Bacitracin Zinc CAS 1405-89-6 Potency ≥70 IU/mg Peptide Antibiotic Factory
Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri uye mutengesi weBacitracin Zinc (Zinc Bacitracin) (CAS: 1405-89-6) ine mhando yepamusoro.Isu tinogona kupa COA, kuendesa pasi rese, zvidiki uye huwandu hwakawanda huripo.Kana iwe uchifarira Bacitracin Zinc (Zinc Bacitracin),Please contact: alvin@ruifuchem.com
| Chemical Name | Bacitracin Zinc |
| Mashoko anoreva zvakafanana | Bacitracin Zinc Munyu;Zinc Bacitracin |
| Stock Status | MuStock, Kukwanisa Kugadzira Matani gumi pagore |
| Nhamba yeCAS | 1405-89-6 |
| Molecular Formula | C66H101N17O16SZn |
| Molecular Weight | 1486.07 |
| Melting Point | 250 ℃ (Zvita.) |
| Mvura Solubility | 5.1 g/L |
| COA & MSDS | Available |
| Muenzaniso | Available |
| Brand | Ruifu Chemical |
| Items | Zvinotsanangurwa | Results |
| Chitarisiko | Ichena kana Chiedza Yero-Grey kana Beige Powder | Conforms |
| Identification | Ita Zvinodiwa | Appear Positive Reaction |
| pH | 6.0~7.5 | 7.1 |
| Kurasika paKuomesa | ≤5.0% | 2.7% |
| Zinc (Dried Substance) | 4.0%~6.0% | 4.20% |
| Potency | ≥70 IU/mg Microbial Assay (Yakaoma) | 71 IU/mg |
| Zviri mukati meBacitracin A | ≥40.0% | 58.2% |
| Zvemukati zveActive Bacitracin | ≥70.0% (Bacitracin A, B1, B2, uye B3) | 86.1% |
| Muganhu Wekutanga Eluting Peptides | ≤20.0% | 7.6% |
| Muganhu weBacitracin F | ≤6.0% | 1.1% |
| Total Viable Aerobic Count | <100 CFU/gram | Conforms |
| Mhedziso | Chigadzirwa Chinoenderana neUSP44 Mitemo | |
| Main Kushandiswa | Peptide Antibiotic | |
Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.
Bacitracins, zinc yakaoma.
Bacitracins zinc yakaoma [1405-89-6].
» Bacitracin Zinc ndiyo zinc complex ye bacitracin, iyo ine musanganiswa we antimicrobial polypeptides, iyo huru inoumba bacitracins A, B1, B2, uye B3.Iine potency isingasviki 65 Bacitracin Units per mg, inoverengwa pane yakaomeswa.Inosanganisira kwete pasi pe4.0 muzana uye kwete kupfuura 6.0 muzana ye zinc (Zn), yakaverengerwa pane yakaomeswa.
Kurongedza uye kuchengetedza- Chengetedza mumidziyo yakaoma, uye chengeta munzvimbo inotonhorera.
Kunyora-Kuisa iyo kuratidza kuti inofanirwa kushandiswa mukugadzirwa kwemishonga isiri yevabereki chete.Iro payakarongedzerwa kusanganiswa kwemishonga, inyore kuti iratidze kuti haina utachiona uye kuti potency haigone kuvimbiswa kwenguva yakareba kupfuura mazuva makumi matanhatu mushure mekuvhurwa, uye kutaura nhamba yeBacitracin Units pamilligram.Painoitirwa kuti ishandiswe mukugadzira mafomu emushonga asina kuchena, iyo label inotaura kuti haina mbereko kana kuti inofanirwa kuenderera mberi nekugadziriswa panguva yekugadzirira mafomu ekuora.
USP Reference mwero <11>-
USP Bacitracin Zinc RS
Identification-
A: Thin-Layer Chromatographic Identification Test <201BNP>: inosangana nezvinodiwa.
B: Inosangana nezvinodiwa zveiyo liquid chromatographic maitiro muyedzo yeComposition.
Sterility <71>-Iko iyo label inotaura kuti haina mbereko, inosangana nezvinodiwa kana ichiongororwa sekunangwa kweMembrane Filtration pasi peMuedzo weSterlity yeChigadzirwa kuti iOngororwe, kunze kwekushandisa Fluid A kune imwe neimwe L iyo yakawedzerwa makumi maviri. g ye edetate disodium.
pH <791>: pakati pe6.0 ne7.5, mune (yakazara) mhinduro ine inenge 100 mg pa mL.
Kurasikirwa pakuomeswa <731> -Dry about 100 mg mu capillary-stoppered bottle in vacuum pa 60 kwemaawa matatu: inorasikirwa kwete kupfuura 5.0% yehuremu hwayo.
Zinc yemukati- [Cherechedzo-Iyo Magadzirirwo Echinyakare uye Kugadzirira kweMuedzo kunogona kuderedzwa zvakanyanya ne 0.001 N hydrochloric acid, kana zvichidikanwa, kuwana mhinduro dzekuisa kwakakodzera, kuchinjika kune mutsara kana kushanda kwechiridzwa.]
Kugadzirira kwakajairwa-Kutamisa 3.11 g ye zinc oxide, yakanyatso kuyerwa, kune 250-mL volumetric flask, wedzera 80 mL ye 1 N hydrochloric acid, inodziya kunyungudika, inotonhorera, diluted nemvura kusvika kuhuwandu, uye sanganisa.Mhinduro iyi ine 10 mg ye zinc pa mL.wedzera diluisa mhinduro iyi ne 0.001 N hydrochloric acid kuti uwane Magadzirirwo akaenzana ane 0.5, 1.5, uye 2.5 µg ye zinc pa mL, zvichiteerana.
Kugadzirira kwekuedza-Kutamisa nezve 200 mg yeBacitracin Zinc, yakanyatsoyerwa, kune 100-mL volumetric flask.Dissolve mu 0.01 N hydrochloric acid, dilue neyakafanana solvent kusvika kuhuwandu, uye sanganisa.Pipet 2 mL yemhinduro iyi mu200-mL volumetric flask, dilute ne 0.001 N hydrochloric acid kusvika kuhuwandu, uye sanganisa.
Maitiro-Saizvozvo tarisa kunyura kweiyo Standard gadziriro uye Kugadzirira kweMuedzo pane zinc resonance mutsara we213.8 nm, ine yakakodzera atomic absorption spectrophotometer (ona Spectrophotometry uye Chiedza-kuparadzira <851>), ine zinc hollow-cathode rambi uye murazvo wemhepo-acetylene, uchishandisa 0.001 N hydrochloric acid seyakashama.Ronga kunyura kweiyo Standard gadziriro maringe nekutarisa, muµg per mL, yezingi, uye dhirowa mutsara wakatwasuka unonyatsokodzera mapoinzi matatu akarongwa.Kubva pane girafu rawanikwa, sarudza iyo yekumisikidza, muµg pa mL, ye zinc muMuedzo kugadzirira.Verenga zvirimo zve zinc, mu muzana, muchikamu cheBacitracin Zinc chakatorwa neformula:
1000C / W
umo C ndiyo chiyero mu µg per mL, ye zinc mukugadzirira Test;uye W ndiyo huremu, mumg, yechikamu cheBacitracin Zinc chakatorwa.
Kuumbwa-
Buffer- Dissolve 34.8 g ye potassium phosphate, dibasic, mu 1 L yemvura.Rongedza ne 27.2 g ye potassium phosphate, monobasic, yakanyungudutswa mu 1 L yemvura, kusvika pH ye6.0.
Nharembozha-Gadzirira musanganiswa wemethanol, mvura, Buffer, uye acetonitrile (26:15:5:2).Sakanidza zvakanaka, uye degas.
Diluent-Dissolve 40 g ye edetate disodium mu 1 L yemvura.Rongedza ne dilute sodium hydroxide kune pH ye7.0.
Kukodzera kweSystem solution-Dyisa huwandu hwakayerwa nemazvo hweUSP Bacitracin Zinc RS muDiluent kuti uwane mhinduro ine zita rekuti 2.0 mg per mL.
Kushuma pachikumbaridzo mhinduro-Dhirudza quantitatively, nemvura, vhoriyamu yakakodzera yeSystem suitability solution kuti uwane mhinduro ine inozivikanwa ye 0.01 mg per mL.
Peak identification solution-Dyisa huwandu hwakayerwa hweUSP Bacitracin Zinc RS muhuwandu hwakakodzera hweDiluent kuti uwane mhinduro ine zita rekuti 2.0 mg per mL.Pisa mumvura inofashaira yekugeza kwemaminetsi makumi matatu.Kutonhorera kusvika kukamuri tembiricha.
Muedzo wemhinduro-Dyisa huwandu hwakayerwa nemazvo eBacitracin Zinc muDiluent kuti uwane mhinduro ine zita rekuti 2.0 mg per mL.
Chromatographic system (ona Chromatography <621>) -Iyo chromatograph yemvura yakashongedzerwa neabsorbence detector uye yekupedzisira-capped 4.6- × 250-mm column ine 5-µm packing L1.Chiyero chekuyerera ndeye 1.0 mL paminiti.Isa iyo wavelength ye detector pa 300 nm.Jekiseni nezve 100 µL yePeak identification solution, uye tsvaga nzvimbo yebacitracin F, inova kusachena kunozivikanwa, uchishandisa nguva yekuchengetedza inoratidzwa muTafura 1.
Tafura 1
Zita rechikamu Relative Retention Time (inenge)
Bacitracin C1 0.5
Bacitracin C2 0.6
Bacitracin C3 0.6
Bacitracin B1 0.7
Bacitracin B2 0.7
Bacitracin B3 0.8
Bacitracin A 1.0
Bacitracin F 2.4
Chinja wavelength ye detector uye uise ku 254 nm.Chromatograph the System suitability solution, uye rekodha mhinduro dzepamusoro sekutaurirwa kweChirongwa: tsvaga nhongonya dzezvakanyanya kushanda zvikamu zvebacitracin (bacitracins A, B1, B2 uye B3), peptides yekutanga eluting (iyo inobuda pamberi pepamusoro nekuda kwebacitracin B1. ) uye kusachena, bacitracin F, uchishandisa hukama hwekuchengetedza nguva ukoshi hwakapihwa muTebhurari 1. Verenga reshiyo yepeak-to-valley uchishandisa formula:
Hp / HV
umo Hp iri kureba pamusoro pekutanga kwepamusoro nekuda kwebacitracin B1;uye HV ihwo hurefu huri pamusoro penheyo yepamusoro yenzvimbo yakaderera ye curve inoparadzanisa bacitracin B1 peak kubva panhongonya nekuda kwebacitracin B2.Iyo peak-to-valley ratio haisi pasi pe1.2.
Maitiro-Kuparura jekiseni akaenzana mavhoriyamu (100 µL) eDiluent, Muedzo mhinduro, uye Reporting pachikumbaridzo mhinduro.Rekodha machromatograms kwekanenge katatu nguva yekuchengetedza yebacitracin A. Ziva nhongonya uchishandisa nguva dzekuchengetedza dzinoratidzwa muTable 1. Edza nzvimbo dzepamusoro dzepamusoro pese mumhinduro yeKuedza.[noti-Rega chero peak muTest solution ine nzvimbo yakaderera pane nzvimbo yebacitracin A peak muReporting threshold solution;kusava nehanya nenhongonya ipi neipi inoonekwa muDiluent.]
cherechedzo-Nzvimbo yose mukuverenga kunotevera inotsanangurwa senzvimbo yezvikwiriso zvese kunze kwechikumbaridzo chekuzivisa.
Zvirimo mu bacitracin a- Verenga huwandu hwe bacitracin A uchishandisa fomula:
(rA / Yese nzvimbo) × 100
umo rA ndiyo nzvimbo inopindurwa nebacitracin A. Bacitracin A zvinyorwa hazvisi pasi pe40.0% yeTotal area.
zviri mukati meiyo inoshanda bacitracin- Verenga iyo muzana yeanoshanda bacitracin (bacitracin A, B1, B2, uye B3) uchishandisa formula:
(rA + rB1 + rB2 + rB3 / Total nzvimbo)×100
umo rA, rB1, rB2, uye rB3 ndiwo mhinduro dzenharaunda kubva kune bacitracin A, B1, B2, uye B3, zvichiteerana.Huwandu hwebacitracin A, B1, B2, uye B3 haisi pasi pe70.0% yeTotal area.
muganhu wemapeptides ekutanga-Eresa chikamu chepamusoro pese peaks inodonhedza pamberi pepamusoro nekuda kwebacitracin B1 uchishandisa formula:
(rPreB1 / Yese nzvimbo) ×100
umo rPreB1 ndiyo nhamba yemhinduro dzenhongonya dzese dziri kubuda pamberi penhongonya yebacitracin B1.Muganho wekutanga eluting peptides (iwo anozeza pamberi pepamusoro nekuda kwebacitracin B1) haasi kupfuura 20.0%.
muganho webacitracin f- Verenga iyo muzana ye bacitracin F uchishandisa iyo formula:
100 × (rF / rA)
umo rF ndiyo mhinduro ye bacitracin F kubva kuMuedzo mhinduro;uye rA ndiyo mhinduro ye bacitracin A kubva kuMuedzo mhinduro.Muganho webacitracin F, kusvibiswa kunozivikanwa, hakusi kudarika 6.0%.
Assay-Pfuura neBacitracin Zinc sekurairwa pasi peAntibiotics-Microbial Assays 81.
Kutenga sei?Please contactDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Makore 15 Oupenyu?Tine makore anopfuura 15 ane ruzivo mukugadzira uye kutumira kunze kwemhando dzakasiyana-siyana dzepamusoro dzemishonga yepakati kana makemikari akanaka.
Main Markets?Tengesa kumusika wepamba, North America, Europe, India, Korea, Japan, Australia, nezvimwe.
Zvakanakira?Hunhu hwepamusoro, mutengo unokwanisika, masevhisi ehunyanzvi uye rutsigiro rwehunyanzvi, kuendesa nekukurumidza.
HunhuSimbiso?Strict quality control system.Midziyo yehunyanzvi yekuongorora inosanganisira NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, nezvimwe.
Samples?Zvigadzirwa zvakawanda zvinopa mahara emahara ekuongorora kwemhando, mutengo wekutumira unofanirwa kubhadharwa nevatengi.
Factory Audit?Factory audit inogamuchirwa.Ndapota itai nguva isati yasvika.
MOQ?Hapana MOQ.Kurongeka kudiki kunogamuchirwa.
Delivery Nguva? Kana mukati me stock, mazuva matatu kutumirwa anovimbiswa.
Transportation?Ne Express (FedEx, DHL), neMhepo, neGungwa.
Zvinyorwa?Mushure mekutengesa sevhisi: COA, MOA, ROS, MSDS, nezvimwe zvinogona kupihwa.
Custom Synthesis?Inogona kupa echinyakare synthesis masevhisi kuti aenderane nezvinodiwa zvako zvekutsvagisa.
Payment Terms?Proforma invoice inozotumirwa kutanga mushure mekusimbisa kurongeka, yakavharirwa ruzivo rwedu rwebhangi.Kubhadhara neT/T (Telex Transfer), PayPal, Western Union, nezvimwe.
Tsanangudzo Yekuchengetedza S22 - Usafeme guruva.
S24/25 - Dzivisa kusangana neganda nemeso.
WGK Germany 3
FLUKA BRAND F CODES 3
HS Code 2941909099
Bacitracin inotorwa kubva mumushonga wetsika ye lichen (Bacillus licheniformis) uye mushonga wepolypeptide.Upfu huchena kana hushoma hweyero, husina hwema kana hunonhuwa zvishoma, kuravira kunovava, hygroscopic.Zviri nyore kunyungudika mumvura uye ethanol, isina kugadzikana, aqueous solution inogadziriswa nyore nyore pakupisa kwekamuri, isina kugadzikana papH 9, uye inofanira kuiswa mufiriji mufiriji mushure mekuparadzwa.Ichi chigadzirwa chinoverengwa sechigadzirwa chakaoma, uye titer pa milligram haifaniri kunge iri pasi pe55 bacitracin units.Bacitracin zinc is bacitracin zinc munyu, iyo yakagadzikana kupfuura bacitracin.Inoshandiswa sekuwedzera kwekudya uye ine mabasa ekusimudzira kukura uye kukura kwezvipfuyo nehuku, kudzivirira hutachiona hwematumbo, uye kuwedzera mubhadharo wekudya.Muyero wacho wakafanana nebacitracin.Bacitracin antibacterial spectrum yakafanana nepenicillin, iyo ine yakasimba antibacterial mhedzisiro pagiramu-positive mabhakitiriya uye haina mhedzisiro inooneka pagiremu-negative mabhakitiriya.Nokuda kwezvirwere zvakakomba zvemishonga inopesana nemishonga Staphylococcus aureus.Oral administration haina kubatwa uye inoshandiswa pahutachiona hwematumbo.Kushandiswa kwekunze kunoshandawo kumuviri wepamusoro, wemukanwa uye nehutachiona hwemaziso uye mastitis inokonzerwa nehutachiona hwehutachiona.Iine zvinokuvadza paitsvo.Bacitracin zinc yakashandiswa sechikafu chekuwedzera mushonga.Kudzora nemuromo hakumbobatiki, saka zvinotendwa kuti hapana dambudziko rekusarira kwemishonga muzvipfuyo nemuzvigadzirwa zvehuku.Ichi chigadzirwa chinonzi nhete-spectrum antibiotic, ine simba rinorwisa mabhakitiriya kune akawanda mabhakitiriya e gram-positive.Inoshandawo pakurwisa spirochetes uye actinomycetes, asi haishande pakurwisa giremu-negative mabhakitiriya.Iine synergistic effect ine zvakasiyana-siyana zvemishonga inorwisa mabhakitiriya yakadai se penicillin G, streptomycin, neomycin, polymyxin, etc. Zinc munyu waro unonyanya kushandiswa sekuwedzera kwekudya, iyo ine mabasa ekudzivirira hutachiona hwematumbo, kukurudzira kukura nekuvandudza mubhadharo wekudya.Utachiona hunogona kukura zvishoma nezvishoma kuramba kuchigadzirwa ichi, asi hapana kupesana pakati pechigadzirwa ichi nemamwe mishonga inorwisa mabhakitiriya.Ichi chigadzirwa chine muchetura zvakanyanya uye hachigone kubaiwa.Inogona kutorwa nemuromo kurapa manyoka ebhakitiriya muzvipfuwo uye Treponema dysentery munguruve.Muchipatara, inowanzoshandiswa pamwe chete nemishonga yakasiyana-siyana yakadai sepenicillin, streptomycin, neomycin, polymyxin B, nezvimwewo kuwedzera kushanda.
Bacitracin Zinc yakaoma inoumbwa nebacitracin uye zinc ions.Mushonga unorwisa mabhakitiriya wepolypeptide uye ndiwo unonyanyo shandiswa mushonga wekupa chikafu pari zvino.iyo zinc yemukati inowanzo 2% ~ 12%.Zvigadzirwa zveSynthetic zvichena kana yero, zvine kunhuwa kwakakosha, zviri nyore kunyungudika kuita zvinhu zvine alkaline zvisina simba, uye zvinonyungudika zviri nyore mumvura, methanol uye ethanol.Bacitracin zinc ine yakasimba antibacterial mhedzisiro inopesana neGram-positive bacteria, uye zvakare ine antibacterial properties kurwisa mamwe mabhakitiriya eGram-negative.Kushandiswa kwebacitracin zinc munguruve yakazara-mutengo wekudya kunogona kukurudzira kukura, kunatsiridza mubhadharo wekudya, uye kudzivirira nguruve bhakitiriya manyoka uye zvirwere zvisingaperi zvekufema.Kuwedzera kwekuwedzera kunowanzo 10 ~ 100mg / kg, uye mhedzisiro yacho haina kunyatso kuvandudzwa kupfuura iyo yekuwedzera huwandu.Bacitracin Zinc haiwanzo kunyura mumatumbo enguruve, saka hapana dambudziko rekusarira.Iyo yakachengeteka uye yakavimbika antibiotic additive.Bacitracin Zinc ine muchetura zvakanyanya uye haisi nyore kutorwa nemudumbu, saka haigone kushandiswa semushonga wezvirwere zve systemic.
Polypeptide mishonga inorwisa mabhakitiriya ine yakasimba antibacterial mhedzisiro pagiramu-positive mabhakitiriya, uye zvakare ine antibacterial mhedzisiro pane mashoma giremu-negative mabhakitiriya, spirochetes, actinomycetes uye kunyange penicillin-resistant staphylococci.Iyo antibacterial maitiro ndeyekutadzisa kuumbwa kwebhakitiriya sero madziro uye kukuvadza bhakitiriya sero plasma membrane.Inogona kukurudzira kukura kwezvipembenene zvinobatsira mumatumbo, kuwedzera kupindira kwemukati mucosa, uye kukurudzira kunwa kwezvokudya.Inonyanya kushandiswa kukurudzira kukura kwezvipfuyo nehuku, kudzivirira uye kudzora manyoka ebhakitiriya ezvipfuwo uye huku uye ropa remanyoka anokonzerwa neTreponema.Bacitracin zinc haigoni kunyura mukati, uye yakawanda yacho inobudiswa netsvina mukati memazuva maviri, saka hazvisi nyore kuramba uri muzvipfuwo uye huku;mabhakitiriya haawanzoita kurwisa bacitracin, uye haapikisane nemamwe maantibioti, Uye ane synergistic effect ne penicillin, streptomycin, neomycin, aureomycin, polymyxin, nezvimwewo. Ichi chigadzirwa chine chepfu zvakanyanya uye hachigoni kubayiwa.Ichi chigadzirwa chinopikiswa neolaquindox, kitasamycin, virginiamycin, uye Enramycin.
Sekuwedzera kwekudya, inonyanya kushandiswa kusimudzira kukura kwezvipfuwo nehuku, kudzivirira manyoka ebhakitiriya ezvipfuwo uye huku uye ropa reropa rinokonzerwa ne treponema.Bacitracin zinc haigoni kunyura mukati, uye yakawanda yacho inobudiswa netsvina mukati memazuva maviri, saka hazvisi nyore kuramba uri muzvipfuwo uye huku;mabhakitiriya haawanzoita kurwisa bacitracin, uye haapikisane nemamwe maantibioti, Uye ane synergistic effect ne penicillin, streptomycin, neomycin, aureomycin, polymyxin, nezvimwewo. Ichi chigadzirwa chine chepfu zvakanyanya uye hachigoni kubayiwa.Ichi chigadzirwa chinopikiswa neolaquindox, kitasamycin, virginiamycin, uye Enramycin.
Bacitracin Zinc inonzi polypeptide antibiotic, ine bactericidal effect pa gram-positive bacteria.Maitiro ayo anonyanya kuvharidzira bhakitiriya madziro synthesis yebhakitiriya, uye inogonawo kusanganisa nesero membrane yeanonzwa mabhakitiriya, kukuvadza kutendeseka kwesero membrane, uye kukonzera Kubuda kwezvinhu zvakakosha muchitokisi.Zvinobudirira inhibit Gram-positive mabhakitiriya uye mamwe mabhakitiriya eGram-negative;chiyero chekudzivirira kwebhakitiriya kune bacitracin zinc inononoka, uye hapana kupesana nemamwe maantibioti.polypeptide mishonga inorwisa mabhakitiriya inhibit dephosphorylation ye lipid pyrophosphate, nokudaro inhibiting synthesis yebhakitiriya sero madziro.
