulants anotenderwa muEurope, zvichienzaniswa neazvino chiyero chekudzivirira kurapwa kurwisa venous thromboembolism, enoxaparin, rivaroxaban yakakunda muyedzo yekurekodha, uye apixaban yakakunda mukuyedza kwepamberi.Rivaroxaban's kurapa mhedzisiro yaive yepamusoro zvishoma, asi yakakonzera kubuda ropa kwakanyanya kupfuura apixaban.Vatsvakurudzi vakataura kuti kusiyana uku kune nguva yemishonga, sezvo rivaroxaban yakatorwa maawa 6-8 mushure mekuvhiyiwa mukuedzwa kwerekodhi, nepo apixaban yakashandiswa maawa 18 mushure mekuvhiyiwa mukuedza kwepamberi.Mishonga iyi ine kurapa kurinani kana ikashandiswa padyo nenguva yekuvhiyiwa, asi zvakare ine njodzi yekubuda ropa.Ongororo yekiriniki yakaratidza kuti kana ichienzaniswa nejekiseni remazuva ese re40mg enoxaparin, 2 oral 2.5mg dosages yeapixaban yaive nekudzivirira zvirinani kurwisa venous thromboembolism zvichitevera kuvhiyiwa kwehudyu kana mabvi uye haina kuwedzera njodzi yekubuda ropa.
Apixaban (CAS: 503612-47-3) rudzi rutsva rwemuromo Xa factor inhibitor yakabatanidzwa yakagadzirwa neBristol-Myers Squibb uye Pfizer.Zita rekutengesa ndiro eratol, inova rudzi rutsva rwemuromo anticoagulant.Nekudzivisa yakakosha coagulation factor Xa, apixaban inogona kudzivirira thrombin kugadzirwa uye thrombosis.Musi waKubvumbi 26, 2007, Bristol-Myers Squibb akabatana maoko naPfizer kuzivisa kubatana mukugadzirwa kweoral anticoagulant apixaban yeBristol-Myers Squibb seimwe nzira yakakwidziridzwa yewarfarin.Maererano nechibvumirano chekushandira pamwe, Pfizer ichabhadhara mari yekumberi yeUS $ 0.25 bhiriyoni kuBristol-Myers Squibb kuti itakure makumi matanhatu muzana emutengo wakakwana wekuvandudza anticoagulant apixaban (ichaitwa kubva muna Ndira 1, 2007), ukuwo Bristol-Myers. Squibb ichabereka makumi mana muzana asara, nokudaro kuwana kodzero yekugadzira pamwe chete nekutengesa mushonga.Muna Chivabvu 2011, apixaban ndiyo yaive yekutanga kubvumidza kudzivirira kwevenous thrombosis muvarwere vakura vanovhiyiwa kusarudzwa hudyu kana kutsiva mabvi munyika dze27 EU, Iceland neNorway.Musi waNovember 20, 2012, European Commission yakabvumira Ererto (apixaban) yekudzivirira sitiroko uye systemic embolism muvarwere vakura vane non-valvular atrial fibrillation (NVAF) ine imwe kana zvimwe zvinokonzera ngozi.Zvadaro, iyo Canadian Chikafu neDrug Administration, Japan, uye US FDA yakabvumidza Ererto?(apixaban) yekudzivirira kwekurohwa uye systemic embolism muvarwere vakura vane non-valvular atrial fibrillation (NVAF) ine imwe kana zvimwe zvinokonzera ngozi.Musi waKubvumbi 12, 2013, iyo itsva anticoagulant drug Eloto (ELIQUIS) (apixaban) yakabatanidzwa neBristol-Myers Squibb uye Pfizer yakaziviswa zviri pamutemo kuti yakanyorwa muChina.Ererto inoveli oral factor Xa inhibitor yekudzivirira venous thromboembolism (VTE) muvarwere vakuru vari kusarudzwa hudyu kana kutsiva ibvi.Rondedzero yaro inopa yakachengeteka uye inoshanda sarudzo nyowani yekiriniki anticoagulation mushure mekuvhiyiwa kwemapfupa, uye inounza nhau dzakanaka kuvarwere veChinese vari kutsiva hudyu/mabvi.Zvidzidzo zvekiriniki zvakasimbisa kuti zvichienzaniswa ne40mg enoxaparin kamwe chete pazuva, 2 kanomwe pazuva nemuromo wekutonga eratol?(apixaban) 2.5mg inonyanya kushanda pakudzivirira venous thromboembolism mushure mekuvhiyiwa kwehudyu kana mabvi, uye haiwedzere ngozi yekubuda ropa.Mufananidzo 1 unoratidza mahwendefa eElotoapixaban anogadzirwa naBristol-Myers Squibb uye Pfizer.
![Apixaban Yepakati CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)](https://www.ruifuchemical.com/uploads/Apixaban-Intermediate-CAS-490-46-0-Factory-Shanghai-Ruifu-Chemical-Co.-Ltd.-www.ruifuchem.com_-300x300.jpg)
