Purogiramu inonzi Aripiprazole CAS 129722-12-9 Purity >99.0% (HPLC)
Mugadziri Wekugovera Vepakati veAripiprazole NeKuchena Kwakanyanya
Aripiprazole API CAS 129722-12-9
1-(2,3-Dichlorophenyl)piperazine Hydrochloride CAS 119532-26-2
7-Hydroxy-3,4-Dihydro-2(1H)-Quinolinone CAS 22246-18-0
7-(4-Bromobutoxy)-3,4-Dihydro-2(1H)-Quinolinone CAS 129722-34-5
| Chemical Name | Aripiprazole |
| Mashoko anoreva zvakafanana | 7-[4-[4-(2,3-Dichlorophenyl)-1-Piperazinyl]butoxy]-3,4-Dihydro-2(1H)-Quinolinone |
| Nhamba yeCAS | 129722-12-9 |
| Nhamba yeCAT | RF-PI2270 |
| Stock Status | MuStock, Kugadzirwa Kunokwira Kusvika Matani |
| Molecular Formula | C23H27Cl2N3O2 |
| Molecular Weight | 448.39 |
| Solubility | Insoluble Soluble mumvura;Insoluble muMethanol |
| Brand | Ruifu Chemical |
| Item | Zvinotsanangurwa |
| Chitarisiko | Ichena kana Inenge Yakachena Crystalline Powder |
| Identification | By IR;By HPLC |
| Solubility | Soluble muAcetic Acid, Zvishoma Soluble muEthanol |
| Melting Point | 136.0~140.0℃ |
| Kurasika paKuomesa | <0.50% |
| Residue paIgnition | <0.10% |
| Heavy Metals | ≤20ppm |
| Residual Solvents | |
| Ethanol | ≤1000ppm |
| DMF | ≤200ppm |
| Related Substances | |
| Chero Kusachena Kumwe | <0.20% |
| Zvose Zvisina Kuchena | <1.00% |
| Kuchena / Analysis Method | >99.0% (HPLC) |
| Assay | 98.0% ~ 102.0% (paAnhydrous Basis) |
| Micro Limits | |
| Total Aerobic Microbial Count | ≤1000 cfu/g |
| Mbiriso uye Mold zvakasanganiswa | ≤100 cfu/g |
| E·Coli | Kusavapo |
| Pathogenic Kuronga | Kusavapo |
| Test Standard | Enterprise Standard |
| Usage | API;Antipsychotic |
Package: Bhodhoro, 5kg/Aluminium tin, 25kg/Cardboard Drum, kana maererano nezvinodiwa nemutengi
Storage Condition:Chengetedza mumidziyo yakavharwa panzvimbo inotonhorera uye yakaoma;Dzivirira kubva kuchiedza uye unyoro
Aripiprazole (CAS: 129722-12-9) rudzi rutsva rwezvakanyanya lipid soluble quinoline derivatives, iyo pharmacological mhedzisiro hunhu ndeyekuti haisi chete postsynaptic dopamine D2 receptor antagonist, asiwo presynaptic dopamine D2 receptor agonist, inogona zvakare. fadza D1, D3, D4 receptors.Aripiprazole chizvarwa chechipiri atypical antipsychotic uye anti-depressant ine chikamu agonist chiitiko pa dopamine D2 uye serotonin 5-HT1A receptors uye anopikisa chiitiko pa serotonin 5-HT2A receptors.Ki values ndeye 0.34 nM, 0.8 nM, 1.7 nM, uye 3.4 nM, zvichiteerana, ye dopamine D2 uye D3, serotonin 5-HT1A uye 5-HT2A receptors.Aripiprazole inoshandiswa kurapa schizophrenia uye zvine hukama psychotic kusagadzikana.Bristol-Myers Squibb uye Otsuka Pharmaceutical Company yakazivisa kuti European Union yakabvumidza Abilify (Aripiprazole) mukurapa schizophrenia rondedzero application.Schizophrenia inobata 1% yehuwandu hwepasi rose, uye zvakanyanya muvakuru vechidiki.Schizophrenia inokanganisa kufunga, kudzora manzwiro uye kugona kuita sarudzo kwemurwere.Varwere vane schizophrenia-positive vachave nezviratidzo zvakadai sekufungidzira uye kunyengedza, varwere vane zviratidzo zvakashata ndezvekurega kushamwaridzana, kushaya kuchinja kwepfungwa.Muna 2002 FDA yakabvumira Abilify kurapwa kweschizophrenia, iyo ine masimba mashanu emushonga: 5 mg, 10 mg, 15 mg, 20 mg uye 30 mg, kubva payakabvumidzwa.
