Betamethasone CAS 378-44-9 Purity 97.0%~103.0% API Factory High Purity

Tsanangudzo Pfupi

Kemikari Zita: Betamethasone

CAS: 378-44-9

Kuonekwa: Ichena kana Inenge Yakachena Crystalline Powder

Kuchena: 97.0% ~ 103.0% yeC22H29FO5, pane yakaomeswa

API High Quality, Commercial Production

Bata: Dr. Alvin Huang

Nharembozha/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Tumira email kwatiri

Product Detail

Product Tags

378-44-9 - Tsanangudzo:

Commercial Supply Betamethasone ine High Purity uye Yakagadzikana Hunhu
Kemikari Zita: Betamethasone
CAS: 378-44-9

378-44-9 -Chemical Properties:

Chemical Name	Betamethasone
Mashoko anoreva zvakafanana	Betamethasone Base;9alpha-Fluoro-16beta-Methylprednisolone;9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione;(11beta,16alpha)-9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
Nhamba yeCAS	378-44-9
Stock Status	MuStock, Kugadzirwa Kunokwira Kusvika Matani
Molecular Formula	C22H29FO5
Molecular Weight	392.47
Melting Point	235.0~237.0℃
Shipping Condition	Under Ambient Temperature
COA & MSDS	Available
Brand	Ruifu Chemical

378-44-9 -Zvinotsanangurwa:

Item	Zvinotsanangurwa
Chitarisiko	Ichena kana Inenge Yakachena Crystalline Powder
Identification A	Infrared Absorption
Kuzivikanwa B	Thin-Layer Chromatographic Identification Test
Specific Optical Rotation	+118.0 ° kusvika +126.0 ° (Yakaverengerwa paDried Basis)
Kusachena Kwemunhu	≤1.00%
Zvose Zvisina Kuchena	≤2.00%
Residual Solvents Methanol	≤3000ppm
Residual Solvents Chloroform	≤60ppm
Kurasika paKuomesa	≤0.50% (Iomese pa105 ℃, maawa matatu)
Residue paIgnition	≤0.20%
Kuchena / Analysis Method	97.0% ~ 103.0% yeC22H29FO5 Yakaverengerwa pane Yakaomeswa Basis
Test Standard	Chinese Pharmacopoeia (CP);EP10.0 uye USP 42
Packaging uye Kuchengeta	Chengetedza mumidziyo yakaoma.Chengetedza pakati pe2℃ ne30℃.
Application	Active Pharmaceutical Ingredient (API)

Package & Kuchengeta:

Package:Bhodhoro, Aluminium foil bag, 25kg/Cardboard Drum, kana zvinoenderana nezvinodiwa nemutengi.
Storage Condition:Chengetedza mudziyo wakavharwa zvakasimba uye chengeta munzvimbo inotonhorera, yakaoma (2~30 ℃) uye ine mhepo yakanaka yekuchengetera zvinhu kure nezvinhu zvisingaenderane.Gara kure nechiedza chakasimba uye kupisa, unyoro.
KutumiraKuendesa kupasirese nemhepo, neFedEx / DHL Express.Ipa kutumirwa nekukurumidza uye kwakavimbika.

Zvakanakira:

FAQ:

378-44-9 - Njodzi uye Kuchengeteka:

Risk Codes R40 - Humbowo hushoma hwekuita carcinogenic
R48/20/21 -
R61 - Inogona kukonzera kukuvadza kumwana asati aberekwa
Tsanangudzo Yekuchengetedza S22 - Usafeme guruva.
S36 - Pfeka zvipfeko zvinodzivirira zvakakodzera.
S45 - Kana pakaitika tsaona kana ukanzwa usinganzwe zvakanaka, tsvaga zano rekurapa nekukasira (ratidza chinyorwa pese pazvinogoneka.)
S53 - Dzivisa kuratidzwa - wana mirairo yakakosha usati washandisa.
WGK Germany 2
RTECS TU4000000
HS Code 2937229000
Toxicity LD50 oral in mouse:> 4500mg/kg

378-44-9 -Application:

Betamethasone (CAS: 378-44-9), ndeye adrenal corticosteroids, iri isomer ye dexamethasone, uye basa re betamethasone rakafanana ne prednisolone uye dexamethasone, ine anti-inflammatory, anti-rheumatic, anti-allergic uye kudzvinyirira. yezvidziviriro zvekudzivirira uye mamwe maitiro emishonga, maitiro ayo anopesana nekuputika ane simba kupfuura dexamethasone, triamcinolone, hydrocortisone nezvimwewo, inogona kuderedza uye kudzivirira mhinduro yetishu pakupisa uye kubvisa kupisa, kutsvuka uye kuputika kunokonzerwa nehutachiona hwemunharaunda husina hutachiona, nokudaro kuderedza. kushanda kwekuzvimba, anti-inflammatory effect yechigadzirwa ichi 0.3mg yakaenzana nedexamethasone 0.75mg, prednisone 5mg kana 25mg cortisone.Betamethasone sodium retention effect yakapetwa kazana kupfuura hydrocortisone, muprimary adrenal hypofunction, inogona kushandiswa pamwe chete neglucocorticoid yekutsiva kurapa, uye inoshandiswa kudzivirira kana kuvharira ma cell-mediated immune reaction, kunonoka kupindirana kwemuviri uye kuderedza yekutanga immune system. mhinduro yekuwedzera, inoshandiswa kune yakaderera renin uye yakaderera aldosterone syndrome uye autonomic neuropathy inokonzerwa orthostatic hypotension.Parizvino betamethasone inoshandiswawo kurapa inoshanda rheumatoid arthritis, rheumatoid arthritis, lupus, yakanyanya bronchial asthma, yakanyanya dermatitis, acute leukemia, atopic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, uye pruritus uye kurapa kwakakwana kwezvimwe zvirwere.Chigadzirwa chacho chinopesana munhoroondo yakaoma yepfungwa, inoshanda duodenal ulcer, ichangoburwa gastrointestinal anastomosis, inorema osteoporosis, overt diabetes, yakanyanya hypertension, utachiona , bhakitiriya, zvirwere zvefungal izvo zvinokundikana kudzora nekushandisa antimicrobial agents , thrombophlebitis, zvirwere zveganda, zvakadai. se impetigo, tinea, jock itch uye zvichingodaro.

378-44-9 - USP35 Standard:

Betamethasone
C22 H29FO5 392.46
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11,16)-.
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione [378-44-9].
Betamethasone ine kwete pasi pe97.0 muzana uye kwete kupfuura 103.0 muzana yeC22H29FO5, yakaverengerwa pane yakaomeswa.
Kurongedza uye kuchengetedza-Chengetedza mumidziyo yakaoma.Chengetedza pakati pe2℃ ne30℃.
USP Reference mwero <11>-
USP Betamethasone RS
Identification-
A: Infrared Absorption <197M>.
B: Thin-Layer Chromatographic Identification Test <201>-
Muedzo mhinduro-Gadzirira mhinduro yeBetamethasone mudoro risina mvura rine 0.5 mg per mL.
Kugadzira solvent system: musanganiswa wechloroform uye diethylamine (2: 1).
Maitiro-Rambai sekurairwa muchitsauko, kunze kwekutsvaga makwapa nekupfapfaidza zvishoma ne dilute sulfuric acid (1 mu2) nekudziya pandiro inopisa kana pasi perambi kusvika makwapa aoneka.
Kutenderera kwakananga <781S>: pakati pe +118 uye +126, yakaverengerwa pane yakaomeswa.
Mhinduro yekuedza: 5 mg pa mL, mu methanol.
Kurasikirwa pakuomesa 731-Dry it pa105 kwemaawa matatu: inorasikirwa kwete kupfuura 1.0% yehuremu hwayo.
Zvisaririra pamoto 281: kwete kupfuura 0.2%, platinamu crucible iri kushandiswa.
Kusachena kwakajairika 466-
Muedzo mhinduro: methanol.
Standard mhinduro: methanol.
vhoriyamu yekushandisa: 10 µL.
Eluant: musanganiswa we toluene, acetone, methyl ethyl ketone, uye formic acid (55:20:20:5), mukamuri isina kukwana.
Kuona: 5.
Kuongorora-
Nharembozha-Gadzirira musanganiswa wakanatswa uye wakasvibiswa wemvura uye acetonitrile (63:37).Ita zvigadziriso kana zvichidikanwa (ona System Suitability pasi peChromatography 621).
Yemukati chiyero mhinduro-Gadzirira mhinduro yepropylparaben mudoro ine huwandu hunozivikanwa hunosvika 0.25 mg per mL.
Kugadzirira kwakajairwa-Dyisa huwandu hwakayerwa nemazvo hweUSP Betamethasone RS mudoro kuti uwane mhinduro ine huwandu hunozivikanwa hunosvika 0.2 mg pamL.Shandura 10.0 mL yemhinduro iyi kubhodhoro rakakodzera, uye wedzera 10.0 mL yeInternal standard solution, kuti uwane gadziriro yeStandard ine zvinozivikanwa zvakadzika zvingangoita 0.1 mg yebetamethasone uye inenge 0.125 mg yepropylparaben per mL.
Kugadzirira kweAssay-Kushandisa inenge 80 mg yeBetamethasone, yakanyatsoyerwa, gadzirira sezvakarayirwa nokuda kwekugadzirira Standard.
Chromatographic system (ona Chromatography 621) -Iyo chromatograph yemvura ine 240-nm detector uye 4.6-mm × 25-cm column ine kurongedza L1.Chiyero chekuyerera chinenge 1.0 mL paminiti.Chromatograph the Standard gadziriro, uye rekodha mhinduro dzepamusoro sekurairwa kwaProcedure: nguva dzekuchengeta dzinenge 1.0 yebetamethasone uye 1.4 yepropylparaben;chisarudzo, R, pakati pebetamethasone nepropylparaben haisi pasi pe3.0;uye kutsauswa kwakayerwa kwemajekiseni ekudzokorora hakupfuuri 2.0%.
Maitiro-Kuparura jekiseni mavhoriyamu akaenzana (angangoita 10 µL) eGwaro gadziriro uye gadziriro yeAssay muchromatograph, rekodha machromatogram, uye kuyera mhinduro dzepamusoro-soro.Verenga huwandu, mu mg, hweC22H29FO5 muchikamu cheBetamethasone chakatorwa neformula:
800C(RU / RS)
umo C ndiyo yekuisa, mu mg per mL, yeUSP Betamethasone RS muStandard gadziriro;uye RU neRS ndiwo mareshiyo ehurefu hwepamusoro pebetamethasone peak uye yemukati mwero peak inowanikwa kubva muAssay gadziriro uye Standard gadziriro, zvichiteerana.