Baloxavir Marboxil CAS 1985606-14-1 API Factory High Quality

Tsanangudzo Pfupi

Kemikari Zita: Baloxavir Marboxil

CAS: 1985606-14-1

Chitarisiko: Muchena kusvika Kuchena-Upfu

Chiyero: 98.0% ~ 102.0%

Mukurapa Influenza A uye Influenza B Infections

Bata: Dr. Alvin Huang

Nharembozha/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Tumira email kwatiri

Product Detail

Product Tags

Tsanangudzo:

Shanghai Ruifu Chemical Co., Ltd. ndiyo inotungamira mugadziri weBaloxavir Marboxil (CAS: 1985606-14-1) ine mhando yepamusoro.Ruifu Chemical inogona kupa kutumirwa kwepasirese, mutengo wemakwikwi, sevhisi yakanakisa, idiki uye yakawanda huwandu huripo.Tenga Baloxavir Marboxil,Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	Baloxavir Marboxil
Mashoko anoreva zvakafanana	BXM;S-033188
Nhamba yeCAS	1985606-14-1
Stock Status	MuStock, Kugadzirwa Kunokwira Kusvika Mazana emaKilogram
Molecular Formula	C27H23F2N3O7S
Molecular Weight	571.55
Density	1.57±0.10 g/cm3
Solubility	Soluble muDMSO
Kuchengetedza Kwenguva Yakareba	Chengetedza Nguva refu pa -20 ℃
COA & MSDS	Available
Origin	Shanghai, China
Brand	Ruifu Chemical

Zvinotsanangurwa:

Item	Zvinotsanangurwa
Chitarisiko	Ichena kusvika kuOff-White Powder
Identification	Iyo IR Spectrum inoenderana nereferenzi standard Nguva yekuchengetedza inoenderana nereferensi standard
Mvura Yemukati (neKF)	≤1.0%
Kurasika paKuomesa	≤1.0%
Residue paIgnition	≤0.50%
Heavy Metals	≤20ppm
Related Substances
Maximum Individual Kusachena	≤0.50%
Zvose Zvisina Kuchena	≤1.0%
Particle Size	D90 Pass 150um
Chiral Purity	≥99.0%
Kuchena	≥99.0%
Assay	98.0%~102.0%
Residual Solvents	Teerera neICH Zvinodiwa
Shipping	Kutumira Ne Ice Pack
Test Standard	Enterprise Standard
Usage	API, mukurapa Influenza A uye Influenza B Infections

Package & Kuchengeta:

Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~8℃) uye inofefeterwa nemhepo yakanaka kure nezvinhu zvisingaenderane.Dzivirira kubva kuchiedza uye unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.

Zvakanakira:

FAQ:

1985606-14-1 - Application:

Baloxavir Marboxil (CAS: 1985606-14-1, BXM, S-033188, Xofluza) mushonga unorwisa hutachiona wakagadzirwa neShionogi Co., kambani yeJapan yemishonga uye Roche yekurapa furuwenza A uye furuwenza B.Mushonga uyu wakatanga kubvumidzwa kuti ushandiswe muJapan muna Kukadzi 2018 uye wakabvumidzwa neFDA muna Gumiguru 24, 2018 kurapwa kwefuruwenza muvarwere vane makore gumi nemaviri zvichikwira vanga vaine zviratidzo kweanopfuura maawa makumi mana nemasere Label.Baloxavir marboxil, cap-endonuclease inhibitor, ine maitiro akasiyana ekuita kana ichienzaniswa neiyo iripo neuraminidase inhibitor drug class inoshandiswa kurapa utachiona hwefuruwenza.Baloxavir Marboxil mushonga mutsva unorwisa furuwenza ine maitiro matsva ekuita.Baloxavir Marboxil chigadzirwa cheBaloxavir Acid (S-033447) chinovharisa zvine simba uye nekusarudza iyo cap-dependent endonuclease mukati mepolymerase PA subunit yefuruenza A uye B mavhairasi, zvichitungamira mukudzivirirwa kweRNA kunyora uye kudzokorora.Baloxavir yakawongororwawo kuti inogona kurapa COVID-19 asi hapana bhenefiti yakaonekwa yaonekwa.

1985606-14-1 - Nzira Yekuita:

Baloxavir Marboxil influenza therapeutic agent, kunyanya, enzyme inhibitor yakanangana nefuruwenza virus 'cap-dependent endonuclease chiitiko, chimwe chezviitiko zvehutachiona hwepolymerase complex.Kunyanya, inovharidzira maitiro anozivikanwa secap snatching, iyo hutachiona hunotora mapfupi, akavharirwa maprimers kubva kune host cell RNA zvinyorwa, izvo zvinoshandisa kune polymerase-catalyzed synthesis yeinodiwa hutachiona mRNAs.A polymerase subunit inosunga kune anotambira pre-mRNAs pa5' caps, ipapo polymerase's endonuclease chiitiko chinokonzeresa kutsemuka kwayo "mushure megumi-13 nucleotides".Saka nekudaro, maitiro ayo akasiyana neuraminidase inhibitors akadai seOseltamivir neZanamivir.

1985606-14-1 - Pharmacokinetics:

Baloxavir Marboxil is selective inhibitor of influenza cap-dependent endonuclease iyo inodzivirira polymerase function uye naizvozvo furuwenza virus mRNA replication 5, 3. Yakaratidza basa rekurapa kurwisana nefuruwenza A uye B utachiona hwehutachiona, kusanganisira madhiri anopikisa ikozvino antiviral agents 1. Mushonga uyu inhibits enzyme inodiwa pakudzokororwa kwevhairasi, nekudaro kukurumidza kurapa furuwenza utachiona hwehutachiona 5, Nyora uye kuderedza zviratidzo zvine chekuita nehutachiona.Chiyero chimwe chete chemumiririri uyu chakaratidzwa kuva chepamusoro kune placebo mukubvisa zviratidzo zvefuruwenza uye yakakwirira kune oseltamivir uye placebo mushonga mumigumisiro ye virologic (yakaratidzwa nekuderera kwehutachiwana).

1985606-14-1 - Zviratidzo:

Baroxavir inokodzera varwere vane makore ≥ gumi nemaviri ekuberekwa vanorwara nefuruwenza uye vane zviratidzo zvisingapfuure maawa makumi mana nemasere.Kuchenjerera kunofanira kubhadharwa kune zvisingakwanisi zvemishonga: hutachiona hwefuruwenza hunochinja nekufamba kwenguva, uye pane zvinhu zvakadai sehutachiwana hwehutachiwana uye subtype.Kamwe kurwisa kwemishonga kwehutachiona uye pathogenicity yehutachiona huchichinja, kushanda kwekiriniki kwemishonga inorwisa mavhairasi kunogona kuderedzwa.Pakusarudza kana kutora basalovir dipivoxil, ruzivo rwuripo pamusoro pekunzwa kwehutachiwana hwehutachiona hwemunharaunda kumushonga hunofanirwa kutariswa.

1985606-14-1 - Zvishandiso:

Baloxavir Marboxil mushonga wefuruwenza, antiviral, unotorwa se piritsi rimwe chete, nemuromo, nevanhu vane makore gumi nemaviri kana kupfuura, vakaratidza zviratidzo zvechirwere ichi kwemaawa asingadarike 48. Kushanda kwe baloxavir marboxil inopihwa mushure memaawa makumi mana nemasere isati yaongororwa.

1985606-14-1 - Contraindications:

Baloxavir Marboxil haifanirwe kupihwa pamwe chete nezvigadzirwa zvemukaka, zvinwiwa zvine calcium-fortified, kana laxatives, antacids, kana zvemumuromo zvinowedzera zvine calcium, iron, magnesium, selenium, aluminium kana zinc.

1985606-14-1 - Zvikonzero:

Zvakajairwa mhedzisiro zvichitevera kupihwa imwe dosi ye baloxavir marboxil inosanganisira manyoka, bronchitis, kutonhora, musoro, uye kusvotwa.Zviitiko zvakashata zvakataurwa mu21% yevanhu vakagamuchira baloxavir, 25% yeavo vanogamuchira placebo, uye 25% yeOseltamivir.

1985606-14-1 - Kugadzirira:

Japanese patent JP6212678 yakashuma iyo synthesis nzira yeBaloxavir Marboxil.3, 4-difluorobenzoic asidhi yakashandiswa seyakagadziriswa kuita neDMF pasi pechiito cheLDA kuwana 2-formyl-3, 4-difluorobenzoic acid.Zvadaro inoumba thioacetal ne thiophenol, zvino inoderedzwa uye yakaparadzaniswa neborane kuwana 2-phenylthiomethyl -3, 4-difluorob, 8-difluorodibenzo [B, e] thiazepine -11 (6H) -imwe, uye pakupedzisira key thiazepine fragment. 7, 8-difluoro-6,11-dihydrodibenzo [B, e] thiazepine -11-doro inowanikwa pasi pekuderedza sodium borohydride.Kushandisa 3-(benzyloxy) -4-oxo-4H-pyran-2-carboxylic acid kuita ne tert-butyl formate mushure meesterification kuwana 3-(benzyloxy) -1-((tert-butoxycarbonyl) amino) -4-oxo -1, 4-dihydropyridine-2-methyl formate hydrate, uyezve ne2-(2, 2-dimethoxyethoxy) ethylamine inopinda urethane exchange reaction, uyezve cyclizes pasi pekuita kwemethanesulfonic acid kuti iwane 7-(benzyloxy) -3, 4,12,12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyridino [2,1-f] [1,2,4] triazine -6, 8-dione hemihydrate, zvino ndiyo yakanyungudutswa ne (R) -tetrahydrofuran -2-formic acid, yakazogadziriswa uye yakagadziriswa, uye ipapo boka rekubatsira chiral rinobviswa kuti riwane kiyi chiral parent ring molecule (R) -7- (benzyloxy) -3,4,12, 12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyrido [2,1-f] [1,4] Triazine-6, 8-dione.Ipapo iyo yakakosha yemubereki mhete molecule inoshandiswa kuchinjanisa nen-hexanol pasi pechiito cheGrignard reagent, uyezve nekiyi thiazepine chimedu 7,8-difluoro-6, 11-dihydrodibenzo [B, e] thiazepine -11-doro docking. , uye pakupedzisira debutylation uye condensation nemethyl chloroformate kuti uwane yekupedzisira chigadzirwa Baloxavir Marboxil.